Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis

Microfluidic technology provides a portable, cost-effective, and versatile tool for point-of-care (POC) bioanalysis because of its associated advantages such as fast analysis, low volumes of reagent con-sumption, and high portability. Along with microfluidics, the application of nanomaterials in biosensing has attracted lots of attention due to their unique physical and chemical properties for enhanced signal modulation such as signal amplification and signal transduction for POC bioanalysis. Hence, an enormous number of microfluidic devices integrated with nano-sensors have been developed for POC bioanalysis targeting low-resource settings. Herein, we review recent advances in POC bioanalysis on nano-sensor -based microfluidic platforms. We first briefly summarized the different types of cost-effective micro-fluidic platforms, followed by a concise introduction to nanomaterial-based biosensors. Then, we high-lighted the application of microfluidic platforms integrated with nano-sensors for POC bioanalysis. Finally, we discussed the current limitations and perspective trends of the nano-sensor-based micro-fluidic platforms for POC bioanalysis.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

This article reviews the recent advances in point-of-care (POC) bioanalysis using nano-sensor-based microfluidic platforms. It covers the different types of cost-effective microfluidic platforms, nanomaterial-based biosensors, and the application of microfluidic platforms integrated with nano-sensors in POC bioanalysis. The current limitations and future trends of nano-sensor-based microfluidic platforms for POC bioanalysis are also discussed.