Article
Engineering, Chemical
Ran An, Shengxin Chen, Shun Hou, Yuting Zhu, Chunhu Li, Xinbao Zhu, Ruixia Liu, Weizhong An
Summary: A double-effect reactive distillation (DERD) process is proposed to improve the selectivity and energy utilization in the production of propylene glycol methyl ether. The DERD process achieves over 95% selectivity and significant energy savings by utilizing the overhead vapor steam. The DERD process shows a lower cost compared to the traditional single-column reactive distillation process.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2022)
Article
Engineering, Chemical
Changfang Yin, Guilian Liu
Summary: Integrating the reaction and extractive distillation system can reduce process costs. A systematic method is proposed to determine the optimal conditions, including solvent, solvent-to-feed ratio, extractive distillation sequence, and reactor operating conditions. This method can be used to evaluate different conditions for achieving the minimum total annualized cost.
Article
Engineering, Chemical
Thomas Brouwer, Boelo Schuur
Summary: In this study, DL-limonene was identified as the only biobased solvent capable of breaking the azeotrope in the separation of acetone and diisopropyl ether using extractive distillation. The experimental data was successfully correlated with NRTL and UNIQUAC models, showing that DL-limonene exhibited selective repulsion towards acetone, leading to higher acetone relative volatility compared to other solvents. The observations are in line with literature findings on the preference of oxygenated polar solvents towards ketones and apolar solvents inducing higher volatility of ketones.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Chemical
Aejin Lee, Yus Donald Chaniago, Juli Ayu Ningtyas, Hosanna Uwitonze, Hankwon Lim
Summary: This study uses optimal extractive distillation and extractive dividing wall column to recover waste solvent, and multi-objective optimization using genetic algorithm is conducted by linking Aspen Plus and MATLAB. The optimized cases are compared in terms of energy, economic, and environmental parameters, and it is found that the extractive dividing wall column can achieve potential energy savings of 26.29%, total annual cost savings of 24.15%, and an exergy efficiency of 21.02%. Optimization can significantly reduce exergy losses associated with the number of trays, while dividing wall column can significantly reduce exergy losses associated with remixing. Further, multi-objective optimization using a genetic algorithm and a range of populations provides various results for process selection.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Materials Science, Paper & Wood
Yusuke Matsumoto, Tomohiro Yamada, Thi Thi Nge, Tatsuhiko Yamada
Summary: In this study, glycol lignins (GLs) were synthesized via acid-catalyzed solvolysis of softwood meal using monomethyl ethers of polyethylene glycol (MPEG). The yield, molecular weight, and thermal properties of MPEG-lignin were studied under different reaction times and temperatures. The results showed that the yield of MPEG-lignin increased with solvolysis time, and acid-catalyzed solvolysis using MPEG-n4 occurred faster than that using MPEG-n8. Higher reaction temperature resulted in a higher yield of MPEG-lignin with increased glass transition temperature (T9) and viscous thermal flow temperature (Ti).
Article
Energy & Fuels
Yus Donald Chaniago, Le Cao Nhien, Ahmad Naquash, Amjad Riaz, Gwang Sik Kim, Hankwon Lim, Moonyong Lee
Summary: A novel heat integrated and intensified design using dividing wall column, reactive distillation, and pressure swing techniques was proposed for improving the energy efficiency and reducing the cost of PGMEA production. Heat integration was applied to maximize the heat recovery of the process, leading to a significant reduction in energy requirement and total annual cost compared to the conventional process.
Article
Engineering, Chemical
Jianguang Qi, Yajuan Qu, Mengjin Zhou, Zihao Su, Xiaoying Zhang, Ranran Wei, Ke Xue, Zhaoyou Zhu, Fanqing Meng, Yinglong Wang
Summary: This study prepared deep eutectic solvents (DESs) based on choline chloride (ChCl) and tetrabutylammonium bromide (TBAB) as hydrogen bond acceptors (HBAs) and urea, glycerol (G), malonic acid (MA), and levulinic acid (LA) as hydrogen bond donors (HBDs). The experimental and quantum chemical (QC) results showed that DESs have a significant effect on the intermolecular forces and can effectively separate the binary azeotropes of methanol (MeOH) and dimethyl carbonate (DMC).
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Toxicology
K. Z. Isoardi, C. B. Page, M. S. Roberts, G. K. Isbister
Summary: Triclopyr, a herbicide with low toxicity, can cause life-threatening toxicity when ingested in formulations containing diethylene glycol monoethyl ether (DEGEE), leading to high anion gap metabolic acidosis. Management should focus on supportive care, including dialysis.
CLINICAL TOXICOLOGY
(2021)
Article
Thermodynamics
Rasoul Hassanalizadeh, Wayne Michael Nelson, Bradlee Kevin Naidoo, Mojgan Ebrahiminejadhasanabadi, Paramespri Naidoo, Deresh Ramjugernath
Summary: The study investigated the separation of nitrogen trifluoride and tetrafluoromethane using a specific entrainer, and measured isothermal phase equilibrium data to show the affinity of the solvent for nitrogen trifluoride.
FLUID PHASE EQUILIBRIA
(2022)
Article
Thermodynamics
Cong Duan, Chunli Li
Summary: Three-column extractive distillation is commonly used for separating dilute azeotropic components. In this study, new findings regarding heat integration in this process are presented. It is discovered for the first time that the composition of the pre-concentrator distillate and the solvent feed temperature have unexpected effects on heat integration. Various forms of heat integration can be fully thermally integrated by adjusting parameters, including the two mentioned above. Splitting the fresh feed into two streams for the pre-concentrator and the extractive column can also improve heat-integrated processes. Based on these findings, four improvement methods are proposed and their feasibility is demonstrated through case studies.
Article
Green & Sustainable Science & Technology
Haiyang Cheng, Jianhui Zhong, Yasen Dai, Yuyang Jiao, Zhaoyou Zhu, Peizhe Cui, Jianguang Qi, Yinglong Wang
Summary: This study developed a highly efficient separation of ethyl acetate/ethanol/water azeotrope using extractive distillation with a mixed solvent. The optimal process scheme was obtained through multi-objective optimization, considering both economy and environment. The results showed that the heat pump-assisted extractive distillation process had significant advantages in terms of gas emission reduction and energy consumption. This study is of great significance for the separation of high purity ethyl acetate and the recovery of wastewater.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Chemistry, Physical
Homa Rezaei, Elaheh Rahimpour, Hongkun Zhao, Fleming Martinez, Abolghasem Jouyban
Summary: The thermodynamics and solubilization behavior of caffeine in a non-aqueous binary mixture of NMP and PG at varying temperatures were studied. Different cosolvency models were used to represent the solubility data and their accuracy was evaluated. Apparent thermodynamic parameters for the caffeine dissolution process in the binary mixture were computed and discussed.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Xiangui Wang, Huajie Xu, Yanming Zou, Wei Hu, Lu Wang
Summary: In this study, a technical scheme for the separation of benzene and cyclohexane using deep eutectic solvents (DESs) as an entrainer in extractive distillation was proposed. Experimental results showed that DESs significantly improved the separation efficiency of the system. Quantitative calculations and molecular dynamics simulations revealed the separation mechanism and demonstrated that the interaction between DESs and benzene was stronger than that with cyclohexane. Therefore, DESs as an entrainer for azeotrope separation have broad industrial application prospects.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemical Research Methods
Lakshmi Narasimha Rao Katakam, Santhosh Kumar Ettaboina, Vishnu Murthy Marisetti
Summary: A simple and isocratic reverse-phase liquid chromatography with mass spectrometric method has been developed and validated for the determination of heptaethylene glycol monomethyl ether in benzonatate drug substance, which may improve the quality and purity of the drug substance.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Engineering, Chemical
Yao Wang, Qing Ye, Jinlong Li, Qingqing Rui, Azhi Yu
Summary: This study compares the performance of extractive distillation (ED), solvent-assisted pressure-swing distillation (SA-PSD), and SA-PSD with partial heat integration (PHI-PSD) processes for the separation of a cyclohexane/2-butanol mixture. The results show that the ED process with NMP as entrainer has the best economic and thermodynamic efficiency.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2023)
Review
Thermodynamics
Muhammad Abdul Qyyum, Ahmad Naquash, Junaid Haider, Saad A. Al-Sobhi, Moonyong Lee
Summary: This article discusses the current evaluation and future development direction of NGLs recovery processes, highlighting the higher SEC and lower operating costs of low NGL component feeds, as well as the higher energy intensity and complexity of conceptual processes compared to commercial processes.
Article
Thermodynamics
Ahmad Naquash, Muhammad Abdul Qyyum, Muhammad Islam, Noman Raza Sial, Seongwoong Min, Sanggyu Lee, Moonyong Lee
Summary: This study focuses on the design and analysis of an integrated liquid hydrogen production process. By integrating an absorption refrigeration system, liquid air energy storage system, and organic Rankine cycle, the process aims to achieve energy efficiency and waste heat recovery. The results show that the liquefaction section is the most energy-intensive part, and multi-stream heat exchangers contribute significantly to exergy destruction. Economic analysis reveals that compressors and multi-stream heat exchangers are the major capital investments.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Review
Thermodynamics
Muhammad Abdul Qyyum, Amjad Khan, Sajid Ali, Muhammad Shahzad Khurram, Ning Mao, Ahmad Naquash, Adnan Aslam Noon, Tianbiao He, Moonyong Lee
Summary: This paper presents a state-of-the-art review on organic Rankine cycle (ORC) technology, examining the working fluids, thermal resources, cooling utilities, and commercial status. The study finds that mixed working fluids achieve higher thermodynamic efficiency, but their application is limited by difficulties in determining the optimal composition and components. Low-temperature ORC systems utilizing waste heat and geothermal energy are prevalent, while biomass and solar energy are underutilized as heat resources for ORC. The United States and Europe are leading in commercial applications of ORC for converting low-grade waste heat into useful power. The main challenges for ORC are selecting suitable working fluids and expanders, as well as reducing the specific cost of small-scale ORC systems to compete with renewable energy. Future research directions include investigating the overall performance, stability, and safety of ORC systems, developing a general methodology for selecting working fluids, and conducting techno-economic optimization studies to reduce costs. This study provides an overview of the recent progress in ORC technology and highlights the scientific problems that need to be addressed to harness low-grade heat for power generation in the future.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Article
Thermodynamics
Ahmad Naquash, Muhammad Abdul Qyyum, Seongwoong Min, Sanggyu Lee, Moonyong Lee
Summary: Hydrogen is an important clean energy carrier, but its storage and transportation face challenges. This study proposes an energy-efficient and cost-effective process for producing liquid hydrogen to enhance its energy density, using stepwise cooling and ortho-para conversion.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Article
Thermodynamics
Hosanna Uwitonze, Yus Donald Chaniago, Hankwon Lim
Summary: This study proposes an integrated process for offshore natural gas liquefaction and NGLs recovery based on single mixed refrigerant (SMR) cycle. The process features compact integration and a flexible NGLs recovery section.
Article
Green & Sustainable Science & Technology
Amjad Riaz, Yus Donald Chaniago, Arif Hussain, Riezqa Andika, Gwangsik Kim, Hankwon Lim, Moonyong Lee
Summary: The utilization of carbon dioxide to create valuable products such as methanol has the potential to address carbon emissions and global warming, while also providing a solution for the intermittency and security of renewable energy supply. This concept showcases the tremendous potential of zero-carbon-emission methanol production.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Energy & Fuels
Ashfaq Ahmad, Kinza Qadeer, Ahmad Naquash, Fahid Riaz, Mudassir Hasan, Muhammad Abdul Qyyum, Moonyong Lee
Summary: This study investigates the feasibility of liquefied natural gas (LNG) process under variable natural gas (NG) conditions using an artificial intelligence approach. A particle swarm optimization-artificial neural network (PSO-ANN) model is developed to predict the decision variables of the LNG process. The model shows a success rate of 80% and can handle a diverse range of temperature and pressure values.
FRONTIERS IN ENERGY RESEARCH
(2022)
Article
Environmental Sciences
Ahmad Naquash, Muhammad Nizami, Muhammad Abdul Qyyum, Rashid S. Al-Hajri, Moonyong Lee
Summary: Communication gaps between academic researchers and industry practitioners hinder the large-scale application of membrane-based natural gas liquid (NGL) recovery processes. A comprehensive process systems engineering (PSE) assessment is necessary to determine the commercial suitability of these processes. This review presents the technical and economic aspects of standalone and integrated membrane processes and identifies the key challenges and issues faced by membrane processes.
Article
Environmental Sciences
Ahmad Naquash, Muhammad Abdul Qyyum, Yus Donald Chaniago, Amjad Riaz, Fatma Yehia, Hankwon Lim, Moonyong Lee
Summary: This study evaluated membrane-assisted (case-I) and cryogenic-assisted (case-II) hydrogen (H2) separation and purification technologies in terms of energy, exergy, and economic aspects. The results showed that case-I had lower energy consumption, higher exergy efficiency, but higher cost than case-II. This study can assist industry practitioners and academic researchers in selecting optimal H2 separation and purification technologies.
Article
Thermodynamics
Muhammad Abdul Qyyum, Ahmad Naquash, Noman Raza Sial, Moonyong Lee
Summary: Small-scale LNG processes face challenges of low energy efficiency and high process costs. A dual-phase expander-based process assisted by CO2 precooling has been proposed to improve these issues. Among the proposed cases, using CO2 precooling and C2/N2 liquefaction is the most energy-efficient and cost-effective option.
Article
Thermodynamics
Amjad Riaz, Muhammad Abdul Qyyum, Ahmad Naquash, Moonyong Lee
Summary: Liquid air energy storage (LAES) system shows promise as a solution to the intermittent nature and dependency on weather/climate of renewable energy. This study proposes a self-recuperative process using stored liquid air as a refrigerant, resulting in a round-trip efficiency of 75.8%. The process consumes 58% less power compared to the base case, opening up possibilities for further integration and continuous power generation in remote/off-grid locations.
APPLIED THERMAL ENGINEERING
(2023)
Article
Engineering, Chemical
Aejin Lee, Yus Donald Chaniago, Juli Ayu Ningtyas, Hosanna Uwitonze, Hankwon Lim
Summary: This study uses optimal extractive distillation and extractive dividing wall column to recover waste solvent, and multi-objective optimization using genetic algorithm is conducted by linking Aspen Plus and MATLAB. The optimized cases are compared in terms of energy, economic, and environmental parameters, and it is found that the extractive dividing wall column can achieve potential energy savings of 26.29%, total annual cost savings of 24.15%, and an exergy efficiency of 21.02%. Optimization can significantly reduce exergy losses associated with the number of trays, while dividing wall column can significantly reduce exergy losses associated with remixing. Further, multi-objective optimization using a genetic algorithm and a range of populations provides various results for process selection.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Ayeon Kim, Heehyang Kim, Yus Donald Chaniago, Hankwon Lim
Summary: The capture of carbon dioxide from ocean water and utilizing it for methane production can reduce carbon emissions, but a comprehensive analysis is needed to determine the potential. Through techno-economic and carbon dioxide emission analyses, different options for extraction, location, electricity sources, and transport media were considered. The results showed that the unit methane supply costs ranged from $3.5 to $7.5 per kgCH4, with the majority of the cost attributed to hydrogen electrolysis. The emission analysis revealed that while carbon utilization resulted in negative emissions, the use of synthesized methane in power plants led to positive emissions. To achieve carbon neutrality, capture rates of 54.44% and 77.62% were suggested for different pathways. The reduction in cost, especially the levelized cost of electricity, is crucial for the pathways to be economically competitive.
SUSTAINABLE PRODUCTION AND CONSUMPTION
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
