Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites

The bacterial toxin colibactin triggers prophage induction

(2022) Justin E. Silpe et al.   NATURE

A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling

(2022) Jiandong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial production of multiple short-chain primary amines via retrobiosynthesis

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Molecules from the Microbiome

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Shining a Light on Colibactin Biology

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Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations

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Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study

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Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

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Colorectal cancer in Crohn's disease: a Scandinavian population-based cohort study

(2020) Ola Olén et al.   Lancet Gastroenterology & Hepatology

Microbiome analyses of blood and tissues suggest cancer diagnostic approach

(2020) Gregory D. Poore et al.   NATURE

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer

(2020) Paulina J. Dziubańska-Kusibab et al.   NATURE MEDICINE

Somatic Evolution in Non-neoplastic IBD-Affected Colon

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The Genotoxin Colibactin Shapes Gut Microbiota in Mice

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Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development

(2019) Jawara Allen et al.   Genome Medicine

The human gut bacterial genotoxin colibactin alkylates DNA

(2019) Matthew R. Wilson et al.   SCIENCE

Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities

(2019) Katrin Unterhauser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

(2019) Haiwei Chen et al.   CELL

An Essential Regulator of Bacterial Division Links FtsZ to Cell Wall Synthase Activation

(2019) Patrick J. Lariviere et al.   CURRENT BIOLOGY

The Integrative Human Microbiome Project

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Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

(2019) Andrew Maltez Thomas et al.   NATURE MEDICINE

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

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Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

(2019) NaNa Keum et al.   Nature Reviews Gastroenterology & Hepatology

Structure elucidation of colibactin and its DNA cross-links

(2019) Mengzhao Xue et al.   SCIENCE

Increased Epithelial Oxygenation Links Colitis to an Expansion of Tumorigenic Bacteria

(2019) Stephanie A. Cevallos et al.   mBio

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

The Intestinal Microbiota in Colorectal Cancer

(2018) Herbert Tilg et al.   CANCER CELL

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

(2018) Christine M. Dejea et al.   SCIENCE

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

(2018) Nadège Bossuet-Greif et al.   mBio

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

(2018) Emilee E. Shine et al.   ACS Chemical Biology

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis

(2017) Eric P. Trautman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

(2017) Dylan Dodd et al.   NATURE

Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring

(2017) Li Zha et al.   Nature Chemical Biology

Rapid curation of gene disruption collections using Knockout Sudoku

(2017) Isao A Anzai et al.   Nature Protocols

Gut Microbiota, Inflammation, and Colorectal Cancer

(2016) Caitlin A. Brennan et al.   Annual Review of Microbiology

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications

(2016) John Freedman et al.   Toxins

Illuminating the dark matter in metabolomics: Fig. 1.

(2015) Ricardo R. da Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer and the microbiota

(2015) W. S. Garrett   SCIENCE

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RASTtk: A modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes

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Trimmomatic: a flexible trimmer for Illumina sequence data

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Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

(2014) Antony Cougnoux et al.   GUT

The Genotoxin Colibactin Exacerbates Lymphopenia and Decreases Survival Rate in Mice Infected With Septicemic Escherichia coli

(2014) I. Marcq et al.   JOURNAL OF INFECTIOUS DISEASES

Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis

(2014) G. Schneditz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

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Assembling Single-Cell Genomes and Mini-Metagenomes From Chimeric MDA Products

(2013) Sergey Nurk et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

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XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data

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Transposon mutagenesis of the anaerobic commensal, Bacteroides fragilis, using the EZ::TN5 transposome

(2012) Yaligara Veeranagouda et al.   FEMS MICROBIOLOGY LETTERS

Epidermal growth factor receptor inhibits colitis-associated cancer in mice

(2012) Philip E. Dubé et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer

(2012) Weiguang Chen et al.   PLoS One

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

(2012) J. C. Arthur et al.   SCIENCE

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

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Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

(2009) Kent S. Gates   CHEMICAL RESEARCH IN TOXICOLOGY

Genetic Structure and Distribution of the Colibactin Genomic Island among Members of the Family Enterobacteriaceae

(2009) J. Putze et al.   INFECTION AND IMMUNITY