期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 43, 期 6, 页码 1500-1506出版社
WILEY
DOI: 10.1002/jmri.25127
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资金
- Taipei Tzu-Chi General Hospital [TCRD-TPE-103-04, TCRD-TPE-104-01]
- Cheng Hsin General Hospital
- National Yang Ming University [104F003C03]
Purpose: To assess the existence of alterations in the micro-integrity of the fasciculus in prediabetic subjects. The issue of micro-integrity in white matter tracts has not been adequately addressed in prediabetes. Materials and Methods: Sixty-four prediabetic subjects and 54 controls were enrolled. All participants completed 24-hour diet records and 3-day diet records and received diffusion tensor imaging at 3T. The data for white matter micro-integrity were analyzed and compared between prediabetic subjects and controls with age and gender as covariates. In addition, voxel-wise regression between white matter micro-integrity, diet, and preprandial glucose levels were used to explore the relationship between white matter micro-integrity and diet or serum glucose levels. Results: We found that prediabetic subjects had significant reductions in the micro-integrity of bilateral anterior thalamic radiation, left inferior longitudinal fasciculus, and left superior longitudinal fasciculus (corrected P < 0.05). In addition, total carbohydrate intake amount and preprandial serum glucose levels were negatively correlated with the micro-integrity in the left inferior longitudinal fasciculus and left anterior thalamic radiation (r: -0.47, corrected P < 0.05). Conclusion: Restrictive alterations in the white matter micro-integrity of the anterior thalamic radiation and inferior and superior longitudinal fasciculi might represent the initial hot spots for white matter tract alterations, which might play a role in the development of prediabetes.
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