期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 44, 期 6, 页码 1650-1655出版社
WILEY
DOI: 10.1002/jmri.25294
关键词
fetal MRI; diffusion MRI; motion artifacts; fetal lung; ADC; gestational age
资金
- NIH [R01 EB019483, R01 EB013248, R01 EB018988, R01 NS079788, R42 MH086984]
PurposeTo evaluate the feasibility of using diffusion-weighted magnetic resonance imaging (DW-MRI) to assess the fetal lung apparent diffusion coefficient (ADC) at 3 Tesla (T). Materials and MethodsSeventy-one pregnant women (32 second trimester, 39 third trimester) were scanned with a twice-refocused Echo-planar diffusion-weighted imaging sequence with 6 different b-values in 3 orthogonal diffusion orientations at 3T. After each scan, a region-of-interest (ROI) mask was drawn to select a region in the fetal lung and an automated robust maximum likelihood estimation algorithm was used to compute the ADC parameter. The amount of motion in each scan was visually rated. ResultsWhen scans with unacceptable levels of motion were eliminated, the lung ADC values showed a strong association with gestational age (P < 0.01), increasing dramatically between 16 and 27 weeks and then achieving a plateau around 27 weeks. ConclusionWe show that to get reliable estimates of ADC values of fetal lungs, a multiple b-value acquisition, where motion is either corrected or considered, can be performed. J. Magn. Reson. Imaging 2016;44:1650-1655.
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