Article
Critical Care Medicine
John C. Greenwood, David H. Jang, Audrey E. Spelde, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Benjamin S. Abella
Summary: This study found that low perfused vessel density and high microcirculatory heterogeneity are associated with an increased intensity and duration of lactic acidosis after cardiac surgery with cardiopulmonary bypass.
Article
Multidisciplinary Sciences
John C. Greenwood, Fatima M. Talebi, David H. Jang, Audrey E. Spelde, Joseph E. Tonna, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Jacob S. Brenner, Vladimir R. Muzykantov, Benjamin S. Abella
Summary: This study evaluated the microcirculatory function in patients with circulatory shock after cardiac surgery using a low-dose topical nitroglycerin solution and handheld videomicroscopy. The results showed that patients with shock had persistent and irreversible abnormalities in microcirculatory function, and a topical nitroglycerin challenge was able to assess the localized recruitment of microcirculatory blood flow and identify nitroglycerin responsiveness.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Vincenza Caruso, Guillaume Besch, Maxime Nguyen, Sebastien Pili-Floury, Belaid Bouhemad, Pierre-Gregoire Guinot, Lactel Study Grp
Summary: The study aims to compare the treatment of hyperlactatemia using an algorithm based on the pCO(2) gap and p(v-a)CO2/C(a-v)O-2 ratio with usual clinical practice in acute circulatory failure. The results of this study will provide clinical insights into the early hemodynamic management of acute circulatory failure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maximilian Dietrich, Berkin Oezdemir, Daniel Gruneberg, Clara Petersen, Alexander Studier-Fischer, Maik von der Forst, Felix C. F. Schmitt, Mascha O. Fiedler, Felix Nickel, Beat Peter Mueller-Stich, Thorsten Brenner, Markus A. Weigand, Florian Uhle, Karsten Schmidt
Summary: Hyperspectral imaging (HSI) can detect dynamic changes in tissue oxygenation and perfusion quality during shock, evaluate treatment effectiveness, and assess the correlation between skin and kidney measurements, opening up new opportunities for hemodynamic management.
Article
Anesthesiology
John C. Greenwood, David H. Jang, Stephen D. Hallisey, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Christian A. Bermudez, Victoria L. Zhou, Shampa Chatterjee, Frances S. Shofer, Todd J. Kilbaugh, John G. T. Augoustides, Nuala J. Meyer, Jan Bakker, Benjamin S. Abella
Summary: Resuscitation after cardiac surgery must address multiple pathophysiological processes, including microcirculatory dysfunction which may lead to increased lactate levels and acute organ injury. A study on 25 adults undergoing elective cardiac surgery found that severely impaired perfused vessel density was significantly related to hyperlactatemia and early organ injury.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Biochemistry & Molecular Biology
Robert T. Mankowski, Stephanie E. Wohlgemuth, Guilherme Bresciani, A. Daniel Martin, George Arnaoutakis, Tomas Martin, Eric Jeng, Leonardo Ferreira, Tiago Machuca, Mindaugas Rackauskas, Ashley J. Smuder, Thomas Beaver, Christiaan Leeuwenburgh, Barbara K. Smith
Summary: Mechanical ventilation during cardiothoracic surgery can lead to ventilator-induced diaphragm dysfunction (VIDD) and delay recovery. In this study, intraoperative phrenic nerve stimulation was performed to offset VIDD and investigate changes in mitochondrial function.
Article
Peripheral Vascular Disease
John C. Greenwood, Fatima M. Talebi, David H. Jang, Audrey E. Spelde, Emily K. Gordon, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Jacob S. Brenner, Vladimir R. Muzykantov, Benjamin S. Abella
Summary: Microcirculatory dysfunction after cardiovascular surgery is associated with significant morbidity and worse clinical outcomes. Changes in plasma soluble endothelial cell adhesion molecules (VCAM-1, ICAM-1, and E-Selectin) may be useful biomarkers for identifying abnormal microcirculatory blood flow in patients with shock.
MICROVASCULAR RESEARCH
(2023)
Article
Critical Care Medicine
Wagner Luis Nedel, Nathan Ryzewski Strogulski, Afonso Kopczynski, Marcelo Salimen Rodolphi, Thiago Hermes Maeso Montes, Jose Abruzzi Junior, Gilberto Friedman, Luis Valmor Portela
Summary: In septic shock, changes in lymphocytic mitochondrial metabolism are associated with post-resuscitation arterial lactate, but not with the presence of a hypoperfusional status.
Article
Critical Care Medicine
Thomas W. L. Scheeren, Jan Bakker, Thomas Kaufmann, Djillali Annane, Pierre Asfar, E. Christiaan Boerma, Maurizio Cecconi, Michelle S. Chew, Bernard Cholley, Maria Cronhjort, Daniel De Backer, Arnaldo Dubin, Martin W. Duenser, Jacques Duranteau, Anthony C. Gordon, Ludhmila A. Hajjar, Olfa Hamzaoui, Glenn Hernandez, Vanina Kanoore Edul, Geert Koster, Giovanni Landoni, Marc Leone, Bruno Levy, Claude Martin, Alexandre Mebazaa, Xavier Monnet, Andrea Morelli, Didier Payen, Rupert M. Pearse, Michael R. Pinsky, Peter Radermacher, Daniel A. Reuter, Yasser Sakr, Michael Sander, Bernd Saugel, Mervyn Singer, Pierre Squara, Antoine Vieillard-Baron, Philippe Vignon, Jean-Louis Vincent, Iwan C. C. van der Horst, Simon T. Vistisen, Jean-Louis Teboul
Summary: The international survey revealed heterogeneity in the use of inotropes in critically ill patients with circulatory shock. International experts formulated 11 strong recommendations on the indications, choice, triggers and targets for the use of inotropes. Future studies should focus on consistent indications for inotrope use and implementation into a guideline for circulatory shock with individualized targets and outcomes.
ANNALS OF INTENSIVE CARE
(2021)
Article
Biochemistry & Molecular Biology
Anne Kuebart, Katharina Gross, Jan-Joschua Ripkens, Theresa Tenge, Annika Raupach, Jan Schulz, Richard Truse, Stefan Hof, Carsten Marcus, Christian Vollmer, Inge Bauer, Olaf Picker, Anna Herminghaus
Summary: The study aimed to examine the effects of pravastatin on microcirculation and mitochondrial function in the liver and colon, as well as the role of PPAR-alpha in septic conditions. The results showed that pravastatin improved microcirculation in the colon and liver under septic conditions, independent of PPAR-alpha and without affecting mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Martin Wepler, Jonathan M. Preuss, Cornelia Tilp, Martina Keck, Jochen Blender, Ulrich Wachter, Tamara Merz, Josef Vogt, Sandra Kress, Michael Groeger, Andrea Hoffmann, Marina Fink, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Summary: This study investigates the impact of attenuated glucocorticoid receptor (GR) function in mice and respiratory diseases (such as COPD) exacerbating tissue hypoxia via alveolar hypoxia on hemodynamic stability and organ function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wei Chen, Dandan Zheng, Yanru Chen, Huitong Ruan, Yuhui Zhang, Xiuyuan Chen, Hongxing Shen, Lianfu Deng, Wenguo Cui, Hao Chen
Summary: The study utilized electrospun fibers loaded with Hif-1 pathway activator to improve cellular respiration of BMSCs in diabetic fractures, potentially enhancing cell survival and function by protecting mitochondrial function and reconstructing microcirculation.
Article
Multidisciplinary Sciences
Norani H. Gangaram-Panday, Louwrina H. te Nijenhuis, Ilya Fine, Irwin K. M. Reiss, Willem van Weteringen
Summary: Currently, continuous monitoring of the microcirculation in neonatal field is not yet possible. This study investigated a novel dynamic light scattering (DLS) sensor technology for continuous monitoring of the microcirculation in neonatal population. The study found that changes in relative haemodynamic indices were associated with heart rate decelerations.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Robert C. Ross, Elizabeth C. Heintz, Elizabeth R. M. Zunica, R. Leigh Townsend, Amanda E. Spence, Philip R. Schauer, John P. Kirwan, Christopher L. Axelrod, Vance L. Albaugh
Summary: This study investigated the effects of MBS surgery on intestinal mitochondrial function in mice. The results showed that ileal interposition decreased mitochondrial volume in the proximal intestinal mucosa of mice, while respiration remained unchanged. Further studies are needed to understand the underlying causes of these mitochondrial changes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Robert C. Ross, Elizabeth C. Heintz, Elizabeth R. M. Zunica, R. Leigh Townsend, Amanda E. Spence, Philip R. Schauer, John P. Kirwan, Christopher L. Axelrod, Vance L. Albaugh
Summary: Metabolic/bariatric surgery (MBS) is an effective obesity treatment, but its mechanisms for long-term weight loss are unclear. In this study, a highly sensitive technique was used to evaluate the effects of MBS on intestinal mitochondrial function in mice. The results showed that MBS decreased mitochondrial volume in the proximal intestinal mucosa, indicating a global mucosal response to segment specific nutrition signals in the distal bowel.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Anesthesiology
John C. Greenwood, David H. Jang, Stephen D. Hallisey, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Christian A. Bermudez, Victoria L. Zhou, Shampa Chatterjee, Frances S. Shofer, Todd J. Kilbaugh, John G. T. Augoustides, Nuala J. Meyer, Jan Bakker, Benjamin S. Abella
Summary: Resuscitation after cardiac surgery must address multiple pathophysiological processes, including microcirculatory dysfunction which may lead to increased lactate levels and acute organ injury. A study on 25 adults undergoing elective cardiac surgery found that severely impaired perfused vessel density was significantly related to hyperlactatemia and early organ injury.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Review
Anesthesiology
Michael Ibrahim, Audrey E. Spelde, Jacob T. Gutsche, Marisa Cevasco, Christian A. Bermudez, Nimesh D. Desai, Wilson Y. Szeto, Pavan Atluri, Michael A. Acker, Matthew L. Williams
Summary: Coronary artery bypass grafting is an effective mode of myocardial revascularization that reduces mortality from ischemic heart disease, especially in patients with acute myocardial infarction in cardiogenic shock. However, there are still many questions to be answered, and decisions regarding surgical intervention and perioperative management need to be made with caution.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2021)
Article
Critical Care Medicine
John C. Greenwood, David H. Jang, Audrey E. Spelde, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Benjamin S. Abella
Summary: This study found that low perfused vessel density and high microcirculatory heterogeneity are associated with an increased intensity and duration of lactic acidosis after cardiac surgery with cardiopulmonary bypass.
Article
Cardiac & Cardiovascular Systems
Michael Ibrahim, Audrey E. Spelde, Wilson Y. Szeto, Michael A. Acker, Pavan Atluri, Joshua C. Grimm, Marisa Cevasco, Prasanth Vallabhajosyula, Joseph Bavaria, Nimesh D. Desai, Matthew L. Williams
Summary: This study compares the clinical and echocardiographic recovery after aortic valve replacement in patients with aortic stenosis, aortic regurgitation, or mixed disease. The pattern of left ventricular recovery appears to be early in aortic stenosis and delayed in aortic regurgitation. Baseline clinical factors, rather than echocardiographic status, seem to determine long-term survival.
ANNALS OF THORACIC SURGERY
(2022)
Article
Toxicology
David H. Jang, Sarah Piel, John C. Greenwood, Matthew Kelly, Vanessa M. Mazandi, Abhay Ranganathan, Yuxi Lin, Jonathan Starr, Thomas Hallowell, Frances S. Shofer, Wesley B. Baker, Alec Lafontant, Kristen Andersen, Johannes K. Ehinger, Todd J. Kilbaugh
Summary: This study developed a porcine model of CO poisoning and found that low-dose CO poisoning led to decreased mitochondrial respiration and increased ROS generation in the brain and heart tissues. Additionally, there was an increase in cerebral lactate-to-pyruvate ratio and plasma cytokine concentrations in the CO group. These results suggest that mitochondrial dysfunction plays a crucial role in the pathology of CO poisoning, representing a potential target for therapeutic interventions.
CLINICAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Jonathan E. Sevransky, Richard E. Rothman, David N. Hager, Gordon R. Bernard, Samuel M. Brown, Timothy G. Buchman, Laurence W. Busse, Craig M. Coopersmith, Christine DeWilde, Wesley Ely, Lindsay M. Eyzaguirre, Alpha A. Fowler, David F. Gaieski, Michelle N. Gong, Alex Hall, Jeremiah S. Hinson, Michael H. Hooper, Gabor D. Kelen, Akram Khan, Mark A. Levine, Roger J. Lewis, Chris J. Lindsell, Jessica S. Marlin, Anna McGlothlin, Brooks L. Moore, Katherine L. Nugent, Samuel Nwosu, Carmen C. Polito, Todd W. Rice, Erin P. Ricketts, Caroline C. Rudolph, Fred Sanfilippo, Kert Viele, Greg S. Martin, David W. Wright
Summary: A trial on the effects of a combination treatment of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis did not show a significant increase within 30 days. However, the trial was terminated early and may have been underpowered to detect a clinically important difference.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Engineering, Biomedical
Joseph E. Tonna, Darryl Abrams, Daniel Brodie, John C. Greenwood, Jose Alfonso Rubio Mateo-Sidron, Asad Usman, Eddy Fan
Summary: The use of venovenous extracorporeal membrane oxygenation (VV ECMO) in adults is increasing worldwide. This updated ELSO guideline aims to provide practical guidance to clinicians on patient selection, initiation, cannulation, management, and weaning of VV ECMO for adult respiratory failure.
Review
Cell Biology
David H. Jang, Sarah Piel, John C. Greenwood, Johannes K. Ehinger, Todd J. Kilbaugh
Summary: CO poisoning can lead to serious neurological complications for survivors, with treatment primarily relying on hyperbaric oxygen and newer approaches such as succinate prodrugs showing promise. However, there is a lack of cellular-based therapies in this area, highlighting the need for further research and development to improve treatment efficacy for patients with CO poisoning.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Editorial Material
Anesthesiology
Audrey E. Spelde, Marisa E. Hernandez-Morgan, John G. T. Augoustides
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Toxicology
Alistair T. Lewis, Rodrigo M. Forti, Oladunni Alomaja, Clementina Mesaros, Sarah Piel, John C. Greenwood, Fatima M. Talebi, Constantine D. Mavroudis, Matthew Kelly, Shih-Han Kao, Frances S. Shofer, Johannes K. Ehinger, Todd J. Kilbaugh, Wesley B. Baker, David H. Jang
Summary: This study aims to investigate the effects of CO poisoning on brain mitochondrial physiology using a pig model. Preliminary results suggest possible early changes in brain mitochondrial respiration, CIV redox states, and lactate-to-pyruvate ratio in CO-exposed animals.
JOURNAL OF MEDICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
John C. Greenwood, Fatima M. Talebi, David H. Jang, Audrey E. Spelde, Joseph E. Tonna, Jacob T. Gutsche, Jiri Horak, Michael A. Acker, Todd J. Kilbaugh, Frances S. Shofer, John G. T. Augoustides, Jan Bakker, Jacob S. Brenner, Vladimir R. Muzykantov, Benjamin S. Abella
Summary: This study evaluated the microcirculatory function in patients with circulatory shock after cardiac surgery using a low-dose topical nitroglycerin solution and handheld videomicroscopy. The results showed that patients with shock had persistent and irreversible abnormalities in microcirculatory function, and a topical nitroglycerin challenge was able to assess the localized recruitment of microcirculatory blood flow and identify nitroglycerin responsiveness.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Ali Tabatabai, John C. Greenwood, James H. Lantry, Andrea R. Levine, Nirav G. Shah, William C. Chiu, Nicholas A. Morris, Jonathan H. Chow, Samuel A. Tisherman, Michael T. McCurdy
Summary: MarylandCCProject.com, launched by the University of Maryland in July 2013, offers high-quality interdisciplinary critical care education for critical care trainees globally. A recent survey showed that the website is highly valued by current and former trainees for improving medical knowledge and clinical practice.