期刊
PLACENTA
卷 130, 期 -, 页码 9-11出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2022.10.009
关键词
Fetal neurodevelopment; Maternal age; Serotonin metabolism; Neuro-developmental disorders
资金
- Canadian Institutes of Health Research (CIHR) [FDN 143262]
- Cameron Holcombe Wilson Research Chair in Depression Studies, University of Toronto
- Lunenfeld-Tanenbaum Research Institute
- Department of Obstetrics and Gynecology, Sinai Health System
- Mount Sinai Hospital Foundation
This study found a correlation between maternal age and placental protein expression, which is related to fetal neurodevelopment.
High fetal exposure to serotonin and increasing maternal age both contribute to the risk for neurodevelopmental disorders. While identifying covariates for a study of placental protein expression, we found a significant negative correlation between maternal age and the expression of monoamine oxidase A (MAOA), and a significant positive correlation between maternal age and the expression of the serotonin transporter SERT. MAOA and SERT play key roles in placental serotonin metabolism relevant to fetal neurodevelopment. These preliminary findings suggest that the effect of increasing maternal age on neurodevelopmental risk may be mediated in part by changes in placental protein expression relevant to fetal serotonin metabolism.
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