Review
Pharmacology & Pharmacy
Maoying Wei, Wenxin Ma, Wenhua Zhang, Dan Yin, Yiting Tang, Weiyu Jia, Yijia Jiang, Churan Wang, Yanbing Gong
Summary: The study found that Ophiocordyceps sinensis preparations combined with a low-iodine diet or levothyroxine may decrease thyroid autoantibodies and inflammatory responses in patients with Hashimoto's thyroiditis. Additionally, the combination of Ophiocordyceps sinensis preparations with levothyroxine improved free thyroxine (FT4) levels in patients with hypothyroidism. However, the overall quality of the included studies was low, and the safety of Ophiocordyceps sinensis preparations remains unclear. More high-quality, multicenter, large-sample randomized controlled trials are needed in the future to confirm the efficacy and safety of Ophiocordyceps sinensis preparations.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Jinni Hong, Tingting Fu, Weizhen Liu, Yu Du, Cunyun Min, Datao Lin
Summary: The alteration of gut microbiota in diabetic microvascular complications (DC) was examined in this study. Patients with DC had lower diversity and increased abundance of certain bacteria compared to healthy controls (HC) and patients with only diabetes mellitus (DM).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Meixi Liu, Tianying Chang, Di Zou, ChengJi Cui, Chunyan Liu, Shoulin Zhang, Xing Liao
Summary: This systematic review aims to summarize the therapeutic roles of Ophiocordyceps sinensis as adjuvant treatment for dialysis patients and provide clinical evidence. The review will be conducted according to rigorous methods and evaluate the quality of the included studies. It is expected that robust evidence on the effects of O. sinensis during or after treatment can be obtained, which can inform future research and treatment choices.
Review
Medicine, General & Internal
Qian Zhou, Chuyi Han, Yanmei Wang, Shunlian Fu, Yiding Chen, Qiu Chen
Summary: This study's systematic review and meta-analysis demonstrates that Chinese medicinal formula (CMF) therapy has a significant curative effect on relieving oxidative stress in streptozocin-induced diabetic kidney disease (DKD) rats, and CMF is significantly more effective than Western medicine treatment.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Chaoqun Song, Zhiyue Zhu, Miao Liu, Wenbo Yang, Xiaotian Bai, Zheng Nan
Summary: This study will conduct a systematic review and meta-analysis to evaluate the indicators of Xuefu Zhuyu decoction in the treatment of diabetic kidney disease (DKD), providing evidence-based support.
Review
Endocrinology & Metabolism
Amir Hossein Behnoush, Parnian Shobeiri, Pegah Bahiraie, Nikan Amirkhani, Amirmohammad Khalaji, Soheil Peiman
Summary: This systematic review and meta-analysis found that chemerin levels were significantly higher in patients with chronic kidney disease (CKD) compared to healthy controls. These findings suggest that chemerin may serve as a biomarker in CKD patients and provide insights into the pathophysiology of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Shaomin Shi, Lihua Ni, Ling Gao, Xiaoyan Wu
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes, but nonalbuminuric diabetic kidney disease (NADKD) has been increasingly reported in diabetic patients. NADKD patients have different clinical characteristics and pathology compared to albuminuric DKD, and require different diagnostic and treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Carlo Garofalo, Chiara Ruotolo, Claudia Annoiato, Maria Elena Liberti, Roberto Minutolo, Luca De Nicola, Giuseppe Conte, Silvio Borrelli
Summary: A systematic review and meta-analysis revealed that approximately 1.5% of patients undergoing maintenance dialysis experience recovery of kidney function unrelated to acute kidney injury. The prevalence of recovery is higher in the United States compared to other countries.
Article
Urology & Nephrology
Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P. C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joachim Jankowski, Leticia Prates Roma, Heidi Noels
Summary: Chronic kidney disease (CKD) increases the risk of developing uremic cardiomyopathy, and animal studies are used to investigate the underlying mechanisms. This review systematically analyzed 88 studies and performed meta-analyses of 52 to identify suitable animal models for future experimental studies. The results showed variations in different mouse strains and the effects of CKD on cardiac hypertrophy, fibrosis, and function. Multifactorial hit models consistently induced cardiac hypertrophy and fibrosis compared to single hit kidney injury models.
KIDNEY INTERNATIONAL
(2022)
Review
Urology & Nephrology
Caroline Liu, Neha Debnath, Gohar Mosoyan, Kinsuk Chauhan, George Vasquez-Rios, Celine Soudant, Steve Menez, Chirag R. Parikh, Steven G. Coca
Summary: Sensitive and specific biomarkers are needed to better understand the risk of incident and progressive CKD. A systematic review and meta-analysis were conducted to assess the prognostic value of preclinical plasma and urine biomarkers for CKD outcomes. The most frequently studied biomarkers (TNFR1, FGF23, TNFR2, KIM-1, suPAR, KIM-1, NGAL) showed significant associations with CKD outcomes. These findings suggest these biomarkers should be assessed in clinical practice.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Medicine, General & Internal
Ching-Chun Su, Jui-Yi Chen, Sheng-Yin Chen, Chih-Chung Shiao, Javier A. Neyra, Ryo Matsuura, Eisei Noiri, Emily See, Yih-Ting Chen, Cheng-Kai Hsu, Heng-Chih Pan, Chih-Hsiang Chang, Mitchell H. Rosner, Vin-Cent Wu
Summary: This study conducted a meta-analysis of 21 studies involving 1,114,012 patients and found that patients with acute kidney disease (AKD) have poorer outcomes, including higher mortality rates, increased risk of end-stage kidney disease (ESKD), and higher incidence of chronic kidney disease (CKD). Additionally, the study found that AKD can also occur in patients without prior acute kidney injury (AKI).
Review
Plant Sciences
Baohui Fu, Zongjie Shang, Simian Song, Yupei Xu, Lijuan Wei, Ge Li, Hongtao Yang
Summary: This study evaluated the safety of Niaoduqing granules (NDQG) in the treatment of kidney diseases. The results showed that the frequency of adverse drug reactions (ADRs) of NDQG was similar to the control group, with common ADRs mainly affecting the gastrointestinal and nervous systems, presenting as diarrhea, nausea, and vomiting. More high-quality studies are needed to establish the safety of NDQG.
Review
Pharmacology & Pharmacy
Yichuan Wu, Huanjia Lin, Yuan Tao, Ying Xu, Jiaqi Chen, Yijie Jia, Zongji Zheng
Summary: This network meta-analysis evaluated the efficacy and safety of different types of MRAs in patients with diabetic kidney disease. The results showed that finerenone, esaxerenone, and apararenone were associated with a significant reduction in proteinuria, and finerenone may have potential superiority in kidney protection. None of the treatments were associated with a higher probability of controlling systolic blood pressure compared to placebo. However, spironolactone, esaxerenone, and 20 mg finerenone presented a higher risk of hyperkalemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Constance C. F. M. J. Baaten, Marieke Sternkopf, Tobias Henning, Nikolaus Marx, Joachim Jankowski, Heidi Noels
Summary: Most studies report impaired platelet function in patients with chronic kidney disease, but a substantial number find platelet function unchanged or even enhanced. Further investigation of platelet reactivity in CKD, especially during different stages, is needed.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Medicine, Research & Experimental
Jagmeet Singh, Preeti Malik, Nidhi Patel, Suveenkrishna Pothuru, Avantika Israni, Raja Chandra Chakinala, Maryam Rafaqat Hussain, Anusha Chidharla, Harshil Patel, Saurabh Kumar Patel, Rizwan Rabbani, Urvish Patel, Savneek Chugh, Asim Kichloo
Summary: The study conducted a meta-analysis and found significant associations between comorbid CKD, AKI, and CRRT utilization with the severity of COVID-19 disease, with higher occurrence rates in severe cases.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Integrative & Complementary Medicine
Jing Hu, Shuo Feng, Xiaoli Zhang, Huina Zhang, Yanxiang Ha, Chongyang Wei, Xuejiao Wang, Rui Zhang, Xing Liao, Bo Li
Summary: Multiple primary outcomes are commonly used in Chinese herbal medicine RCTs, but appropriate methods for adjusting multiplicity are often not utilized, and sample size estimation based on multiple primary outcomes is lacking. The explicit reporting of primary outcomes is associated with nationality, research area, and sample size.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Tae-Hun Kim, Zi-Yu Tian, Xing Liao, Nicola Robinson
Summary: This paper provides a researcher's guide to the structure and essential elements of conducting an overview of SRs in T&CM. Through a narrative literature review and analysis of articles published in EuJIM, three key elements were identified and a lack of clear guidance for conducting overviews was observed.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Developmental Biology
Ruidan Zhang, Bingbing Wu, Chao Liu, Zhe Zhang, Xiuge Wang, Liying Wang, Sai Xiao, Yinghong Chen, Huafang Wei, Hui Jiang, Fei Gao, Li Yuan, Wei Li
Summary: The interaction between CCDC38 and CCDC42 is crucial for sperm flagellum biogenesis, and their deficiency leads to abnormalities in sperm flagella and male sterility.
Article
Integrative & Complementary Medicine
Huimin Li, Ruixue Hu, Simin Xu, Zeqi Dai, Xue Wu, Jing Hu, Xing Liao
Summary: By comprehensively evaluating the related systematic reviews, this overview found that there are methodological issues, risk of bias, and reporting deficiencies in the use of Tripterygium wilfordii Hook. f. preparations for the treatment of rheumatoid arthritis (RA). However, moderate-quality evidence suggests that these preparations may be clinically effective in treating RA.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Yunyun Zhao, Guanchi Yan, Di Jin, Xiaolin Tong, Xiuge Wang
Summary: In this study, we used network pharmacology, molecular docking, and in vitro experiments to investigate the mechanism of BPCM in treating T2DM. The results showed that BPCM may promote AMPK/ACC conduction and inhibit lipid accumulation.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Endocrinology & Metabolism
Jiahua Wei, Jiaxing Tian, Cheng Tang, Xinyi Fang, Runyu Miao, Haoran Wu, Xiuge Wang, Xiaolin Tong
Summary: This article discusses the most serious complication of diabetes, vascular complications, and provides a detailed analysis of the pathogenesis of type 1 and type 2 diabetes, as well as an explanation for the different trends in the progression of different types of diabetes into vascular complications.
JOURNAL OF DIABETES RESEARCH
(2022)
Review
Mathematical & Computational Biology
Yunyun Zhao, Guanchi Yan, Jia Mi, Guoqiang Wang, Miao Yu, Di Jin, Xiaolin Tong, Xiuge Wang
Summary: By conducting a systematic review and computational analysis of lncRNA in diabetic kidney disease (DKD), this study identified several dysregulated lncRNAs associated with the disease and determined their involvement in disease-related signal pathways.
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
(2022)
Review
Integrative & Complementary Medicine
Ruixue Hu, Huimin Li, Simin Xu, Zeqi Dai, Yongyan Wang, Xing Liao
Summary: This systematic review evaluated the efficacy, safety, and treatment costs of Lanqin oral liquid (LOL) for children with hand, foot, and mouth disease. The study found that LOL can reduce the clearance time for fever, skin eruptions, and mouth herpes or ulcers, and improve the total effective rate and immune function. However, most of the included studies had a high risk of bias, and there were few studies on treatment costs.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Respiratory System
Lin Feng, Xiaoshuang Lv, Yingquan Wang, Shuilian Chu, Zeqi Dai, Hang Jing, Zhaohui Tong, Xing Liao, Lirong Liang
Summary: This article conducted a scoping review of smoking cessation interventions for COPD patients, and found that the current methods have limited effectiveness in COPD patients. Most of the studies explored new treatment strategies, such as extended treatment and the use of mobile health. They suggested that pharmacotherapy combined with mHealth showed promise for helping COPD smokers quit. However, the overall quality of the existing studies is poor, and more high-quality research is needed.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Integrative & Complementary Medicine
Ruixue Hu, Huimin Li, Simin Xu, Zeqi Dai, Yongyan Wang, Xing Liao
Summary: This study provides an overview of the development trends in research on the use of arsenic for acute promyelocytic leukemia (APL). The clinical efficacy and mechanism of arsenic treatment for APL have been the main focuses of research, while the APL differentiation syndrome and drug resistance are the current hotspots. Huangdai tablets, arsenious acid, and all-trans retinoic acid are identified as the main drugs of interest in this field.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Review
Chemistry, Medicinal
Di Jin, Jing Wang, Jiaojiao Xue, Yunyun Zhao, Guanchi Yan, Xiangyan Li, Xiuge Wang
Summary: This study evaluates the efficacy and safety of Chinese herbal medicine (CHM) in the treatment of COVID-19 through a meta-analysis. The results show that CHM can improve lung CT, clinical cure rate, clinical symptom score, and time to negative for viral nucleic acid. However, more high-quality randomized controlled trials are needed to provide more reliable evidence.
PHYTOTHERAPY RESEARCH
(2023)
Review
Integrative & Complementary Medicine
Xue Wu, ZeQi Dai, ChengYang Jing, MiaoMiao Li, Le Zhang, Xing Liao
Summary: In China, the use of Chinese patent medicines (CPMs) for children with respiratory and/or digestive diseases is increasing, but little is known about their overall impact on these diseases and co-morbidities. This scoping review aims to systematically identify and map available research evidence on the use of CPMs for children with RDDs and co-morbid RDDs, explore research gaps, and drive further research.
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.