Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats

Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications

(2022) Alexandria N. Tartt et al.   MOLECULAR PSYCHIATRY

SiNiSan alleviates liver injury by promoting hepatic stem cell differentiation via Wnt/β-catenin signaling pathway

(2022) Weidong Xu et al.   PHYTOMEDICINE

Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

(2022) Chen-Yue Liu et al.   Chinese Medicine

Stress Reduces Extracellular ATP in the Prefrontal Cortex and Activates the Prefrontal Cortex–Lateral Habenula Pathway for Depressive-like Behavior

(2022) Emily Arzola et al.   BIOLOGICAL PSYCHIATRY

Adult neurogenesis and antidepressant treatment; the surprise finding by Ron Duman and the field 20 years later

(2021) Jessica E. Malberg et al.   BIOLOGICAL PSYCHIATRY

Mitochondria and Early-Life Adversity

(2021) Emily K. Zitkovsky et al.   MITOCHONDRION

Deciphering the synergistic network regulation of active components from SiNiSan against irritable bowel syndrome via a comprehensive strategy: Combined effects of synephrine, paeoniflorin and naringin

(2021) Tingting Cai et al.   PHYTOMEDICINE

The relevance of mitochondrial morphology for human disease

(2021) Tharsini Navaratnarajah et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Depression promotes lung carcinoma progression by regulating the tumor microenvironment in tumor-bearing models of C57BL/6J mice

(2021) Sainan Cui et al.   NEUROSCIENCE LETTERS

Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation

(2021) Yajie Cai et al.   PHYTOMEDICINE

Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: Does inflammation play a role?

(2021) Giselli Scaini et al.   MOLECULAR PSYCHIATRY

Energy matters: presynaptic metabolism and the maintenance of synaptic transmission

(2021) Sunan Li et al.   NATURE REVIEWS NEUROSCIENCE

Surgery/Anesthesia disturbs mitochondrial fission/fusion dynamics in the brain of aged mice with postoperative delirium

(2020) Yayuan Lu et al.   Aging-US

Early-Life Stress Induces Depression-Like Behavior and Synaptic-Plasticity Changes in a Maternal Separation Rat Model: Gender Difference and Metabolomics Study

(2020) Yongfei Cui et al.   Frontiers in Pharmacology

SiNiSan ameliorates depression-like behavior in rats by enhancing synaptic plasticity via the CaSR-PKC-ERK signaling pathway

(2020) Chongkun Shen et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of glucocorticoid receptor phosphorylation-mediated synaptic plasticity in anxiogenic and depressive behaviors induced by monosodium glutamate

(2020) Wen Zhu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Quantitative proteomic analysis of the liver reveals antidepressant potential protein targets of Sinisan in a mouse CUMS model of depression

(2020) Baoying Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Metabolomics study on the therapeutic effect of the Chinese herb pair Fructus Aurantii Immaturus and Rhizoma Atractylodis Macrocephalae in constipated rats based on UPLC-Q/TOF-MS analysis

(2020) Shuai Yan et al.   Annals of Palliative Medicine

Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior

(2020) Anfeng Wang et al.   Frontiers in Genetics

Intravenous administration of adenosine triphosphate and phosphocreatine combined with fluoxetine in major depressive disorder: protocol for a randomized, double-blind, placebo-controlled pilot study

(2019) Yiyi Chen et al.   Trials

Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function

(2019) Ronald S. Duman et al.   MOLECULAR PSYCHIATRY

SiNiSan Ameliorates the Depression-Like Behavior of Rats That Experienced Maternal Separation Through 5-HT1A Receptor/CREB/BDNF Pathway

(2019) Kerun Cao et al.   Frontiers in Psychiatry

Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors

(2019) Yun Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response

(2019) Lily R. Aleksandrova et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A Critical Role of Mitochondria in BDNF-Associated Synaptic Plasticity After One-Week Vortioxetine Treatment

(2018) Fenghua Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Maternal separation blunted spatial memory formation independent of peripheral and hippocampal insulin content in young adult male rats

(2018) Soheila Maghami et al.   PLoS One

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic fluoxetine administration enhances synaptic plasticity and increases functional dynamics in hippocampal CA3-CA1 synapses

(2017) Dina Popova et al.   NEUROPHARMACOLOGY

Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation

(2017) Hossein Amini-Khoei et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

(2016) Audrey R. Tyrka et al.   BIOLOGICAL PSYCHIATRY

A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent

(2016) Tae Ho Lee et al.   JOURNAL OF NEUROCHEMISTRY

Early Stress History Alters Serum Insulin-Like Growth Factor-1 and Impairs Muscle Mitochondrial Function in Adult Male Rats

(2016) S. Ghosh et al.   JOURNAL OF NEUROENDOCRINOLOGY

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

(2016) A.M. Bertholet et al.   NEUROBIOLOGY OF DISEASE

Early stress evokes dysregulation of histone modifiers in the medial prefrontal cortex across the life span

(2015) Madhavi Pusalkar et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Changed Synaptic Plasticity in Neural Circuits of Depressive-Like and Escitalopram-Treated Rats

(2015) Xiao-Li Li et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Fluoxetine regulates mTOR signalling in a region-dependent manner in depression-like mice

(2015) Xiao-Long Liu et al.   Scientific Reports

Regional differences in acute corticosterone-induced dendritic remodeling in the rat brain and their behavioral consequences

(2014) Hyejin Kim et al.   BMC NEUROSCIENCE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of thienorphine on synaptic structure and synaptophysin expression in the rat nucleus accumbens

(2014) Z. Yong et al.   NEUROSCIENCE

Regulation of Neurotrophic Factors and Energy Metabolism by Antidepressants in Astrocytes

(2013) Jean-Luc Martin et al.   CURRENT DRUG TARGETS

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity

(2011) Weifeng Xu   CURRENT OPINION IN NEUROBIOLOGY

Synaptophysin Regulates the Kinetics of Synaptic Vesicle Endocytosis in Central Neurons

(2011) Sung E. Kwon et al.   NEURON

The gray area between synapse structure and function-Gray's synapse types I and II revisited

(2011) Cornelius J.H.M. Klemann et al.   SYNAPSE

Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication I

(2010) Jennifer Greif Green et al.   ARCHIVES OF GENERAL PSYCHIATRY

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON