Antimicrobial abietane-type diterpenoids from Torreya grandis

Twelve undescribed abietane-type diterpenoids, along with ten known analogues were isolated from the twigs and leaves of Torreya grandis var. merrillii Hu. Their structures were characterized by spectroscopic data analyses, single-crystal X-ray diffraction, and ECD spectra. Torgranols A-C possess three different architectures shaped via a common 6,7-seco-procedure and subsequent ring formations. In particular, torgranol A represents the first example of a 6,7-seco-abietane diterpenoid featuring a unique oxygen bridge between C-3 and C-6. The biosynthetic pathways for torgranols A-C were proposed. Some compounds displayed antimicrobial activities against Mycobacterium tuberculosis and/or Staphylococcus aureus.

Automated summary

Twelve undescribed abietane-type diterpenoids, along with ten known analogues, were isolated from the twigs and leaves of Torreya grandis var. merrillii Hu. Their structures and biosynthetic pathways were characterized. Some compounds exhibited antimicrobial activities.