期刊
ORGANIC LETTERS
卷 24, 期 38, 页码 6962-6967出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02768
关键词
-
资金
- National Natural Science Foundation of China [21901185]
- Tianjin Normal University
Here we report a three-component 1,2-arylboration of alkenyl amines featuring a cleavable picolinamide directing group. The reaction exhibits high levels of chemo- and regiocontrol and shows excellent tolerance towards various functional groups.
We report herein a three-component 1,2-arylboration of alkenyl amines bearing a cleavable picolinamide directing group. With aryl halides as electrophiles and B2Pin2 as nucleophiles, a wide range of alkenes could be converted into valuable boryl-functionalized aliphatic amines. The reaction proceeds with high levels of chemo-and regiocontrol and exhibits high functional group tolerance. In addition, the pinacol boronic ester group could undergo various transformations, indicating that the protocol could potentially provide a platform for versatile regioselective difunctionalization of alkenyl amines.
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