Article
Gastroenterology & Hepatology
Natasha Haskey, Jiayu Ye, Mehrbod Estaki, Andrea A. Verdugo Meza, Jacqueline A. Barnett, Mitra Yousefi, Blake W. Birnie, Samantha Gruenheid, Sanjoy Ghosh, Deanna L. Gibson
Summary: There is a growing awareness of the interaction between diet, gut microbiota, and the immune system in the development of inflammatory bowel disease (IBD). High-fat diets have been shown to exacerbate IBD, while the fat blend found in the Mediterranean diet (MD) may have protective effects. A study in mice found that a diet mimicking the MD fat blend reduced disease activity and inflammation, and improved metabolic parameters in a mouse model of IBD.
Article
Biochemistry & Molecular Biology
Jiuxi Liu, Jiapei Cai, Peng Fan, Xue Dong, Naisheng Zhang, Jiandong Tai, Yongguo Cao
Summary: Salidroside, a glycoside extracted from Rhodiola rosea L., was found to ameliorate dextran sulfate sodium (DSS)-induced colitis by modulating the gut microbiota. Salidroside treatment inhibited colitis symptoms in mice, including colon length, histology, disease activity index (DAI) score, and macrophage levels in the intestine. In a fecal microbiota transplantation (FMT) study, fecal samples from Salidroside-treated mice significantly alleviated colitis symptoms in recipient mice, indicating the importance of gut microbiota in the therapeutic effect. Salidroside and FMT both influenced the structure and abundance of the gut microbiota, with decreased relative abundance of Turicibacter, Alistipes, Romboutsia, and increased relative abundance of Lactobacillus. The anti-inflammatory effect of Salidroside was dependent on the presence of gut microbiota, as evidenced by its disappearance in antibiotic-treated mice. Salidroside could be a promising functional food for colitis treatment.
Article
Immunology
Maryam Ranjbar Bushehri, Nahid Babaei, Hadi Esmaeili Gouvarchin Ghaleh, Gholamreza Khamisipour, Gholamreza Farnoosh
Summary: This study investigates the anti-inflammatory effects of peiminine on ulcerative colitis. The results demonstrate that peiminine treatment can alleviate inflammatory manifestations, reduce intestinal tissue damage, and affect gene expression. Peiminine holds potential as a therapeutic adjunct for the management of ulcerative colitis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Atieh Yaghoubi, Saeid Amel Jamehdar, Mohammad Reza Akbari Eidgahi, Kiarash Ghazvini
Summary: This study found that melittin peptide, alone or in combination with sulfasalazine, significantly cured clinical ulcerative colitis and attenuated inflammation and tissue damage in colon tissue. Furthermore, this peptide had an antioxidant effect by disrupting the oxidant/antioxidant balance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Heba M. Hafez, Mohamed A. Ibrahim, Walaa Yehia Abdelzaher, Alyaa A. Gad, Sara Mohammed Naguib Abdel Hafez, Seham A. Abdel-Gaber
Summary: The study found that MRT has a protective effect against UC by reducing colonic damage and oxidative stress, as well as modulating the NLRP3/caspase-1 inflammatory pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Antonietta Gerarda Gravina, Marcello Dallio, Mario Romeo, Raffaele Pellegrino, Paola Stiuso, Stefania Lama, Paolo Grieco, Francesco Merlino, Iacopo Panarese, Federica Zito Marino, Moris Sangineto, Marco Romano, Alessandro Federico
Summary: This study assessed the relationship between Urotensin-II receptor (UTR) expression and the clinical, endoscopic, and biochemical severity of ulcerative colitis (UC), as well as its predictive value for intravenous steroid administration. The results showed that UTR expression was higher in the lesioned mucosa of UC patients compared to healthy subjects, and it was directly related to disease severity. UTR expression was also higher in patients requiring iv steroids administration and was predictive of the therapeutic outcome.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Immunology
Cuipeng Zhu, Kaiqi Li, Xiao-Xu Peng, Tong-Jia Yao, Zi-Yu Wang, Ping Hu, Demin Cai, Hao-Yu Liu
Summary: Berberine (BBR), an alkaloid extracted from Coptidis Rhizoma, has various pharmacological properties including anti-inflammatory, antibacterial, antioxidant, anti-obesity, and even antitumor effects. Recent studies have also focused on the modulatory effects of BBR on nutritional immune responses. This mini-review summarizes the latest research on the inflammation, gut microbes, macrophage polarization, and immune responses related to BBR's tools in the pathogenesis and therapy of ulcerative colitis and cancer in the past 5 years. The therapeutic efficacy and anti-inflammatory actions of BBR are also discussed for future clinical applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Armita Farid, Mohammad Sheibani, Asie Shojaii, Mitra Noori, Manijeh Motevalian
Summary: The leaf extract of Plantago major exhibits anti-inflammatory effects and protects against mucosal damage in rats with ulcerative colitis, especially when administered in high doses. The seed extract of P. major has minimal protective effects on ulcerative colitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaodong Li, Xia Wu, Qi Wang, Weilv Xu, Qingwei Zhao, Nana Xu, Xingjiang Hu, Ziqi Ye, Songxia Yu, Jian Liu, Xuelin He, Fushan Shi, Qiao Zhang, Weifen Li
Summary: The study found that sanguinarine (SAN) has a therapeutic effect on ulcerative colitis (UC) by blocking the NLRP3-(Caspase-1)/IL-1 beta pathway and improving intestinal microbial dysbiosis.
Article
Immunology
Min Li, Lulu Lan, Si Zhang, Yanjiao Xu, Wenxi He, Dong Xiang, Dong Liu, Xiuhua Ren, Chengliang Zhang
Summary: Ulcerative colitis is associated with increased inflammatory factors affecting drug metabolism in the liver. IL-6 inhibits hepatic CESs via the NF-kappa B pathway, leading to potential drug disposition issues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aurora Mazzei, Grazia Serino, Alessandro Romano, Emanuele Piccinno, Viviana Scalavino, Anna Maria Valentini, Raffaele Armentano, Roberta Schiavone, Gianluigi Giannelli, Tiziano Verri, Amilcare Barca
Summary: SLC15A4/PHT1 has been identified as a key path marker of immune/autoimmune/inflammatory pathways in immune cells, and this study found its overexpression in the colonic epithelium of ulcerative colitis (UC) patients. In vitro experiments successfully mirrored the inflammatory onset in spontaneously differentiated enterocyte-like monolayers of Caco-2 cells specifically exposed to DSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ilyssa O. Gordon, Suha Abushamma, Jacob A. Kurowski, Stefan D. Holubar, Lei Kou, Ruishen Lyu, Florian Rieder
Summary: This study found that pediatric patients with ulcerative colitis exhibit colorectal submucosal fibrosis and muscularis mucosa thickening, which correlate with the presence, chronicity, and degree of mucosal inflammation.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biochemistry & Molecular Biology
Yan-Ting Wu, Li-Shan Zhong, Chen Huang, Yu-Ying Guo, Fu-Jun Jin, Yu-Ze Hu, Zi-Bo Zhao, Zhe Ren, Yi-Fei Wang
Summary: Macrophage ferroptosis is a potential therapeutic target for ulcerative colitis (UC), and beta-caryophyllene (BCP) has been identified as an effective inhibitor of macrophage lipid peroxidation and inflammation. BCP activates the type 2 cannabinoid receptor (CB2R) to inhibit macrophage ferroptosis and its induced inflammatory response both in vivo and in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Zhihao Han, Yi Li, Xin Wang, Chang Li, Changsheng Li, Qiao Lin, Enping Xu, Jinlong Tang, Maode Lai, Yi Ma, Yueqing Gu
Summary: Currently, the staging of colorectal cancer (CRC) relies on ex vivo pathologic analysis which is invasive and limits sample collection. In this study, key biomarkers VEGFR2 and PTGER4 were selected based on their expression patterns in different stages of CRC. Molecular probes were constructed, and the feasibility of in vivo noninvasive CRC staging using confocal laser endoscopy (CLE) was demonstrated in mouse models. This strategy shows promise in providing precise pathological staging for CRC patients and guiding therapeutic strategies.
ANALYTICAL CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Luca Massimino, Orazio Palmieri, Amanda Facoetti, Davide Fuggetta, Salvatore Spano, Luigi Antonio Lamparelli, Silvia D'Alessio, Stefania Cagliani, Federica Furfaro, Ferdinando D'Amico, Alessandra Zilli, Gionata Fiorino, Tommaso Lorenzo Parigi, Daniele Noviello, Anna Latiano, Fabrizio Bossa, Tiziana Latiano, Alessandra Pirola, Luca Mologni, Rocco Giovanni Piazza, Danilo Abbati, Francesco Perri, Chiara Bonini, Laurent Peyrin-Biroulet, Alberto Malesci, Vipul Jairath, Silvio Danese, Federica Ungaro
Summary: This study found that the virome-associated protein encoded by the hepatitis B virus (HBx) is detected in about 45% of patients with ulcerative colitis (UC) and is associated with UC progression. Experimental findings showed that HBx induces colonic inflammation and its silencing reverses the colitis phenotype. HBx acts as a transcriptional regulator in epithelial cells, leading to barrier leakage and altering mucosal immunity. This study provides a new perspective on targeted treatments for the virome composition of the gut microbiota.