期刊
NEUROBIOLOGY OF AGING
卷 118, 期 -, 页码 9-12出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2022.04.016
关键词
Aging; Cerebellum; Primary motor cortex; Cerebellar inhibition; Transcranial magnetic stimulation
资金
- National Institutes of Health [R01HD053793]
Effective connectivity between the cerebellum and primary motor cortex is crucial for motor learning and control. Despite age-related declines in motor abilities, recent studies indicate that older adults may maintain or even enhance cerebellar-dependent motor learning processes. This study reveals stronger cerebellar inhibition in older adults compared to young adults, suggesting enhanced cerebellar-M1 connectivity with advanced age.
Effective connectivity between the cerebellum and primary motor cortex (M1) is critical for motor learning and motor control. Despite evidence of cerebellar atrophy and declines in motor learning and motor control with advanced age, recent behavioral studies indicate that cerebellar-dependent motor learning processes are preserved or even enhanced in older adults. However, physiological evidence of heightened cerebellar excitability leading to strengthened cerebellar-M1 connectivity with advanced age is lacking. Here, we used transcranial magnetic stimulation to assess age-related effects on cerebellar inhibition, a measure of cerebellar-M1 connectivity, in 20 young and 19 older adults. We observed stronger cerebellar inhibition in older compared with young adults. The behavioral implications of strengthened cerebellar inhibition with advanced age found in this study remain to be determined.(c) 2022 Elsevier Inc. All rights reserved.
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