SARS-CoV-2 fires up inflammation in adipose tissue

Obesity is an important risk factor for severe COVID-19 and, possibly, for breakthrough SARS-CoV-2 infections in fully vaccinated people. Novel findings highlight how SARS-CoV-2 infects adipose tissue and promotes subclinical inflammation. Thus, also based on knowledge about endocrine dysfunction facilitating SARS-CoV-2 infection, a vicious cycle involving obesity, impaired metabolic health and COVID-19 might exist.

Automated summary

Obesity is an important risk factor for severe COVID-19 and breakthrough SARS-CoV-2 infections in fully vaccinated individuals, possibly indicating a vicious cycle.