期刊
MOLECULES
卷 27, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules27196773
关键词
cannabidiol; endocannabinoid system; enteric glial cells; enteric nervous system; gastrointestinal system; nutraceuticals; palmitoylethanolamide
资金
- Ministerio de Ciencia, Innovacion y Universidades [PID2019-111510RB-I00]
- Medical University of Lodz [503/1-156-04/503-11-001-19-00]
The enteric nervous system and endogenous cannabinoid system play important roles in the proper functioning of the gastrointestinal tract. The enteric glial cells contribute to maintaining gastrointestinal homeostasis and can be modulated by the components of the endogenous cannabinoid system. Understanding the interaction between these systems could lead to new therapeutic approaches for gastrointestinal dysfunctions.
The enteric nervous system (ENS) is a part of the autonomic nervous system that intrinsically innervates the gastrointestinal (GI) tract. Whereas enteric neurons have been deeply studied, the enteric glial cells (EGCs) have received less attention. However, these are immune-competent cells that contribute to the maintenance of the GI tract homeostasis through supporting epithelial integrity, providing neuroprotection, and influencing the GI motor function and sensation. The endogenous cannabinoid system (ECS) includes endogenous classical cannabinoids (anandamide, 2-arachidonoylglycerol), cannabinoid-like ligands (oleoylethanolamide (OEA) and palmitoylethanolamide (PEA)), enzymes involved in their metabolism (FAAH, MAGL, COX-2) and classical (CB1 and CB2) and non-classical (TRPV1, GPR55, PPAR) receptors. The ECS participates in many processes crucial for the proper functioning of the GI tract, in which the EGCs are involved. Thus, the modulation of the EGCs through the ECS might be beneficial to treat some dysfunctions of the GI tract. This review explores the role of EGCs and ECS on the GI tract functions and dysfunctions, and the current knowledge about how EGCs may be modulated by the ECS components, as possible new targets for cannabinoids and cannabinoid-like molecules, particularly those with potential nutraceutical use.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据