期刊
MEDIATORS OF INFLAMMATION
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/3121492
关键词
-
资金
- Education Department of Jilin Province 13th Five-Year Science and Technology Research Planning Project
- [JJKH20200054KJ]
miR-559 interacts with PARD3 in hepatocellular carcinoma cells, affecting cell proliferation, autophagy, and angiogenesis. PARD3 is a target of miR-559, and inhibition of miR-559 leads to increased expression of PARD3, enhancing the biological characteristics of HCC cells.
Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and has a high mortality rate. Although prevention and treatment of HCC has improved, it still faces poor prognosis and high mortality. miRNAs play a critical role in the tumorigenesis of HCC, but the underlying mechanism has not been well investigated. Here, the functions and interaction between miR-559 and PARD3 were investigated in HCC cells. Increased PARD3 and decreased miR-559 expression were observed in HCC cells compared with those in normal liver cells, especially in Huh-7 cells. Studies further demonstrated that PARD3 silencing or miR-559 overexpression impaired the proliferation, autophagy, and angiogenesis in Huh-7 cells. Mechanistically, PARD3 represents a target of miR-559. Furthermore, investigations revealed that miR-559 inhibition induced the expression of PARD3, thereby enhancing cell proliferation, autophagy, and angiogenesis in Huh-7 cells. These results reveal the interaction between miR-559 and PARD3 in HCC cells and provide new insights into their potential targets as therapeutic treatment against HCC.
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