Article
Chemistry, Multidisciplinary
Supphachok Chanmungkalakul, Chao Wang, Rong Miao, Weijie Chi, Davin Tan, Qinglong Qiao, Esther Cai Xia Ang, Choon-Hong Tan, Yu Fang, Zhaochao Xu, Xiaogang Liu
Summary: A simple descriptor, Delta E, was developed to predict host molecules matching with guest RTP emitters with high accuracy. This matching enabled the achievement of multi-layer message encryption.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Xi Yan, Hao Peng, Yuan Xiang, Juan Wang, Lan Yu, Ye Tao, Huanhuan Li, Wei Huang, Runfeng Chen
Summary: Research focus in the field of organic electronics is currently on the design and characterization of purely organic room-temperature phosphorescent (RTP) materials. Host-guest material systems, with the ability to control and modulate properties, are promising candidates for high-performance RTP materials with diverse applications.
Article
Materials Science, Multidisciplinary
Yonghui Sun, Linnan Jiang, Lijuan Liu, Yong Chen, Wen-Wen Xu, Jie Niu, Yuexiu Qin, Xiufang Xu, Yu Liu
Summary: Two kinds of amorphous solid-state supramolecular systems with purely organic room temperature phosphorescence (RTP) were reported, which were activated by calix[3]phenothiazine (C[3]Pz) and 1,2-/1,3-dicyanobenzene (1,2-/1,3-DCB). The RTP of these supramolecular systems was entirely from the interaction between 1,2-/1,3-DCB and C[3]Pz, forming dense supramolecular complexes, leading to two different phosphorescence emissions. The use of 1,2-DCB and 1,3-DCB as molecular rivets fixed the C[3]Pz, inhibiting molecular vibration and reducing nonradiative relaxation, resulting in effective RTP emission with high quantum yields.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jinzhu Cao, Meng Zhang, Manjeet Singh, Zhongfu An, Lingfei Ji, Huifang Shi, Yijian Jiang
Summary: Remarkable progress has been made in the development of host-guest doped pure organic room-temperature phosphorescence materials. The study successfully developed a heavy atom free pure organic molecular doped system with efficient RTP and optimized doping ratios to achieve high quantum efficiency and long lifetime RTP emission. This work provides an effective way to design new organic doping systems with RTP.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yang Xia, Chenfei Zhu, Feng Cao, Yunxia Shen, Mi Ouyang, Yujian Zhang
Summary: This study proposes a host-guest doping strategy to achieve both room-temperature phosphorescence (RTP) and flexibility in organic single crystals (OSCs). The flexible OSCs exhibit bright deep-red phosphorescence upon external force application and can return to their original shape after stress removal. The results suggest that the bright RTP is due to Forster resonance energy transfer (FRET) from the triphenylene molecules to the dopants. This strategy provides a simple and universal approach for the preparation of flexible OSCs with RTP.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Zongliang Xie, Xiayu Zhang, Hailan Wang, Cheng Huang, Haodong Sun, Mengyang Dong, Lei Ji, Zhongfu An, Tao Yu, Wei Huang
Summary: This study reported a multi-host/guest ultralong organic phosphorescence system with wide-ranging tunable lifetime via changing the host matrix, showing great potential for various applications.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Biao Chen, Wenhuan Huang, Xiancheng Nie, Fan Liao, Hui Miao, Xuepeng Zhang, Guoqing Zhang
Summary: The study achieved the efficient production of long-lived red organic room-temperature phosphorescence at extremely low concentrations by using naphthalimide fluorescent dyes in phthalimide hosts. This finding holds potential applications in molecular solids.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Dan Wang, Yufeng Xie, Xinghui Wu, Yunxiang Lei, Yunbing Zhou, Zhengxu Cai, Miaochang Liu, Huayue Wu, Xiaobo Huang, Yuping Dong
Summary: A series of organic host-guest materials with multifunctional luminescence were constructed, exhibiting three-color emission switching among cyan, white, and orange. The materials could be used as writable inks for advanced anticounterfeiting.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Yunxiang Lei, Wenbo Dai, Gengchen Li, Yongfeng Zhang, Xiaobo Huang, Zhengxu Cai, Yuping Dong
Summary: Small molecular host-guest doped materials have advantages in high-efficiency room-temperature phosphorescence (RTP) due to their diverse structural design and easy preparation. Dynamic RTP materials show excellent characteristics, such as reversibility, quick response, and tunable luminescence ability, making them applicable in cutting-edge technologies. This Perspective summarizes the advances in host-guest doped dynamic RTP materials that respond to external and internal stimuli and provides insights into molecular design strategies and mechanisms. It is highly beneficial for the future intelligent applications of dynamic RTP systems.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Yunsheng Wang, Mingxue Gao, Jia Ren, Jiayi Liang, Yao Zhao, Manman Fang, Jie Yang, Zhen Li
Summary: The development of multifunctional luminescent materials is important but difficult due to different requirements for molecular structure in different luminescent properties. This study reported a universal exciplex platform to construct multifunctional luminescent materials, including thermally-activated delayed fluorescence (TADF), persistent room temperature phosphorescence (RTP) and mechanoluminescence (ML). The exciplex system, using compound PTZ-CN as an electron donor and its derivative of OPTZ-CN as an electron acceptor, showed efficient TADF with a quantum yield of up to 61%, persistent RTP lasting for more than 3 minutes, and bright blue ML emission. Thus, this work opens a new way for the construction of multifunctional luminescent materials, which will greatly promote further development in this research area.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Multidisciplinary Sciences
Fuming Xiao, Heqi Gao, Yunxiang Lei, Wenbo Dai, Miaochang Liu, Xiaoyan Zheng, Zhengxu Cai, Xiaobo Huang, Huayue Wu, Dan Ding
Summary: Organic room temperature phosphorescence materials with long wavelengths and long lifetimes have been successfully obtained through the guest-host doped strategy. These materials exhibit good tissue penetration and enable successful tumor imaging in living mice.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Zitong Li, Bingbing Ding, Xiaoqin Liu, Linbing Sun, Xiang Ma
Summary: A series of polymers containing S/Se-naphthalimide derivatives were prepared, showing decent RTP properties in both solid state and aqueous solution, laying a foundation for enhancing the luminescence performance of RTP materials.
Article
Chemistry, Applied
Chunhui Li, Jinkang Zhu, Qiaochun Wang
Summary: Researchers have successfully encapsulated 1-methyl-4-phenylpyridin-1-ium salts into phCB[6], forming complexes that emit phosphorescence at high temperatures, showing potential for further applications.
Article
Materials Science, Multidisciplinary
Yitian Jiang, Chenyu Zhang, Ruoxi Wang, Yunxiang Lei, Wenbo Dai, Miaochang Liu, Huayue Wu, Ye Tao, Xiaobo Huang
Summary: The development of organic circularly polarized room temperature phosphorescence (CP-RTP) materials with tunable emission colors is a challenging issue. This study successfully constructs CP-RTP doped materials with green, yellow, and red afterglow by introducing chiral groups into three phosphors and using polyvinyl pyrrolidone as the host. The doped materials exhibit excitation-dependent and time-dependent RTP properties, providing an effective platform for constructing organic multicolor CP-RTP materials.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Physical
Jose Chavez, Luca Ceresa, Joseph Kimball, Emma Kitchner, Zygmunt Gryczynski, Ignacy Gryczynski
Summary: This study investigated the fluorescence/phosphorescence properties of 5-chloroindole embedded in poly (vinyl alcohol) films. The results showed that the fluorescence emission of 5-chloroindole was significantly quenched compared to indole, while the phosphorescence was twice as strong, indicating an increased intersystem crossing rate. Additionally, it was found that not only UV light but also longer wavelengths in the blue region could effectively populate the triplet state of 5-chloroindole and result in phosphorescence emission. This offers new possibilities for triplet state spectroscopy.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Zibin Zhang, Yu Yao, Lang He, Tao Hong, Shijun Li, Feihe Huang, Peter J. Stang
Summary: Coordination-driven self-assembly was utilized to construct two metallacycles using a dicarboxylate-functionalized dibenzo-18-crown-6 in combination with either a 0 degrees anthracene-based clip-type acceptor or a 60 degrees phenanthrene-based acceptor. The angularities of these components enabled the formation of a [2 + 2] rectangle and a [3 + 3] triangle, respectively. The synthesis, characterization, and host-guest chemistry of the two metallacycles were described and supported by 31P{1H}, 1H NMR spectra, and electrospray mass spectrometry. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Ming Li, Yang Liu, Li Shao, Bin Hua, Mengbin Wang, Haozhong Liang, Niveen M. Khashab, Jonathan L. Sessler, Feihe Huang
Summary: Variable stoichiometry co-crystals are important in solid-state supramolecular chemistry as they allow for the study of structure-property relationships and the synthesis of new scaffolds. In this work, the concept of variable stoichiometry co-crystals is extended to pillararene chemistry, resulting in the construction of a diverse set of supramolecular structures. These co-crystals display different physicochemical properties and can be used for vapochromic-based detection.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Haozhong Liang, Yuting Yang, Li Shao, Weijie Zhu, Xiaofeng Liu, Bin Hua, Feihe Huang
Summary: It is found that using pillar[5]arene (BrP5) as the macrocyclic host to encapsulate nonlinear optical (NLO) materials (OM, DAST, and MNS) can change their solid-state packing and manipulate their centrosymmetric arrangements, achieving second harmonic generation (SHG) in the solid and crystalline states. This research opens a new way to construct solid-state organic NLO materials with potential applications in high-power lasers, optical switches, and imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Polymer Science
Hui-Qing Peng, Wenping Zhu, Wu-Jie Guo, Qingyun Li, Shixiang Ma, Christophe Bucher, Bin Liu, Xiaofan Ji, Feihe Huang, Jonathan L. Sessler
Summary: Supramolecular polymers are self-assembled structures formed through noncovalent interactions, exhibiting reversibility, responsiveness, and stability. They have diverse applications in various fields. This review focuses on the determinants and driving forces of supramolecular polymer construction, highlighting the influence of different noncovalent interactions on their structure and function. Understanding these connections contributes to further advancements in this field.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xiaodan Xu, Rui Wang, Dongdong Li, Jiajia Xiang, Wei Zhang, Xueying Shi, Hongxia Xu, Shasha Yao, Jiwei Liu, Shiqun Shao, Zhuxian Zhou, Feihe Huang, Youqing Shen, Jianbin Tang
Summary: In this study, a pH-responsive polymer nanocarrier modified with aminoguanidine was developed for efficient delivery of bortezomib. The nanoparticles exhibited pH-responsive release in the acidic tumor microenvironment and induced immune activation and antigen uptake by dendritic cells. Consequently, they stimulated cytotoxic T lymphocyte infiltration and triggered robust antitumor immune responses, showing potent antitumor efficacy when combined with an immune checkpoint-blocking antibody.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Huaqiang Ju, Haoke Zhang, Li Xin Hou, Min Zuo, Miao Du, Feihe Huang, Qiang Zheng, Zi Liang Wu
Summary: We propose a facile strategy to achieve room-temperature phosphorescence in conventional hydrogels by polymerization-induced crystallization of dopant molecules, leading to clusterization-induced phosphorescence. Crown ethers dissolved in a concentrated acrylamide aqueous solution crystallize during polymerization to form large spherulites in the hydrogel, resulting in carbonyl clusters and phosphorescence emission. This strategy is universally applicable to hydrogels with different polymeric matrices and dopant molecules. The development of hydrogels with mechanical and phosphorescent properties holds great potential in the biomedical and engineering fields.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Huangtianzhi Zhu, Junkai Liu, Yitao Wu, Lei Wang, Haoke Zhang, Qi Li, Hu Wang, Hao Xing, Jonathan L. Sessler, Feihe Huang
Summary: In this study, a room-temperature phosphorescence (RTP) system responsive to alkyl halides was described. The system consisted of a meta-formylphenyl-bearing pillar[5]arene derivative that supported effective through-space charge transfer. Treatment with bromoethane enhanced the emission. An isomeric para-formylphenyl-bearing pillar[5]arene system proved ineffective in producing an RTP effect.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao, Yuan Ding, Weilin Wang
Summary: With the increasing demand for personalized medical care, supramolecular theranostic systems based on cyclodextrins (CDs) have become popular due to their reversible switchable structures, sensitive response to biological stimuli, and ability to integrate multiple capabilities in a programmable manner. This review focuses on the design of various functional modules and interactions in CD-based supramolecular systems for cancer diagnostics and therapeutics. By providing state-of-the-art examples, the review aims to enhance the understanding of the important role of cyclodextrin-based nanoplatforms in advancing supramolecular cancer theranostics.
Article
Chemistry, Multidisciplinary
Zuping Xiong, Jianyu Zhang, Lei Wang, Yuan Xie, Yipu Wang, Zujin Zhao, Haoke Zhang, Jing Zhi Sun, Feihe Huang, Ben Zhong Tang
Summary: Nonconjugated clusteroluminogens (CLgens), such as proteins and polystyrene, have become increasingly important in photophysics due to their advantages over traditional conjugated dyes in biological applications. However, their weak visible emissions in the aggregate state have hindered their development. This study proposes a strategy to construct a higher-level intramolecular through-space interaction (TSI) in multi-aryl-substituted alkanes, resulting in efficient clusteroluminescence (CL) with high luminescence quantum yield and long emission wavelength.
Article
Chemistry, Multidisciplinary
Yunxuan Feng, Shaolong Qi, Xinyang Yu, Xueyan Zhang, Huangtianzhi Zhu, Guocan Yu
Summary: Despite the breakthrough of immunotherapy, immune checkpoint inhibitors often have low response rate and resistance towards solid tumors. A hypoxic tumor microenvironment provides tumor cells with high concentrations of HIF-1 and polyamines to evade immune cell destruction. Reprogramming the immunogenic microenvironment has shown promising results in boosting immunotherapeutic performances.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Xuedong Xiao, Ding Xiao, Guan Sheng, Tianyu Shan, Jiao Wang, Xiaohe Miao, Yikuan Liu, Guangfeng Li, Yihan Zhu, Jonathan L. Sessler, Feihe Huang
Summary: The integration of mechanically interlocked molecules (MIMs) into purely organic crystalline materials has been achieved using a dative boron-nitrogen bond-driven self-assembly strategy, resulting in the preparation of polyrotaxane crystals. The polyrotaxane structure of the crystalline material was confirmed by single-crystal X-ray diffraction analysis and cryogenic high-resolution low-dose transmission electron microscopy. The polyrotaxane crystals exhibit enhanced softness and greater elasticity compared to nonrotaxane polymer controls, attributed to the synergistic microscopic motion of the rotaxane subunits. This work highlights the importance of integrating MIMs into crystalline materials.
Article
Chemistry, Multidisciplinary
Bohan Zhao, Jianwei Wang, Li Shao, Yitao Wu, Ming Li, Bin Hua, Feihe Huang
Summary: An efficient adsorptive separation method using nonporous adaptive crystals of perbromoethylated pillar[5]arene (BrP5) for monobromotoluene isomers is reported. The purity of separated m-bromotoluene from an equal volume mixture of m-bromotoluene and o-bromotoluene reaches 96.6% in one cycle, and the adsorbent BrP5 can be reused without losing separation performance.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Dan Wu, Jiaqi Lei, Zhankui Zhang, Feihe Huang, Marija Buljan, Guocan Yu
Summary: The synthesis of vital biomacromolecules through the polymerization of small biomolecules to support and multiply life is an emerging field that showcases the diversity and efficiency of chemistry as well as the flexibility and ingenuity of physiological environment. Efforts have been made to design and develop in situ intra/extracellular polymerization reactions, which have found applications in various important research areas, including cell surface engineering, biocompatible polymerization, cell behavior regulation, living cell imaging, targeted bacteriostasis, and precise tumor therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Haozhong Liang, Yuting Yang, Li Shao, Weijie Zhu, Xiaofeng Liu, Bin Hua, Feihe Huang
Summary: In this study, pillar[5]arene was used as a host molecule to encapsulate NLO molecules (OM, DAST, and MNS) in order to change their solid-state packing and manipulate their centrosymmetric arrangements. Experimental results showed that different packing arrangements resulted in different levels of second harmonic generation (SHG). This research provides a new approach to construct solid-state organic NLO materials with potential applications in high-power lasers, optical switches, and imaging.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
