期刊
CARBOHYDRATE POLYMERS
卷 131, 期 -, 页码 288-296出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.06.021
关键词
Homogalacturonan; Hippophae rhamnoides L.; Antitumor activity; Immunostimulating activity
资金
- National Natural Science Foundation of China [31300291]
- CAS Light of West China Program and Applying Basic Research Program of Qinghai province [2014-ZJ-751, 2015-ZJ-727]
Our previous study isolated an anti-fatigue polysaccharide (HRWP) from the Hippophae rhamnoides berry. In this study, using ion-exchange chromatography and gel filtration chromatography in turn, a watersoluble homogenous polysaccharide HRWP-A was isolated from HRWP. Structural analysis determined that HRWP-A was a polysaccharide with repeating units of (1 -> 4)-beta-D-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. An antitumor activity assay showed that HRWP-A could significantly inhibit the Lewis lung carcinoma (LLC) growth in tumor-bearing mice. Further experiments suggested that the antitumor effect of HRWP-A might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting NK cell activity and CTL cytotoxicity in tumor-bearing mice. To our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the H. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (C) 2015 Elsevier Ltd. All rights reserved.
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