Article
Biochemistry & Molecular Biology
Mahdi Golshan, Azadeh Hatef, Negar Kazori, Magdalena Socha, Miroslawa Sokolowska-Mikolajczyk, Hamid R. Habibi, Otomar Linhart, Sayyed Mohammad Hadi Alavi
Summary: This study reveals that exposure to bisphenol A (BPA) reduces sperm quality in goldfish and increases the levels of circulating LH and mRNA transcripts of upstream neuroendocrine regulators of reproduction.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Rafael Guerra Cintra, Rubens Wajnsztejn, Camila Martins Trevisan, Victor Zaia, Antonio Simone Lagana, Bianca Bianco, Erik Montagna
Summary: The study identified significantly higher blood Kisspeptin (KP) concentrations in girls with CPP compared to controls, with a positive correlation between KP concentration and patient age in the CPP group. Compared to PT patients, CPP patients had KP levels 36% higher, consistent with the predicted mechanisms and pathophysiology of CPP.
HORMONE RESEARCH IN PAEDIATRICS
(2021)
Review
Endocrinology & Metabolism
Saeed Masumi, Eun Bee Lee, Iman Dilower, Sameer Upadhyaya, V. Praveen Chakravarthi, Patrick E. Fields, M. A. Karim Rumi
Summary: Kisspeptins play an important role in regulating oocyte maturation by acting on the hypothalamic-pituitary-gonadal axis and directly on oocytes. Understanding the mechanisms of KP signaling can contribute to the development of novel assisted reproductive technologies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Obstetrics & Gynecology
Hitoshi Ozawa
Summary: Regulation of the reproductive system has long been understood through the actions of GnRH-LH/FSH and sex steroids, but the discovery of kisspeptin neurons and their role in communication with the HPG axis has shed new light on this process. Kisspeptin neurons are crucial in integrating internal and external environmental signals and transmitting them to the conventional HPG axis, ultimately influencing reproductive function through mechanisms that were previously not fully understood.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
R. Manoochehri, M. R. Jafarzadeh Shirazi, A. Akhlaghi, K. Tsutsui, M. R. Namavar, M. J. Zamiri, F. M. Rezazadeh
Summary: The study found that GnIH neurons play an important role in regulating reproductive events in British United Turkey hens, with prepubertal turkeys having a significantly higher abundance of GnIH neurons compared to pubertal and postpubertal turkeys.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Satoshi Ogawa, Priveena Nair Ramadasan, Rachel Anthonysamy, Ishwar S. Parhar
Summary: Substance P (SP) and neurokinin A (NKA) regulate reproductive hormone secretion in mammals via kisspeptin neurons, but their roles in non-mammalian vertebrates are not well understood. This study in zebrafish found male-dominant expression of Tac1 in specific brain regions, with associations between Tac1 and GnRH3 neurons but not with kiss2 neurons. Expression of the SP/NKA receptor tacr1a mRNA in brain regions containing GnRH3 or Kiss2 neurons suggests a potential direct action on male reproductive functions in zebrafish.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Rajae Talbi, Ferrari Kaitlin, Ji Hae Choi, Achi Gerutshang, Elizabeth A. McCarthy, Daniel Dischino, Silvia Leon, Victor M. Navarro
Summary: The interaction between NKB and dynorphin within arcuate Kiss1 neurons generates GnRH pulses, but these pulses still exist even in the absence of tachykinin signaling. In mice deficient in substance P, NKA, and NKB signaling, there is an increase in the frequency and amplitude of LH pulses. Administration of an NKB receptor agonist in intact male mice increases basal LH release without affecting its frequency, suggesting the existence of compensatory mechanisms in the generation of kisspeptin/GnRH pulses in these animals.
Article
Endocrinology & Metabolism
Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zolzaya Tumurgan, Aki Oride, Hiroe Okada, Satoru Kyo
Summary: AMH induces FSH beta-subunit expression in pituitary gonadotrophs while reducing Kiss-1 and Kiss-1R gene expression. It inhibits kisspeptin-induced gonadotropin subunit expression, but does not affect GnRH-induced expression.
Article
Endocrinology & Metabolism
Michael J. Kreisman, Kirollos S. Tadrousse, Richard B. McCosh, Kellie M. Breen
Summary: These studies demonstrate that chronic undernutrition disrupts ovarian cyclicity in females by impairing both ARC(Kiss1) control of LH pulses and AVPV(Kiss1) induction of the LH surge.
Article
Andrology
Maleeha Akram, Syed Raza Rizvi, Mazhar Qayyum, David J. Handelsman
Summary: Puberty is a critical biological process that marks the completion of sexual maturation and attainment of full reproductive capability. The timing of puberty is influenced by genetic factors and various internal and external factors. Although the exact mechanism of pubertal onset is not fully understood, it involves complex signaling pathways of the hypothalamo-pituitary-testicular (HPT) axis. This review presents a classification of 598 genes involved in HPT axis development and identifies 75 genes with reported genetic mutations that can delay or disrupt male puberty.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Endocrinology & Metabolism
Aki Oride, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Hiroe Okada, Satoru Kyo
Summary: This study found that AMH plays a crucial role in controlling the hypothalamic-pituitary-gonadal axis by stimulating GnRH expression. Additionally, AMH may act as a potent repressor of Kiss-1 gene expression induced by KP10.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Sasha R. Howard
Summary: Puberty is a transition from childhood to adult reproductive capacity, governed by the reactivation of the hypothalamic-pituitary-gonadal axis. This leads to flux in reproductive hormones during adolescence, making diagnosis and management of precocious, delayed, or disordered puberty challenging.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
D. Franssen, A. Barroso, F. Ruiz-Pino, M. J. Vazquez, D. Garcia-Galiano, J. M. Castellano, R. Onieva, M. Ruiz-Cruz, M. Poutanen, F. Gaytan, C. Dieguez, L. Pinilla, M. Lopez, J. Roa, M. Tena-Sempere
Summary: Reproduction is closely linked to energy and metabolic status, with AMPK signaling in GnRH neurons playing a crucial role in metabolic control of the female reproductive axis, particularly during puberty and negative energy balance.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Endocrinology & Metabolism
Karen J. Tonsfeldt, Pamela L. Mellon, Hanne M. Hoffmann
Summary: Life on Earth evolved under the pattern of light and darkness. Organisms developed self-sustaining biological clocks aligned with the 24-hour rhythm of the Earth. Disruption of circadian rhythms can negatively impact fertility. This review summarizes the neuronal networks underlying circadian rhythms and the luteinizing hormone surge.
Article
Multidisciplinary Sciences
Luciano Cardoso Santos, Jeane Martinha dos Anjos Cordeiro, Larissa da Silva Santana, Erikles Macedo Barbosa, Bianca Reis Santos, Leticia Dias Mendonca, Maria Clara da Silva Galro Cunha, William Morais Machado, Larissa Rodrigues Santana, Maira Guimares Kersul, Patricia Costa Henriques, Roberta Araujo Lopes, Paola Pereira das Neves Snoeck, Raphael Escorsim Szawka, Juneo Freitas Silva
Summary: This study evaluated the potential of Kp10 to restore gonadal function in hypothyroid male rats. The authors found that hypothyroidism negatively affected testicular and sex gland mass, as well as sperm morphology, motility, and vigor. Kp10 treatment was able to reverse these effects, improving gonadal function and sperm quality in hypothyroid rats.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Zafer Sahin, Mete Ozcan, Ahmet Ozkaya, Sinan Canpolat, Selim Kutlu, Haluk Kelestimur
Summary: This study found that long-term administration of kisspeptin can affect the fatty acid profile, body weight, and adipose tissue in rats. The kisspeptin group had lower percentages of saturated and monounsaturated fatty acids in serum, while the P234 group had lower saturated fatty acids and higher unsaturated fatty acids in adipose tissue. Moreover, kisspeptin injection resulted in decreased body weight.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Munevver Gizem Hekim, Muhammed Mirac Kelestemur, Funda Gulcu Bulmus, Batuhan Bilgin, Ferah Bulut, Ebru Gokdere, Mehmet Ridvan Ozdede, Haluk Kelestimur, Sinan Canpolat, Mete Ozcan
Summary: Asprosin may affect levels of blood glucose, irisin, ghrelin, leptin, as well as triglycerides, cholesterol, and low-density lipoprotein in the liver. The study found that asprosin increased blood glucose levels in healthy animals but did not change blood glucose levels in diabetic animals. Additionally, asprosin decreased irisin levels and increased ghrelin levels in diabetic mice, but did not change leptin levels. Moreover, asprosin decreased levels of triglycerides, cholesterol, and low-density lipoprotein in the liver of diabetic mice.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Sibel Ozcan, Muhammed Mirac Kelestemur, Munevver Gizem Hekim, Ozgur Bulmus, Ferah Bulut, Batuhan Bilgin, Sinan Canpolat, Mete Ozcan
Summary: Recent studies have shown a strong link between adipokines and neuropathic pain, with particular interest in the effects of a novel adipokine, asprosin. In mouse models of neuropathic pain with metabolic, toxic, and traumatic etiologies, asprosin demonstrated significant antihypersensitivity effects on both mechanical and thermal hypersensitivity. Furthermore, asprosin did not affect motor activity in mice, suggesting its potential as a clinical treatment for chronic pain associated with peripheral injuries and diseases.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Ahmet Yardimci, Nazife Ulker, Ozgur Bulmus, Elif Sahin, Ahmet Alver, Ibrahim Halil Gungor, Gaffari Turk, Gokhan Artas, Nalan Kaya Tektemur, Mete Ozcan, Haluk Kelestimur, Sinan Canpolat
Summary: The study suggests that irisin can improve reproductive dysfunction in obese male rats induced by a high-fat diet, including improving erectile function, sperm quality, and reducing testicular damage caused by fat.
NEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Omer Faruk Kalkan, Osman Aktas, Yunus Emre Surmeneli, Ahmet Alver, Mete Ozcan, Zafer Sahin
Summary: This study aimed to investigate the role of irisin in the neuroprotective process of exercise training in diabetic rats. It was found that irisin may have a role in the neuroprotective effect of exercise training.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Meeting Abstract
Physiology
B. Bilgin, M. G. Ersoz, F. Bulut, M. M. Kelestemur, M. Adam, S. Canpolat, M. Ozcan
Meeting Abstract
Physiology
F. Bulut, B. Bilgin, M. G. Hekim, M. M. Kelestemur, M. Adam, A. Ozgen, M. Ozcan
