Impact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise

Exercise medicine for cancer cachexia: targeted exercise to counteract mechanisms and treatment side effects

(2022) Georgios Mavropalias et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A systematic review examining the relationship between cytokines and cachexia in incurable cancer

(2022) D. Robert Paval et al.   Journal of Cachexia Sarcopenia and Muscle

Exercise in People With Cancer: A Spotlight on Energy Regulation and Cachexia

(2022) Jessica Allan et al.   Frontiers in Physiology

Voluntary exercise does not improve muscular properties or functional capacity during C26-induced cancer cachexia in mice

(2021) Charlotte Hiroux et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

High-intensity interval training or resistance training versus usual care in men with prostate cancer on active surveillance: A three-arm feasibility randomized controlled trial

(2021) Efthymios Papadopoulos et al.   Applied Physiology Nutrition and Metabolism

Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?

(2021) Peter R.T. Bowman et al.   PeerJ

A Systematic Review of the Safety, Feasibility and Benefits of Exercise for Patients with Advanced Cancer

(2021) Nico De Lazzari et al.   Cancers

Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle

(2020) Rachel L. Nosacka et al.   Journal of Cachexia Sarcopenia and Muscle

Repeated eccentric contractions positively regulate muscle oxidative metabolism and protein synthesis during cancer cachexia in mice

(2020) Justin P. Hardee et al.   JOURNAL OF APPLIED PHYSIOLOGY

Management of Cancer Cachexia: ASCO Guideline

(2020) Eric J. Roeland et al.   JOURNAL OF CLINICAL ONCOLOGY

Fatigue, barriers to physical activity and predictors for motivation to exercise in advanced Cancer patients

(2020) J. Frikkel et al.   BMC Palliative Care

A Cross-Sectional Study Evaluating the Effects of Resistance Exercise on Inflammation and Neurotrophic Factors in Elderly Women with Obesity

(2020) Hee-Tae Roh et al.   Journal of Clinical Medicine

Exercise and GLUT4

(2020) Marcelo Flores-Opazo et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Exercise and colorectal cancer: a systematic review and meta-analysis of exercise safety, feasibility and effectiveness

(2020) Benjamin Singh et al.   International Journal of Behavioral Nutrition and Physical Activity

Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia

(2020) Megan E. Rosa-Caldwell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders

(2020) Yasuo Kitajima et al.   Journal of Physiological Sciences

Pharmacological targeting of mitochondrial function and reactive oxygen species production prevents colon 26 cancer-induced cardiorespiratory muscle weakness

(2020) Ashley J. Smuder et al.   Oncotarget

Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy

(2020) Tadashi Yoshida et al.   Cells

Nutraceuticals and Exercise against Muscle Wasting during Cancer Cachexia

(2020) Giorgio Aquila et al.   Cells

High-intensity interval training is more effective than continuous training to reduce inflammation markers in female rats with cisplatin nephrotoxicity

(2020) Allyne Baía Leite et al.   LIFE SCIENCES

Moderate Exercise Improves Experimental Cancer Cachexia by Modulating the Redox Homeostasis

(2019) Riccardo Ballarò et al.   Cancers

Eccentric Muscle Contractions: Risks and Benefits

(2019) Stéphanie Hody et al.   Frontiers in Physiology

Modeling Human Cancer-induced Cachexia

(2019) Erin E. Talbert et al.   Cell Reports

Metastasis and cachexia: alongside in clinics, but not so in animal models

(2019) Rebeka Tomasin et al.   Journal of Cachexia Sarcopenia and Muscle

Exercise training, circulating cytokine levels and immune function in cancer survivors: A meta-analysis

(2019) Nasim Khosravi et al.   BRAIN BEHAVIOR AND IMMUNITY

American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control

(2019) ALPA V. PATEL et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Mitochondrial uncoupling, ROS generation and cardioprotection

(2018) Susana Cadenas   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Effects of the beta 2 agonist formoterol on atrophy signaling, autophagy, and muscle phenotype in respiratory and limb muscles of rats with cancer-induced cachexia

(2018) Anna Salazar-Degracia et al.   BIOCHIMIE

Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia

(2018) Parash Parajuli et al.   DEVELOPMENTAL CELL

Relationship between TNF-α −1031T/C gene polymorphism, plasma level of TNF-α, and risk of cachexia in head and neck cancer patients

(2018) Tomasz Powrózek et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice

(2018) Daisuke Tatebayashi et al.   PLoS One

Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients

(2018) Erin E. Talbert et al.   Journal of Cachexia Sarcopenia and Muscle

Pancreatic Cancer–Induced Cachexia and Relevant Mouse Models

(2018) Sally E. Henderson et al.   PANCREAS

Eccentric Training Improves Body Composition by Inducing Mechanical and Metabolic Adaptations: A Promising Approach for Overweight and Obese Individuals

(2018) Valérie Julian et al.   Frontiers in Physiology

Cancer cachexia impairs neural respiratory drive in hypoxia but not hypercapnia

(2018) Daryl P. Fields et al.   Journal of Cachexia Sarcopenia and Muscle

Disrupted Skeletal Muscle Mitochondrial Dynamics, Mitophagy, and Biogenesis during Cancer Cachexia: A Role for Inflammation

(2017) Brandon N. VanderVeen et al.   Oxidative Medicine and Cellular Longevity

Orthotopic Patient-Derived Pancreatic Cancer Xenografts Engraft Into the Pancreatic Parenchyma, Metastasize, and Induce Muscle Wasting to Recapitulate the Human Disease

(2017) Kristina L. Go et al.   PANCREAS

Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways

(2017) Guohua Zhang et al.   Scientific Reports

Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation

(2017) Huibin Tang et al.   Scientific Reports

Eccentric versus traditional resistance exercise for older adult fallers in the community: a randomized trial within a multi-component fall reduction program

(2017) Paul LaStayo et al.   BMC Geriatrics

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice

(2017) Jacob L. Brown et al.   Journal of Cachexia Sarcopenia and Muscle

Skeletal Muscle Remodeling in Response to Eccentric vs. Concentric Loading: Morphological, Molecular, and Metabolic Adaptations

(2017) Martino V. Franchi et al.   Frontiers in Physiology

Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle

(2017) Zhe Song et al.   Scientific Reports

Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice

(2016) Ira J. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?

(2016) Tara C. Mueller et al.   BMC CANCER

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

(2016) Line Pedersen et al.   Cell Metabolism

From inflammation to cancer

(2016) A. Korniluk et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Eccentric contraction-induced myofiber growth in tumor-bearing mice

(2016) Justin P. Hardee et al.   JOURNAL OF APPLIED PHYSIOLOGY

Aerobic and resistance training dependent skeletal muscle plasticity in the colon-26 murine model of cancer cachexia

(2016) Andy V. Khamoui et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities

(2016) Erin E. Talbert et al.   MOLECULAR CANCER THERAPEUTICS

Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation

(2016) Stefan Matecki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia

(2016) Daniel Delitto et al.   Oncotarget

Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo

(2016) Firouzeh Dehghan et al.   Scientific Reports

Dysfunction of respiratory muscles in critically ill patients on the intensive care unit

(2016) David Berger et al.   Journal of Cachexia Sarcopenia and Muscle

Moderate Load Eccentric Exercise; A Distinct Novel Training Modality

(2016) Hans Hoppeler   Frontiers in Physiology

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

(2016) Andrea Bonetto et al.   Jove-Journal of Visualized Experiments

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

(2016) Marco Demaria et al.   Aging-US

Correlation Between the International Consensus Definition of the Cancer Anorexia-Cachexia Syndrome (CACS) and Patient-Centered Outcomes in Advanced Non-Small Cell Lung Cancer

(2015) Thomas W. LeBlanc et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

The complex liaison between cachexia and tumor burden (Review)

(2015) ANDREA DE LERMA BARBARO   ONCOLOGY REPORTS

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

(2015) Surendra K. Shukla et al.   Oncotarget

Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients

(2015) Lorena Lerner et al.   Journal of Cachexia Sarcopenia and Muscle

Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training

(2015) T. Scott Bowen et al.   Journal of Cachexia Sarcopenia and Muscle

TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia

(2015) Stephanie H. Greco et al.   PLoS One

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

(2014) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pharmacological Strategies in Lung Cancer-Induced Cachexia: Effects on Muscle Proteolysis, Autophagy, Structure, and Weakness

(2014) Alba Chacon-Cabrera et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Modeling human cancer cachexia in colon 26 tumor-bearing adult mice

(2014) Erin E. Talbert et al.   Journal of Cachexia Sarcopenia and Muscle

New horizons in the pathogenesis, diagnosis and management of sarcopenia

(2013) A. A. Sayer et al.   AGE AND AGEING

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2013) David Moher   ANNALS OF INTERNAL MEDICINE

Cancer cachexia decreases specific force and accelerates fatigue in limb muscle

(2013) B.M. Roberts et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signaling pathways controlling skeletal muscle mass

(2013) Marc A. Egerman et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice

(2013) Clara Fermoselle et al.   EXPERIMENTAL PHYSIOLOGY

Diaphragm and ventilatory dysfunction during cancer cachexia

(2013) Brandon M. Roberts et al.   FASEB JOURNAL

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia

(2013) Melissa J. Puppa et al.   FASEB JOURNAL

Muscle wasting in cancer

(2013) N. Johns et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of the renin-angiotensin system improves physiological outcomes in mice with mild or severe cancer cachexia

(2013) Kate T. Murphy et al.   INTERNATIONAL JOURNAL OF CANCER

Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model

(2013) A. ARIA TZIKA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Eccentric exercise in rehabilitation: safety, feasibility, and application

(2013) Paul LaStayo et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index

(2013) Lisa Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Smad3 Induces Atrogin-1, Inhibits mTOR and Protein Synthesis, and Promotes Muscle Atrophy In Vivo

(2013) Craig A. Goodman et al.   MOLECULAR ENDOCRINOLOGY

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Exercise Training Prevents TNF-α Induced Loss of Force in the Diaphragm of Mice

(2013) Norman Mangner et al.   PLoS One

Eccentric Exercise Training: Modalities, Applications and Perspectives

(2013) Marie-Eve Isner-Horobeti et al.   SPORTS MEDICINE

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

(2012) Andrea Bonetto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

NF-κB Activation Is Required for the Transition of Pulmonary Inflammation to Muscle Atrophy

(2012) Ramon C. J. Langen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats

(2012) F.F. Donatto et al.   CYTOKINE

Does Exercise-Induced Muscle Damage Play a Role in Skeletal Muscle Hypertrophy?

(2012) Brad J. Schoenfeld   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Increase in Muscle Mitochondrial Biogenesis Does Not Prevent Muscle Loss but Increased Tumor Size in a Mouse Model of Acute Cancer-Induced Cachexia

(2012) Xiao Wang et al.   PLoS One

Cancer cachexia prevention via physical exercise: molecular mechanisms

(2012) Douglas W. Gould et al.   Journal of Cachexia Sarcopenia and Muscle

Respiratory diseases and muscle dysfunction

(2012) Joaquim Gea et al.   Expert Review of Respiratory Medicine

IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

(2012) James P White et al.   Skeletal Muscle

Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice

(2011) Kate T. Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The SCF-Fbxo40 Complex Induces IRS1 Ubiquitination in Skeletal Muscle, Limiting IGF1 Signaling

(2011) Jun Shi et al.   DEVELOPMENTAL CELL

Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

(2011) Leslie M. Baehr et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training

(2011) B. Hoier et al.   JOURNAL OF PHYSIOLOGY-LONDON

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer

(2011) Lee W. Jones et al.   LUNG CANCER

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

(2011) Andrea Bonetto et al.   PLoS One

Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise

(2011) Fabio Penna et al.   Journal of Cachexia Sarcopenia and Muscle

Muscle Wasting in Cancer Cachexia: Clinical Implications, Diagnosis, and Emerging Treatment Strategies

(2010) Shontelle Dodson et al.   Annual Review of Medicine

Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse

(2010) Paola Aulino et al.   BMC CANCER

The TWEAK–Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice

(2010) Ashwani Mittal et al.   JOURNAL OF CELL BIOLOGY

The Mechanisms of Muscle Hypertrophy and Their Application to Resistance Training

(2010) Brad J Schoenfeld   JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial

(2010) Ida C Helmark et al.   ARTHRITIS RESEARCH & THERAPY

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pancreatic cancerrelated cachexia: influence on metabolism and correlation to weight loss and pulmonary function

(2009) Jeannine Bachmann et al.   BMC CANCER

Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment

(2009) C. M.M. Prado et al.   CLINICAL CANCER RESEARCH

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Airway Clearance in Duchenne Muscular Dystrophy

(2009) Richard M. Kravitz   PEDIATRICS

Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

(2009) Nava Bashan et al.   PHYSIOLOGICAL REVIEWS

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Morphology, metabolism, microcirculation, and strength of skeletal muscles in cancer-related cachexia

(2008) Marc-André Weber et al.   ACTA ONCOLOGICA

Effect of endurance training upon lipid metabolism in the liver of cachectic tumour-bearing rats

(2008) F. S. Lira et al.   CELL BIOCHEMISTRY AND FUNCTION

Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

(2008) Antonio L. Serrano et al.   Cell Metabolism

The initiation factor eIF3-f is a major target for Atrogin1/MAFbx function in skeletal muscle atrophy

(2008) Julie Lagirand-Cantaloube et al.   EMBO JOURNAL

Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study

(2008) Carla MM Prado et al.   LANCET ONCOLOGY

Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production

(2008) Scott K. Powers et al.   PHYSIOLOGICAL REVIEWS

Interleukin-6 and cachexia in ApcMin/+ mice

(2007) Kristen A. Baltgalvis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training

(2007) Mari-Carmen Gomez-Cabrera et al.   FREE RADICAL BIOLOGY AND MEDICINE

Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans

(2007) Kirsten A. Burgomaster et al.   JOURNAL OF PHYSIOLOGY-LONDON

Symptoms limiting activity in cancer patients with breathlessness on exertion: ask about muscle fatigue

(2007) A Wilcock et al.   THORAX