Article
Engineering, Biomedical
Yi Liu, Chui-Wei Wong, Shu-Wei Chang, Shan-hui Hsu
Summary: This study presents a phenol-functionalized chitosan self-healing hydrogel for injectable or printable tissue constructs. The hydrogel demonstrates fast gelling rate, good self-healing ability, and easy printability, which can be reinforced by secondary visible light crosslinking.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Chengkun Liu, Chang Liu, Zhiyuan Liu, Zhuang Shi, Shihai Liu, Xiaojuan Wang, Xiaoqiang Wang, Fang Huang
Summary: A thermogelling chitosan/glycerophosphate formulation was developed by incorporating dihydrocaffeic acid (DHCA), which significantly enhanced gel-forming capacity and tissue adherence. The thermosensitive hydrogels showed improved hemostasis and reduced blood loss in both in vitro and in vivo models. The results demonstrated the potential of enhancing thermogelling and bioadhesion of chitosan-based hydrogels through noncovalent supramolecular mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Medicinal
Lavanya Mude, Bharat Kumar Reddy Sanapalli, Anoop Narayanan, Sachin Kumar Singh, Veera Venkata Satyanarayana Reddy Karri
Summary: Diabetic wound is a devastating complication of diabetes, with limited treatment options and poor outcomes.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Materials Science, Paper & Wood
Bo-Nan Jiang, Dan Li, Xue-Na Zou, Hui-Ge Wei, Cheng Zhong, Li-Qiang Chu
Summary: Biopolymer-based injectable hydrogels with antibacterial activity have great potential for biomedical applications. In this study, a double network hydrogel was successfully prepared, which exhibited excellent injectability and antibacterial activity.
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zhouying Tan, Xi Li, Chaojie Yu, Mengmeng Yao, Zhongming Zhao, Bingyan Guo, Lei Liang, Yuping Wei, Fanglian Yao, Hong Zhang, Junjie Li
Summary: A self-gelling hemostasis powder based on polyacrylic acid/polyacrylamide/quaternate chitosan (PAA/PAM/QCS) is prepared to improve the hemostatic effect of non-compressible wounds, unknown bleeding points, and irregularly shaped wounds. The PAA/PAM/QCS rapidly forms a stable hydrogel when in contact with water and shows good adhesive properties on wet tissue surfaces. The introduction of QCS enhances the antibacterial activity of the self-gelling hemostasis powder.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Flavio Silva de Souza, Ivana Lourenco de Mello Ferreira, Marcos Antonio da Silva Costa, Marcia Parente Melo da Costa, Gustavo Monteiro da Silva
Summary: This study prepared superabsorbent hydrogels made of high acyl gellan without crosslinkers. It was found that variations in pH and gellan solution concentration affected the physical properties and morphology of the hydrogels.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Shangzhi Li, Zhiqiang Ke, Xiaotong Peng, Penghui Fan, Jiayi Chao, Ping Wu, Pu Xiao, Yingshan Zhou
Summary: This research developed an injectable self-healing hyaluronic acid-based hydrogel that exhibits fast gelation and excellent self-healing capability, making it a potential candidate for nerve repair.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Feipeng Wu, Hongxia Zhao, Jiahui Shi, Lang Long, Zhiqiang Yang, Hua Jin, Xuedan Hou
Summary: Curcumin is an active ingredient with multiple pharmacological effects. An injectable curcumin loaded chitosan/hydroxyapatite bone cement was prepared, demonstrating improved solubility and drug release properties. The material showed significant inhibitory effects on MG63 cells.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Engineering, Environmental
Meiyue Wang, Sen Lin, Mengzhe Liu, Jing Jiao, Hongyan Mi, Jingjing Sun, Yiming Liu, Ruiying Guo, Sirui Liu, Haojie Fu, Yanyu Yang, Rui Li
Summary: By reacting carboxymethyl chitosan (CMC) with dialdehyde-functionalized polyethylene glycol (DF-PEG), an injectable and biocompatible hydrogel was developed. The hydrogel demonstrated wet tissue adhesion, self-healing, and rapid degradation within one week. It acted as a physical barrier to prevent adhesion by covering irregular wounds and fixing to targeted tissues. In a cecum-sidewall abrasion model, the hydrogel significantly reduced the severity of peritoneal adhesion by balancing the extracellular matrix, fibrinolytic system, and inhibiting inflammatory responses. The CMC/DF-PEG hydrogel holds promise as a solution for postoperative antiadhesion in surgery.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Marine & Freshwater Biology
Rui Chen, Yanan Hao, Secundo Francesco, Xiangzhao Mao, Wen-Can Huang
Summary: A double-cross-linking chitosan-based hydrogel with antibacterial, self-healing, and injectable properties is reported. The hydrogel is formed by the coordination of thiolated chitosan with silver-sulfur (Ag-S) and the covalent cross-linking of thiolated chitosan with genipin. The hydrogel exhibits long-lasting antibacterial activity and has excellent biocompatibility and biodegradability.
MARINE LIFE SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Applied
Jeong Wook Seo, Su Ryon Shin, Min-Young Lee, Jae Min Cha, Kyung Hyun Min, Sang Cheon Lee, Seon Young Shin, Hojae Bae
Summary: The newly developed HBC-MA hydrogel possesses thermo-sensitive and photo-crosslinkable properties, preventing unintended loss of the graft after subcutaneous injection in mice and significantly improving mechanical strength and stability of the graft with visible light applied beneath the skin.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Yajie Zhong, Farzad Seidi, Yilin Wang, Ling Zheng, Yongcan Jin, Huining Xiao
Summary: An injectable self-healing hydrogel with inherent antibacterial activity was developed by forming dynamic covalent bonds between boronic acid and catechol groups in quaternized chitosan, along with encapsulating EGCG. The hydrogels showed excellent dual functions of antibacterial and antioxidant properties, and demonstrated good biocompatibility and contact-active antibacterial activity. In vivo evaluation showed the hydrogels' regenerative wound healing performance, highlighting their potential as novel wound dressings for wound management.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Lin Huang, Wantao Wang, Yiwen Xian, Lei Liu, Jinghao Fan, Hongmei Liu, Zhaomin Zheng, Decheng Wu
Summary: This study reported a rapidly forming injectable chitosan/PEG hydrogel (CSMA-PEGDA-L) that can retard the progression of intervertebral disc (IVD) degeneration. The hydrogel demonstrated strong compressive strength and low cytotoxicity. When implanted on the punctured IVD of rats, it effectively slowed down the degenerative changes.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Applied
Fereshteh Kazemi-Aghdam, Vahid Jahed, Maryam Dehghan-Niri, Fariba Ganji, Ebrahim Vasheghani-Farahani
Summary: The study developed an injectable chitosan hydrogel with enhanced mechanical strength and osteoinductivity by synthesizing chitosan-modified halloysite nanotubes and loading bone inducer. The resulting scaffold showed improved biocompatibility and promoted proliferation and differentiation of bone cells, making it a promising candidate for bone regeneration.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)