Article
Medicine, General & Internal
Susanne Stampf, Nicolas J. Mueller, Christian van Delden, Manuel Pascual, Oriol Manuel, Vanessa Banz, Isabelle Binet, Sabina De Geest, Pierre-Yves Bochud, Alexander Leichtle, Stefan Schaub, Jurg Steiger, Michael Koller
Summary: The STCS is a large transplant cohort study that has enrolled over 5500 solid organ transplant recipients by the end of 2019. The study has published approximately 70 scientific papers and plans to further explore personalized medicine and digital epidemiology in the future.
Article
Medicine, General & Internal
McKaylee M. Robertson, Sarah Gorrell Kulkarni, Madhura Rane, Shivani Kochhar, Amanda Berry, Mindy Chang, Chloe Mirzayi, William You, Andrew Maroko, Rebecca Zimba, Drew Westmoreland, Christian Grov, Angela Marie Parcesepe, Levi Waldron, Denis Nash
Summary: The CHASING COVID Cohort Study is a community-based prospective study in the USA, aiming to evaluate the impact of SARS-CoV-2 infection and the pandemic on psychosocial and economic outcomes. With 6740 participants enrolled, the study has conducted various assessments and research evaluations.
Article
Medicine, General & Internal
Lu Wang, Dongjie Xie, Jingrong Yu, Mark Momoh Koroma, Mengsi Qiu, Wentao Duan, Xu-Fu Zhang, Ying-Chun Dai
Summary: This study aims to investigate the seroprevalence and seroincidence of noroviruses in a cohort from northern China. It will evaluate the immune responses against different norovirus genotypes and analyze the associations between genotype blockade antibodies, sociodemographic factors, and human histo-blood group antigens. The study will provide insight into the mechanism driving the replacement of norovirus genotypes and the role of herd immunity in new emerging or re-emerging variants.
Article
Medicine, General & Internal
Alyssa Chan-Cuzydlo, Dustin J. Harrison, Brian L. Pike, Bart J. Currie, Mark Mayo, Mark G. Salvador, William R. Hulsey, Joseph Azzarello, Jeffrey Ellis, Daniel Kim, William King-Lewis, Jessica Nicole Smith, Barbara Rodriguez, Ryan C. Maves, James Lawler, Kevin L. Schully
Summary: The study describes a cohort of US Marines and Sailors who participated in joint training exercises in Australia between 2016-2020. The participants were predominantly white males under 24 years old, with most being junior enlisted and non-commissioned officers, particularly from infantry occupational specialties. Future plans include screening for various infectious diseases endemic in Australia and characterizing immune responses in the participants.
Article
Medicine, General & Internal
Elie Mulhem, Andrew Oleszkowicz, David Lick
Summary: This study in Southeast Michigan found that older age, male gender, certain chronic diseases, and use of specific medications were associated with higher in-hospital mortality among COVID-19 patients. As experience in treating the disease increased, the in-hospital mortality rate decreased. Black patients were more likely to be hospitalized and receive mechanical ventilation, but less likely to die in the hospital compared to white patients.
Article
Medicine, General & Internal
Sana M. Khan, Leslie Farland, Collin J. Catalfamo, Erika Austhof, Melanie L. Bell, Zhao Chen, Felina Cordova-Marks, Kacey C. Ernst, Pamela Garcia-Filion, Kelly M. Heslin, Joshua Hoskinson, Megan L. Jehn, Emily C. S. Joseph, Connor P. Kelley, Yann Klimentidis, Stephanie Russo Carroll, Lindsay N. Kohler, Kristen Pogreba-Brown, Elizabeth T. Jacobs
Summary: This study aimed to compare the symptoms of laboratory-confirmed COVID-19 cases with laboratory-confirmed negative individuals and untested individuals who reported symptoms within a large prospective cohort study.
Article
Immunology
Chih-Chung Chen, Yao-Min Hung, Lu-Ting Chiu, Mei-Chia Chou, Renin Chang, James Cheng-Chung Wei
Summary: This study found that symptomatic leptospirosis is associated with an increased risk of subsequent major autoimmune diseases, especially in severe cases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Lauren D'Mello-Guyett, Oliver Cumming, Sharla Bonneville, Rob D'hondt, Maria Mashako, Brunette Nakoka, Alexandre Gorski, Dorien Verheyen, Rafael van den Bergh, Placide Okitayemba Welo, Peter Maes, Francesco Checchi
Summary: The study showed that a hygiene kit intervention among case-households may effectively reduce cholera transmission among household contacts and environmental contamination within the household. However, there was no significant effect on self-reported diarrhoea or food contamination. Further research is needed to evaluate the potential use of proactive localized distribution in future cholera response programs.
Article
Immunology
Yuwei Sun, Eric Kim, Christina L. Kong, Benjamin F. Arnold, Travis C. Porco, Nisha R. Acharya
Summary: This study evaluated the effectiveness of the recombinant zoster vaccine in preventing herpes zoster in a real-world setting and found that its effectiveness remains high outside of a clinical trial setting, suggesting that it can effectively prevent herpes zoster.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Lucy O. Attwood, Mellissa Bryant, Sue J. Lee, Olga Vujovic, Peter Higgs, Joseph S. Doyle, Andrew J. Stewardson
Summary: This study aims to describe the burden, clinical spectrum, management and outcomes of invasive infections in people who inject drugs (PWID), as well as determine the impact of current care models on treatment completion and post-discharge outcomes. It is a prospective multicentre cohort study conducted in Australian public hospitals, collecting data through medical records and patient interviews. Importance rating: 8/10.
Article
Medicine, General & Internal
Nicholas M. Mohr, Ian D. Plumb, Kari K. Harland, Tamara Pilishvili, Katherine E. Fleming-Dutra, Anusha Krishnadasan, Karin F. Hoth, Sharon H. Saydah, Zachary Mankoff, John P. Haran, Melissa Briggs-Hagen, Eliezer Santos Leon, David A. Talan, Project PREVENT Network
Summary: This study aimed to investigate the impact of COVID-19 vaccination on prolonged symptoms following COVID-19. The results showed that healthcare personnel who received COVID-19 vaccination had a lower prevalence of symptoms at 6 weeks after illness onset compared to those who were unvaccinated, and they were able to return to work earlier.
Article
Medicine, General & Internal
Samuel Videholm, Urban Kostenniemi, Torbjorn Lind, Sven-Arne Silfverdal
Summary: Preterm birth and other perinatal factors are associated with an increased risk of severe infections in young children. Therefore, clinical guidelines for assessing infection risks in young children should take perinatal factors into consideration.
Article
Medicine, General & Internal
Jacek Skarbinski, Liyan Liu, Vennis Hong, Laura B. Amsden, Bruce H. Fireman, Vincent M. Yau, Devin Incerti, Lei Qian, Heidi Fischer, Bradley K. Ackerson, Sally F. Shaw, Sara Y. Tartof
Summary: This retrospective cohort study assessed the association between tocilizumab administration and clinical outcomes among mechanically ventilated patients with COVID-19 pneumonia. The results showed that, compared with patients not treated with tocilizumab, patients treated with tocilizumab had a similar risk of death within the 28-day follow-up period, but had a significantly longer time-to-extubation and time-to-hospital-discharge.
Article
Immunology
Sarah Stabler, Jonathan Giovannelli, David Launay, Angelique Cotteau-Leroy, Marion Heusele, Guillaume Lefevre, Louis Terriou, Marc Lambert, Sylvain Dubucquoi, Eric Hachulla, Vincent Sobanski
Summary: This study found that the incidence of serious infectious events (SIEs) in patients with autoimmune disease (AID) treated with RTX was 17.3 and 11.3 per 100 person-years at 1 and 2 years, respectively. The main SIEs observed were pneumonia and bacteremia, and identified risk factors included age, history of diabetes, history of cancer, concomitant steroid treatment, and low CD4 lymphocyte count at RTX initiation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jefree Johari, Robert D. Hontz, Brian L. Pike, Tupur Husain, Chee-Kheong Chong, Norhayati Rusli, Lokman-Hakim Sulaiman, Khebir Verasahib, Rozainanee Mohd Zain, Adzzie-Shazleen Azman, Chee Sieng Khor, Siti-Sarah Nor'e, Vunjia Tiong, Hai Yen Lee, Boon-Teong Teoh, Sing Sin Sam, Jing-Jing Khoo, Juraina Abd Jamil, Shih-Keng Loong, Che Norainon Yaacob, Nur-Hidayana Mahfodz, Noor Syahida Azizan, Nurul Asma Anati Che Mat Seri, Nurul-Farhana Mohd-Rahim, Habibi Hassan, Hasmawati Yahaya, Jose A. Garcia-Rivera, Sazaly AbuBakar
Summary: MERS-CoV is a viral respiratory infection first reported in Saudi Arabia in 2012. The ongoing study MERCURIAL aims to provide evidence of MERS-CoV seroconversion among Malaysian Hajj pilgrims over several years. Data on demographics, medical conditions, symptoms experienced during pilgrimage, and exposure to camels are collected and analyzed to better understand the threat of MERS-CoV spreading during mass gatherings.
Article
Public, Environmental & Occupational Health
Simopekka Vanska, Tapio Luostarinen, Camilla Lagheden, Carina Eklund, Sara Nordqvist Kleppe, Bengt Andrae, Par Sparen, Karin Sundstrom, Matti Lehtinen, Joakim Dillner
Summary: The study analyzed HPV genotyping data from Sweden between 2002 and 2011 to estimate age-specific cervical cancer incidence by HPV type and the impact of removing different types of HPV. The results showed that after eliminating vaccine-protected HPV types, very few cases of cervical cancer will be left, especially among fertile, reproductive-age women.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Clinical Neurology
Johan Lundin Kleberg, Jens Hogstrom, Karin Sundstrom, Andreas Frick, Eva Serlachius
Summary: The study found that youth with SAD are slower in shifting attention away from the eyes of others compared to healthy controls, but do not differ in orienting towards eyes. This may contribute to the aversive experience of eye contact for them, and could be a maintaining factor of childhood SAD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Immunology
Wei Wang, Smita Kothari, Marc Baay, Suzanne M. Garland, Anna R. Giuliano, Mari Nygard, Christine Velicer, Joseph Tota, Anushua Sinha, Jozica Skufca, Thomas Verstraeten, Karin Sundstrom
Summary: Observational studies on vaccine effectiveness and impact are crucial for assessing the real-world effects of vaccines, with careful selection of study design, data sources, and analytical methods to mitigate bias. Global monitoring of public health interventions like HPV vaccination programs is becoming easier with access to real-world data, but robust methodology is needed to ensure accurate evaluation of vaccine effects and health policy decisions. A critical appraisal of methodology used in these studies can guide future research and evaluation of HPV vaccination programs globally.
EXPERT REVIEW OF VACCINES
(2022)
Article
Oncology
Jiayao Lei, Laila Sara Arroyo-Muehr, Camilla Lagheden, Carina Eklund, Sara Nordqvist Kleppe, Miriam Elfstroem, Bengt Andrae, Par Sparen, Joakim Dillner, Karin Sundstroem
Summary: By incorporating deep sequencing and a longer follow-up period, this study assessed the association between HPV infection and prognosis in invasive cervical cancer. The results showed that the all-cause mortality was significantly lower in the hrHPV-positive group compared to the hrHPV-negative group, highlighting the importance of hrHPV status in cervical cancer prognosis.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
James E. Barrett, Chiara Herzog, Allison Jones, Olivia C. Leavy, Iona Evans, Susanne Knapp, Daniel Reisel, Tatiana Nazarenko, Yoo-Na Kim, Dorella Franchi, Andy Ryan, Joanna Franks, Line Bjorge, Michal Zikan, David Cibula, Nadia Harbeck, Nicoletta Colombo, Frank Dudbridge, Louise Jones, Karin Sundstrom, Joakim Dillner, Angelique Floter Radestad, Kristina Gemzell-Danielsson, Nora Pashayan, Martin Widschwendter
Summary: The study developed a DNA methylation-based index called WID-BC-index that can identify women with breast cancer using cervical samples, with high accuracy. The researchers also found that CpGs at progesterone receptor binding sites, which are hypomethylated in breast tissue of women with breast cancer, are also hypomethylated in cervical samples of women with poor prognostic breast cancer, indicating a systemic epigenetic programming defect prevalent in women who develop breast cancer. Validation of the WID-BC-index may have clinical implications in monitoring breast cancer risk.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Wei (Vivian) Wang, Smita Kothari, Jozica Skufca, Anna R. Giuliano, Karin Sundstrom, Mari Nygard, Carol Koro, Marc Baay, Thomas Verstraeten, Alain Luxembourg, Alfred J. Saah, Suzanne M. Garland
EXPERT REVIEW OF VACCINES
(2022)
Article
Oncology
Chiara Herzog, Fatima Marin, Allison Jones, Iona Evans, Daniel Reisel, Elisa Redl, Lena Schreiberhuber, Sonia Paytubi, Beatriz Pelegrina, Alvaro Carmona, Paula Peremiquel-Trillas, Jon Frias-Gomez, Marta Pineda, Joan Brunet, Jordi Ponce, Xavier Matias-Guiu, Silvia de Sanjose, Laia Alemany, Adeola Olaitan, Michael Wong, Davor Jurkovic, Emma J. Crosbie, Adam N. Rosenthal, Line Bjorge, Michal Zikan, Lukas Dostalek, David Cibula, Karin Sundstrom, Joakim Dillner, Laura Costas, Martin Widschwendter
Summary: The study developed a noninvasive triage test for women with suspected endometrial cancer symptoms, aiming to improve early diagnosis and reduce the need for in-person visits. The test showed high sensitivity and specificity in detecting EC cases in different sample types and settings.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Genetics & Heredity
James E. Barrett, Karin Sundstrom, Allison Jones, Iona Evans, Jiangrong Wang, Chiara Herzog, Joakim Dillner, Martin Widschwendter
Summary: The WID-CIN test, using DNA methylation markers, accurately identifies HR-HPV positive women with CIN3+ lesions, allowing for early diagnosis. This test has high sensitivity and specificity, offering guidance for clinical decision-making and cervical cancer screening.
Review
Immunology
Wei (Vivian) Wang, Smita Kothari, Hanane Khoury, Linda Niccolai, Suzanne M. Garland, Karin Sundstrom, Gerard de Pouvourville, Paolo Bonanni, Ya-Ting Chen, Eduardo L. Franco
Summary: Assessing progress towards global elimination of cervical cancer requires monitoring vaccination coverage and its impact. A review of HPV-related data systems from seven high-income countries revealed differences in development approach, geographical scope, and data collection methods. The information provided by these data systems can inform improvements to existing prevention programs and the implementation of new programs in other countries.
EXPERT REVIEW OF VACCINES
(2023)
Article
Oncology
James E. Barrett, Allison Jones, Iona Evans, Chiara Herzog, Daniel Reisel, Adeola Olaitan, Tim Mould, Nicola MacDonald, Konstantinos Doufekas, Claire Newton, Emma J. Crosbie, Line Bjorge, Nicoletta Colombo, Lukas Dostalek, Laura Costas, Paula Peremiquel-Trillas, Jordi Ponce, Xavier Matias-Guiu, Michal Zikan, David Cibula, Jiangrong Wang, Karin Sundstroem, Joakim Dillner, Martin Widschwendter
Summary: To reduce the morbidity caused by aggressive treatment for advanced endometrial cancer, it is necessary to identify women at risk and detect the cancer earlier. A new test called WID-EC based on DNA methylation was developed and validated in different sets of samples, showing promising results in identifying women with or at risk of endometrial cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Chiara Herzog, Karin Sundstrom, Allison Jones, Iona Evans, James E. Barrett, Jiangrong Wang, Elisa Redl, Lena Schreiberhuber, Laura Costas, Sonia Paytubi, Lukas Dostalek, Michal Zikan, David Cibula, Gaby Sroczynski, Uwe Siebert, Joakim Dillner, Martin Widschwendter
Summary: This study developed an automatable triage test for cervical screening that is highly sensitive and specific in predicting the risk of progression to CIN3+ in HPV+ patients. The test demonstrated a sensitivity of 100% for detecting invasive cancer and 78% for detecting CIN3, with a specificity of 90%. It also identified 52% of women aged 30 and above with a negative cytology index sample who were later diagnosed with CIN3 within 1-4 years.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Chiara Herzog, Charlotte D. D. Vavourakis, James E. E. Barrett, Gerlinde Karbon, Andreas Villunger, Jiangrong Wang, Karin Sundstrom, Joakim Dillner, Martin Widschwendter
Summary: This study investigated the changes in the host epigenome induced by HPV infection and found that the WID-HPV can reflect the changes in the healthy host epigenome related to high-risk HPV infection. Interestingly, an increased WID-HPV index was observed in patients with minor cytological alterations, suggesting a successful viral clearance response. However, this response was not observed in patients with precancerous changes or invasive cervical cancer. Further analysis revealed that the WID-HPV is associated with apoptosis and the epigenetic replicative age.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Ane K. K. Bennetsen, Mette T. Faber, Mari Nygaard, Karin Sundstrom, Bo T. Hansen, Louise T. Thomsen, Christian Munk, Kirsten Frederiksen, Susanne K. Kjaer
Summary: Early smoking and drinking initiation, as well as non-use of contraceptives at first sexual intercourse, were associated with teenage pregnancy regardless of age at first sexual intercourse. This emphasizes the necessity of focusing on early risk-taking behavior as a potential modifier to prevent teenage pregnancy.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Jiangrong Wang, K. Miriam Elfstrom, Camilla Lagheden, Carina Eklund, Karin Sundstrom, Par Sparen, Joakim Dillner
Summary: This study estimated the impact of cervical screening and follow-up for different types of HPV and found that HPV 16 and HPV 18 are the most common and oncogenic types, playing a significant role in the prevention and treatment of cervical cancer.
Article
Public, Environmental & Occupational Health
Jiangrong Wang, Eva Herweijer, Sara Nordqvist Kleppe, Susanne Hartwig, Christine Velicer, Carol Koro, Karin Sundstrom
Summary: This study describes the HPV vaccination coverage among girls eligible for vaccination in Sweden's childhood immunization program and provides an estimate on dose timing compliance. The results show that coverage with at least one dose of the vaccine was over 80% in girls born between 2001 and 2006. The completion rate for the two-dose and three-dose regimen was 91.8% and 72.8% respectively. The study concludes that it is important to further improve vaccination coverage and reach out to girls who are not fully vaccinated or partially engaged with the vaccine in order to fully benefit from HPV vaccination.
PREVENTIVE MEDICINE REPORTS
(2023)