期刊
JOURNAL OF INTERNAL MEDICINE
卷 280, 期 5, 页码 457-464出版社
WILEY
DOI: 10.1111/joim.12562
关键词
atherosclerosis; calcium; diabetes mellitus; insulin resistance; metabolic syndrome
The burden of type 2 diabetes and its major complication cardiovascular disease is rapidly increasing worldwide. Understanding the underlying pathogenic mechanisms of these diseases is crucial to develop novel therapeutics. Recent work using genetic and biochemical methods in mouse models and human samples have identified disturbed calcium signalling and endoplasmic reticulum stress as emerging factors involved in the pathogenesis of many metabolic diseases. In this review, we will highlight the specific roles of calcium signalling and endoplasmic reticulum stress response in the development of insulin resistance and atherosclerosis.
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