Review
Health Care Sciences & Services
Paul Ishiyama, Gail Ishiyama, Ivan A. A. Lopez, Akira Ishiyama
Summary: Since its FDA approval in 1984, cochlear implantation has been successfully used for restoring hearing in individuals with severe to profound hearing loss. It has also been applied to cases of single-sided deafness, hybrid electroacoustic stimulation, and implantation at different ages. The design of cochlear implants has evolved to improve processing technology and reduce surgical trauma and foreign body reaction.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alberto Rabano, Carmen Guerrero Marquez, Ramon A. Juste, Maria V. Geijo, Miguel Calero
Summary: The study on the lesion profile of medial temporal lobe in human prion disease patients revealed diverse profiles for different types and subtypes of HPD, with mixed tissue types showing a higher impact on MTL lesion profile. These results may contribute to the analysis of possible strain effects in focal non-prion neurodegenerative conditions limited to the MTL.
Review
Neurosciences
Marino Muxfeldt Bianchin, Zhezu Snow
Summary: Microglia are unique cells in the central nervous system, with diverse functions including monitoring microregions and maintaining neural tissue integrity. Dysfunction of microglia can lead to neurological and psychiatric disorders, and is associated with genetic mutations. Additionally, certain variants are associated with Alzheimer's disease.
Article
Health Care Sciences & Services
Noura Alothman, Fida Almuhawas, Reem Badghaish, Al Hanouf Alotaibi, Salman F. Alhabib, Farid Alzhrani, Abdulrahman Hagr
Summary: This study aimed to investigate the impact of insertion depth and position of cochlear implant (CI) electrode arrays on speech perception. The results showed that cochlear coverage was related to speech performance, with higher coverage associated with better speech discrimination score (SDS). The findings of this study are of significant importance for the outcomes of CI recipients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Nawaf Fatani, Nezar Hamed, Abdulrahman Hagr
Summary: This study reviewed the experience of simultaneous bilateral cochlear implantation (BiCI) in adults and assessed its feasibility. It found that simultaneous BiCI is feasible in adults without major complications, offering potential benefits by reducing the number of surgeries and hospital admissions compared to the sequential method.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Yuan-Siao Chen, Ernesto Cabrera, Brady J. Tucker, Timothy J. Shin, Jasmine Moawad, Douglas J. Totten, Kevin T. Booth, Rick F. Nelson
Summary: Cochlear implantation (CI) has favorable outcomes for patients with TMPRSS3-associated hearing loss, with no significant difference in word scores compared to adult CI patients. The low expression of TMPRSS3 in auditory neurons suggests its minor role in auditory function.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Multidisciplinary Sciences
Marco Caversaccio, Georgios Mantokoudis, Franca Wagner, Philipp Aebischer, Stefan Weder, Wilhelm Wimmer
Summary: This article provides a comprehensive overview of the clinical workflow for robotic cochlear implantation. It covers various steps such as patient assessment, surgical preparation, preoperative planning, drilling, intraoperative imaging, milling, electrode insertion, and implant management. The procedure requires collaboration among experts from different disciplines and training to ensure a smooth and safe surgery.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Medicine, General & Internal
Goun Choe, Young Seok Kim, Seung-Ha Oh, Sang-Yeon Lee, Jun Ho Lee
Summary: This study provides fresh evidence on the effectiveness of cochlear implantation in patients with cochlear nerve aplasia. The results show that while the Categories of Auditory Performance scores gradually improve after cochlear implantation, there are individual variations in outcomes. Patients with lower scores at 1-year postoperative evaluation find it difficult to improve their auditory performance even after 3 years, while those with higher scores show improved performance. Intraoperative electrically evoked compound action potential is not correlated with postoperative auditory performance scores.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, Research & Experimental
Tayla Razmovski, Kate M. Brody, Dimitra Stathopoulos, Dongcheng Zhang, Ellie Cho, Amy J. Hampson, Aaron Collins, Christofer Bester, Stephen O'Leary
Summary: Intraoperative trauma leading to bleeding during cochlear implantation negatively impacts residual hearing of cochlear implant recipients. This preclinical study investigated the implementation of an intra-cochlear flushing protocol for the removal of blood, which resulted in better auditory function and reduced subsequent fibrosis in the basal region of the cochlea.
Article
Medicine, General & Internal
Xue Gao, Juan Zhao, Guan-Hua Li, Xi Wang, Wei Wang, Xing Liu, Min Liu, Meng-Meng Guo, Zhen-Dong Wang, Ya-Yan Lu, Jia Li, Yong Feng, Kun Yang, Jin-Cao Xu, Pu Dai
Summary: This study reports the case of a 28-month-old girl with congenital profound hearing loss, laryngomalacia, and malformed inner ear, who received cochlear implantation surgery. The genetic basis was determined using trio-based whole exome sequencing, and perioperative evaluation and management of the airway was performed by an experienced anesthesiologist. Cochlear implantation was eventually performed successfully under uneventful general anesthesia.
Article
Otorhinolaryngology
Geethanjeli N. Mahendran, Tyler Rosenbluth, Miriam Featherstone, Esther X. Vivas, Douglas E. Mattox, Candace E. Hobson
Summary: This study compared rates of cochlear implant referral and implantation among different races, finding that Black patients had significantly worse hearing and worse outcomes compared to White and Asian patients. Though Black patients had lower referral and implantation rates, there was no significant difference in implantation rates between Black and White patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Clinical Neurology
Sarah E. Hodge, Gail Ishiyama, Ivan A. Lopez, Akira Ishiyama
Summary: This study focused on analyzing changes in osteoneogenesis and fibrosis following cochlear implant surgery in otosclerosis patients, comparing differences based on insertion technique. The cochleostomy approach was associated with significant fibrosis, osteoneogenesis, and cochlear hydrops, while the round window insertion technique helped minimize these histopathologic findings.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Clinical Neurology
Graham M. Winston, Miguel E. Tusa Lavieri, Francis Michael Villamater, Theodore H. Schwartz
Summary: Anteromesial resection is an effective treatment for seizures arising from the medial temporal lobe. However, the need for electrode implantation before surgery may not significantly affect the rate of seizure freedom in these patients. Our study suggests that omitting electrode implantation may lead to improved seizure control.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Neil S. Patel, Matthew L. Carlson, Michael J. Link, Brian A. Neff, Jamie J. Van Gompel, Colin L. W. Driscoll
Summary: The study reviewed outcomes of cochlear implantation (CI) following stereotactic radiosurgery (SRS) for vestibular schwannoma (VS) in a single tertiary care referral center from 1990 to 2019. Most patients who underwent CI following SRS for VS enjoyed access to sound at near-normal levels, with the majority achieving good open-set speech understanding.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Taro Nakazawa, Tomoyuki Ohara, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Mao Shibata, Takanori Honda, Takanari Kitazono, Tomohiro Nakao, Toshiharu Ninomiya
Summary: The aim of this study was to investigate the association between white matter lesions volume (WMLV) levels and dementia risk, as well as the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population. The study found that the risk of dementia significantly increased with higher levels of WMLV/ICV. Additionally, a additive increase in dementia risk was observed with higher levels of WMLV/ICV and lower levels of TBV/ICV or a higher number of dementia-related brain regional atrophy.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Behavioral Sciences
Anuprasad Sreenivasan, Rajalakshmi Krishna, Pradeep Pankajakshan Nair, Ananthanarayanan Kasinathan, Arun Alexander
Summary: The study evaluated the auditory spectral resolution abilities of children with Benign epilepsy with centrotemporal spikes, finding that these children had significantly lower spectral resolution thresholds compared to controls.
EPILEPSY & BEHAVIOR
(2021)
Article
Otorhinolaryngology
Aparna Das, Karthikeyan Ramasamy, Saranya Thangavel, Rashmi Hansdah, Arun Alexander, Sunil Kumar Saxena
Summary: In this retrospective study, 20 patients with foreign body esophagus were reviewed, with 5 of them having associated retropharyngeal abscess. Internal drainage of pus resulted in significant improvement in patients, who were discharged within a week.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Dharanya Gopalakrishnan Srinivasan, Jyotirmay Hegde, Karthikeyan Ramasamy, Kalaiarasi Raja, Sathish Rajaa, Sivaraman Ganesan, Prabu Velayutham, Arun Alexander, Sunil Kumar Saxena
Summary: The study aimed to evaluate the efficacy of septoplasty compared to medical management in relieving nasal obstruction due to deviated nasal septum, with results showing that surgical correction of deviated nasal septum through septoplasty improves nasal obstruction better than nonsurgical management at 6 months post-surgery.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Saravanan Palani, Arun Alexander, Anuprasad Sreenivasan
Summary: This study assessed the effects of probe-tone frequency on ESRT in pediatric cochlear implant users and its relationship with behavioral comfort levels. The results showed that ESRT levels were lower with higher-frequency probe tones and significantly correlated with comfort levels.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Soorya Pradeep, Arun Alexander
Editorial Material
Medicine, General & Internal
Stuti Chowdhary, Arun Alexander, Subhashini Puducherry Ravichandran, Lokesh Kumar Penubarthi
Article
Surgery
Sauradeep Das, Raghul Sekar, Arun Alexander, Sivaraman Ganesan
Summary: This report presents a rare variant of TGDC that emerges within the tongue base, which was successfully managed by transoral robotic surgery using the Da Vinci Robotic system. The surgery was effective and reliable, with no complications or recurrence on follow up. Further studies are needed to confirm the safety and recurrence rates of this technique in paediatric population.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2023)
Article
Otorhinolaryngology
Stuti Chowdhary, Saranya Thangavel, Jijitha Lakshmanan, Sunil Kumar Saxena
Summary: Orbital epidermoid cysts are rare lesions associated with symptoms related to the eye and sino-nasal system. Cross-sectional imaging is valuable for assessing the size and extent of the cysts. The use of an endoscope can aid in exploring the extent of the lesion and achieving complete surgical clearance.
TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Surgery
Sauradeep Das, Saranya Thangavel, Kalaiarasi Raja, Sunil Kumar Saxena
Summary: The outbreak of COVID-19 has made the management of foreign body in the trachea and bronchus more complicated and challenging, as patients are reluctant to seek medical treatment, posing challenges for hospitals and healthcare workers.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2022)
Review
Surgery
Saranya Thangavel, Pampa Ch Toi, Sivaraman Ganesan, Arun Alexander, Sunil Kumar Saxena
Summary: Plasma cell granuloma is a rare, benign lesion that typically occurs in young adults, with the lungs being the most common site. Surgery is the best treatment option, and the condition usually does not pose life-threatening complications.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2022)
Review
Surgery
Antony Raj James, Saranya Thangavel, Kalaiarasi Raja, Sunil Kumar Saxena
Summary: Vegetable matter, particularly fruit seed impaction, is a rare occurrence in otolaryngology practice, but when it does happen, there may be a connection to esophageal abnormalities. This case study presents a patient with a history of left buccal mucosa carcinoma who had radiotherapy 20 years prior, and experienced fruit seed impaction in the esophagus, highlighting the practical and logistical challenges of intubation and esophagoscopy in such cases.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2021)
Article
Medicine, General & Internal
Stuti Chowdhary, Saranya Thangavel, Sivaraman Ganesan, Arun Alexander
Summary: Schwannomas of the eighth nerve are common and often associated with neurofibromatosis-2; however, seventh nerve schwannomas, especially in an extratemporal course, are rare. Histopathology is essential for confirming the diagnosis of facial nerve schwannoma, and atypical diagnoses should be considered when facial palsy is present without other etiological factors.
Article
Medicine, General & Internal
Saranya Thangavel, Lokesh Kumar Penubarthi, Arun Alexander, Sunil Kumar Saxena
Summary: The case report discusses a adolescent with mental retardation who had congenital aural atresia and contralateral congenital facial palsy, with multiple intracranial complications due to cholesteatoma. A multidisciplinary approach was used for management, with emphasis on meticulous intraoperative steps and precautions to avoid postoperative complications.
