Article
Chemistry, Applied
Mei Zhang, Sajid Asghar, Cihui Tian, Ziyi Hu, Qineng Ping, Zhipeng Chen, Feng Shao, Yanyu Xiao
Summary: The study developed reduction-sensitive dual-targeting nanogels for glioma therapy, showing excellent drug release and cytotoxicity, providing a novel solution for glioma treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Biomaterials
Hiroya Shiba, Misaki Nishio, Mei Sawada, Mamiko Tamaki, Masataka Michigami, Shinya Nakai, Ikuhiko Nakase, Ikuo Fujii, Akikazu Matsumoto, Chie Kojima
Summary: The study demonstrates that Phe- and CHex-modified dendrimers can serve as pH-sensitive drug delivery systems for T cells, enhancing cellular uptake.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Liangliang Cai, Ronghua Ni, Xiaofei Ma, Rongrong Huang, Zhiyuan Tang, Jinqiu Xu, Yong Han, Yuehua Guo, Zhifeng Gu
Summary: Nanomicelles combining nanotechnology-assisted photothermal therapy (PTT) and a novel HSP90 inhibitor AT13387 can achieve mutually synergistic PTT/molecularly targeted therapy (MTT) for the precise treatment of triple-negative breast cancer (TNBC).
Article
Engineering, Biomedical
Minjun Ye, Bingyi Li, Wanyu Shi, Huaize Liu, Yi Wang, Weiqing Chen, Jian Wang, Guixue Wang
Summary: Radiation therapy is commonly used in the treatment of tumors, but it often causes damage to normal tissues. Boron neutron capture therapy (BNCT) is a targeted approach that has shown advantages in tumor treatment. This study developed a tumor-targeting nano-boron drug by using albumin as a drug carrier and modifying the nanoparticles with hyaluronic acid. The results showed that the modified nanoparticles effectively delayed drug release, enhanced aggregation in tumors, and had good safety with no noticeable toxicity. These findings provide valuable insights for the application of boron drugs in BNCT.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Pharmacology & Pharmacy
Lubna Siddiqui, Nazeer Hasan, Pawan K. Mishra, Neha Gupta, Anu T. Singh, Alka Madaan, Manu Jaggi, Suma Saad, Adam Ekielski, Zeenat Iqbal, Prashant Kesharwani, Sushama Talegaonkar
Summary: Hyaluronic acid (HA) coated irinotecan loaded lignin nanoparticles (HDLNPs) were synthesized and characterized for their targeted chemotherapeutic potential. The studies demonstrated improved chemotherapeutic efficacy, antioxidant activity, and prolonged drug localization in tumor sites using HDLNPs. Additionally, HDLNPs were found to prevent irinotecan-associated side effects and maintain stability over a long period.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Keita Yamana, Riku Kawasaki, Yu Sanada, Anri Tabata, Kaori Bando, Kouhei Yoshikawa, Hideki Azuma, Yoshinori Sakurai, Shin-ichiro Masunaga, Minoru Suzuki, Kouta Sugikawa, Takeshi Nagasaki, Atsushi Ikeda
Summary: The study introduced a fluorescent nano complex for high boron concentration and tumor-selectivity in cancer therapy, which could be actively internalized by tumor cells and exhibited excellent cytotoxicity post-thermal neutron irradiation, potentially offering a more suitable alternative to boron agents in BNCT.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Renshuai Zhang, Xiaohua Zhao, Ang Jia, Chao Wang, Hongfei Jiang
Summary: Hyaluronic acid (HA) is a natural polysaccharide that has gained significant attention for its improved tumor targeting capacity, enzyme degradation capacity, and excellent biocompatibility. Its receptor, CD44, is overexpressed in various cancer cells and is closely related to tumor progress and metastasis. Therefore, researchers have designed HA-based drug delivery platforms for CD44-mediated tumor targeting. HA-based nanoprodrugs possess distinct advantages such as good bioavailability, long circulation time, and controlled drug release and retention ability, and have been extensively studied in the past years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Mengru Yang, Ying Zhang, Zheming Hu, Haonan Xie, Wenli Tian, Zhidong Liu
Summary: This article summarizes the application of hyaluronic acid-based nanoparticles in combination therapy for cancer treatment. These nanoparticles have exceptional biocompatibility and targeting capabilities, offering a new approach for precise drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Oncology
Mei-Chi Su, Susheel Kumar Nethi, Pavan Kumar Dhanyamraju, Swayam Prabha
Summary: The tumor microenvironment has a significant impact on the effectiveness of cancer treatments. Recent studies have focused on using stromal modulators and nanomedicine therapeutics to reprogram the tumor microenvironment. This review examines the major stromal components and recent advances in stroma-targeted therapies for cancer treatment.
Article
Nanoscience & Nanotechnology
Gu Gong, Xiuhui Tang, Jiayuan Zhang, Xiao Liang, Jiebing Yang, Quanshun Li
Summary: The phenylboronic acid-modified polyamidoamine (PP) was used as a carrier for delivering Polo-like kinase-1 siRNA, leading to a significant anti-tumor response in hepatocarcinoma cells. The PP/siPlk-1 nanoparticles exhibited strong anti-proliferation effects and could efficiently suppress the migration and invasion of tumor cells. The derivative PP holds great potential as an ideal tumor-targeting carrier for gene therapy in malignant tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Tingting Peng, Yao Huang, Xiaoqian Feng, Chune Zhu, Shi Yin, Xinyi Wang, Xuequn Bai, Xin Pan, Chuanbin Wu
Summary: The utilization of dissolving microneedles for locally delivering functionalized nanoparticles with combined chemotherapy and photothermal therapy has shown promising results in enhancing anti-tumor effects and reducing adverse reactions.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Medicine, Research & Experimental
Wenguang Wang, Xingli Wang, Feng Tao, Kaiyuan Hu, Junying Zhang, Jinhui Wu, Linjun You, Weijun Zhao
Summary: In this study, O-2@PFC@FHA NPs were developed to deliver oxygen safely and specifically to tumors, thereby relieving tumor hypoxia. The combination of radiotherapy with O-2@PFC@FHA NPs resulted in almost threefold therapeutic improvement compared with radiotherapy alone, without causing obvious systemic toxicity.
MOLECULAR PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Talita Nascimento da Silva, Emanuelle V. de Lima, Thais Nogueira Barradas, Carla G. Testa, Paulo H. S. Picciani, Claudia P. Figueiredo, Flavia A. do Carmo, Julia R. Clarke
Summary: Several human pathogens can cause long-lasting neurological damage, and gene therapy (GT) approaches have been explored as a potential therapeutic intervention. Viral and non-viral vectors are used for gene delivery, with non-viral vectors showing promise due to their safety and versatility. Different types of nanosystems are applied as non-viral vectors, and they can help deliver gene-modifying molecules to prevent neurological damage associated with infectious diseases.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Mengying Zhang, Huimin Yu, Jinglu Hu, Zhengyu Zhao, Lei Liu, Gaomin Yang, Tingli Wang, Guang Han, Shiyong Song
Summary: This study prepared a nanocarrier based on hyaluronic acid and solanesol, which showed great potential in cancer therapy. Loading doxorubicin into the nanocarrier enabled pH-sensitive drug release, with lower cardiotoxicity and hepatotoxicity compared to free doxorubicin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Sheng Wang, Jingwen Zhang, Wei Li, Dali Chen, Jiasheng Tu, Chunmeng Sun, Yunai Du
Summary: Oxidative stress is a key characteristic of atherosclerosis, contributing to the oxidation of lipids and damage to macrophages. This study introduces a novel plaque-targeting ROS scavenger composed of hyaluronic acid-guided assemblies of ceria nanozymes, which effectively remove excess ROS and protect macrophages in atherosclerotic plaques.
CARBOHYDRATE POLYMERS
(2022)
Article
Biophysics
Xiaole Qi, Yao Rui, Yuchao Fan, Haiyan Chen, Ning Ma, Zhenghong Wu
COLLOIDS AND SURFACES B-BIOINTERFACES
(2015)
Article
Nanoscience & Nanotechnology
Xiaole Qi, Jiayi Qin, Yuchao Fan, Xiaoxue Qin, Yujie Jiang, Zhenghong Wu
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2016)
Article
Nanoscience & Nanotechnology
Yuchao Fan, Shengxiao Yuan, MengMeng Huo, Arka Sen Chaudhuri, Meihui Zhao, Zhenghong Wu, Xiaole Qi
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2017)
Article
Engineering, Biomedical
Yuchao Fan, Zhilian Yue, Enrico Lucarelli, Gordon G. Wallace
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Engineering, Biomedical
Ying Zhou, Yuchao Fan, Zhi Chen, Zhilian Yue, Gordon Wallace
Summary: The development of a catechol functionalized ink system provides a platform for creating tough and elastic scaffolds with built-in micro channels that mimic vascular structure. These scaffolds, produced using 3D printing, support the formation of a double-layered cell-laden skin-like structure, indicating their potential for skin regeneration.
Article
Chemistry, Applied
Mengmeng Huo, Wenyan Li, Arka Sen Chaudhuri, Yuchao Fan, Xiu Han, Chen Yang, Zhenghong Wu, Xiaole Qi
CARBOHYDRATE POLYMERS
(2017)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
