Novel hydroxyl carboximates derived from β-elemene: design, synthesis and anti-tumour activities evaluation

Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma

(2022) Renren Bai et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification

(2021) Ziqiang Bai et al.   MOLECULES

Novel Selective Histone Deacetylase 6 (HDAC6) Inhibitors: A Patent Review (2016-2019)

(2020) Xingrui He et al.   Recent Patents on Anti-Cancer Drug Discovery

β-Elemene derivatives produced from SeO 2 -mediated oxidation reaction

(2020) Xingrui He et al.   Royal Society Open Science

Dual inhibitors of histone deacetylases and other cancer-related targets: A pharmacological perspective

(2020) Yuan Gao et al.   BIOCHEMICAL PHARMACOLOGY

Rational Design, Synthesis and Biological Evaluation of Novel Derivatives Based on in vivo Metabolism of Natural Product β-elemene

(2018) Renren Bai et al.   Letters in Drug Design & Discovery

Elemene injection as adjunctive treatment to platinum-based chemotherapy in patients with stage III/IV non-small cell lung cancer: a meta-analysis following the PRISMA guidelines

(2018) Xuewei Wang et al.   PHYTOMEDICINE

β-Elemene Synergizes With Gefitinib to Inhibit Stem-Like Phenotypes and Progression of Lung Cancer via Down-Regulating EZH2

(2018) Haibo Cheng et al.   Frontiers in Pharmacology

Discovery of novel antitumor nitric oxide-donating β -elemene hybrids through inhibiting the PI3K/Akt pathway

(2017) Jichao Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel hybrids of natural β -elemene bearing isopropanolamine moieties: Synthesis, enhanced anticancer profile, and improved aqueous solubility

(2017) Jichao Chen et al.   FITOTERAPIA

Antioxidant Properties of Novel Dimers Derived from Natural β-Elemene through Inhibiting H2O2-Induced Apoptosis

(2017) Jichao Chen et al.   ACS Medicinal Chemistry Letters

β-elemene Induces Caspase-dependent Apoptosis in Human Glioma Cells in vitro through the Upregulation of Bax and Fas/FasL and Downregulation of Bcl-2

(2015) Chen-Long Li et al.   Asian Pacific Journal of Cancer Prevention

Design, synthesis and antioxidant activity evaluation of novel β-elemene derivatives

(2014) Jichao Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ETME, a novel β-elemene derivative, synergizes with arsenic trioxide in inducing apoptosis and cell cycle arrest in hepatocarcinoma cells via a p53-dependent pathway

(2014) Zhiying Yu et al.   Acta Pharmaceutica Sinica B

Synthesis, characterization, and in vitro antiproliferative activity of novel β-elemene monosubstituted derivatives

(2013) Guifeng Liu et al.   MEDICINAL CHEMISTRY RESEARCH

β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis

(2011) Jing Liu et al.   BMC CANCER

β-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

(2011) Zhiying Yu et al.   PLoS One

Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone

(2010) Alejandro F. Barrero et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and radiolabelling of Re(CO)3-β-elemene derivatives as potential therapeutic radiopharmaceuticals

(2009) Yunfeng Ren et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis and in vitro anti-proliferative activity of β-elemene monosubstituted derivatives in HeLa cells mediated through arrest of cell cycle at the G1 phase

(2008) Yanhong Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY