Article
Agriculture, Dairy & Animal Science
Jefferson R. Gandra, Cibeli A. Pedrini, Nara R. B. Consolo, Anderson P. Acosta, Leonardo O. Seno, Luis C. G. S. Barbosa, Isabelle Z. Noia, Vicente L. M. Buarque, Angel R. H. Padilla, Luis A. Colnago, Erika R. S. Gandra
Summary: This study found that adding probiotics to the pre-weaning diet of Senepol calves can improve their performance and weight at weaning, as well as increase muscle and fat deposition on the carcass. Furthermore, probiotics also enhance protein and fatty acid metabolism, immune system response, and rumen development.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
G. P. Shen, Z. N. Ding, T. Dai, J. H. Feng, J. Y. Dong, F. Xia, J. J. Xu, J. D. Ye
Summary: This study aimed to investigate the effects of taurine supplementation on the metabolic profiles of Nile tilapia, highlighting improvements in carbohydrate synthesis, protein digestion and fat deposition. The results suggest that 0.8% taurine supplementation can significantly enhance the metabolic processes in fish, promoting growth and development.
Article
Chemistry, Analytical
G. A. Nagana Gowda, Vadim Pascua, Camerin E. Killion, Rajan K. Paranji, Daniel Raftery
Summary: Phosphorus metabolites play a critical role in cellular function, but their detection and quantification pose challenges. This study presents a method using simple 1D P-31 NMR spectrum to analyze multiple phosphorus metabolites in blood and establish the identification of unknown metabolites. The method provides visualization and quantification of intermediates and products of various metabolic pathways.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Soumya K. Kar, Marinus F. W. te Pas, Leo Kruijt, Jacques J. M. Vervoort, Alfons J. M. Jansman, Dirkjan Schokker
Summary: This study used fecal metabolite profiling to evaluate the effects of different sanitary conditions on the subclinical health status of pigs. The results showed that the fecal metabolite profiles reflected the sanitary conditions of the pigs and closely resembled the metabolite profiles found in their colon. Fecal valerate and kynurenic acid could potentially serve as non-invasive biomarkers for monitoring the immune or inflammatory status of pigs.
Article
Biochemistry & Molecular Biology
Lilliam Ambroggio, Todd A. Florin, Kayla Williamson, Cory Pfefferman, Brandie D. Wagner, Larisa Yeomans, Jae Hyun Kim, Heidi Sucharew, Maurizio Macaluso, Richard M. Ruddy, Samir S. Shah, Kathleen A. Stringer
Summary: The study found that there may be short-term changes in the urinary metabolome of healthy children, but levels of metabolites did not differ significantly in children with viral carriage or Streptococcus pneumoniae detected.
Article
Biochemical Research Methods
Jane Shearer, Matthias S. Klein, Hans J. Vogel, Shuhiba Mohammad, Shannon Bainbridge, Kristi B. Adamo
Summary: Pre-pregnancy obesity and excessive gestational weight gain are risk factors for future maternal and childhood obesity. Maternal obesity may affect the fetus through metabolic changes. Maternal serum metabolites show distinct profiles for different weight statuses, and certain metabolites can predict excessive gestational weight gain.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Psychiatry
Xiao-Li Sun, Li-Na Ma, Zhen-Zhu Chen, Yan-Bing Xiong, Jiao Jia, Yu Wang, Yan Ren
Summary: This study found significant differences in the metabolic phenotypes between bipolar disorder (BD), major depressive disorder (MDD), and healthy controls. Glycerolipid metabolism was significantly involved in both BD and MDD, while pyruvate metabolism was significantly involved in MDD. Pyruvate, choline, and acetate may be potential biomarkers for distinguishing MDD from BD, and pantothenic acid may be a potential biomarker for distinguishing BD from MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Jenni Puurunen, Claudia Ottka, Milla Salonen, Julia E. Niskanen, Hannes Lohi
Summary: Metabolomics has vast potential in biomedical applications. Factors such as age, breed, sex, sterilization, diet type, and fasting time significantly affect the metabolite profiles of healthy pet dogs, with breed and age causing considerable variation in metabolite concentrations.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Food Science & Technology
Min Huang, Xue Zhao, Yihan Mao, Lin Chen, Hongshun Yang
Summary: The study identified 22 compounds in sponge cake after in vitro digestion, with Eucheuma reducing the release of amino acids and fatty acids. Eucheuma also altered the flow behavior index of the cake during digestion, showing solid-like behavior and decreased viscoelastic moduli in all samples. This study provides a foundation for future optimization of food properties to control their digestive characteristics.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Plant Sciences
Andre Caeiro, Ivana Jarak, Sandra Correia, Jorge Canhoto, Rui Carvalho
Summary: In this study, a protocol of indirect somatic embryogenesis was used to obtain embryogenic and non-embryogenic callus from leaf segments of Tamarillo trees. Nuclear magnetic resonance spectroscopy was used to analyze the primary metabolome of these calli, and the results revealed different metabolic pathways and metabolites between embryogenic and non-embryogenic calli. The levels of fructose, sucrose, and the glucose to sucrose ratio were found to be potential biochemical biomarkers of embryogenic competence.
Article
Veterinary Sciences
Olivia Chiu, Moran Tal, Abbinash Sanmugam, Myriam Hesta, Diego E. Gomez, Jeffrey Scott Weese, Adronie Verbrugghe
Summary: This study investigated the effect of ambient temperature exposure on microbial-derived metabolites of feline fecal samples. The results showed that short-term (up to 4 h) exposure to ambient temperature seems to be acceptable.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Neurosciences
Meaghan V. Perdue, Marilena M. DeMayo, Tiffany K. Bell, Elodie Boudes, Mercedes Bagshawe, Ashley D. Harris, Catherine Lebel
Summary: Metabolites in the brain have important roles in development, with rapid changes during prenatal and infancy stages. However, there is limited research on neurochemistry changes in early-middle childhood. In this study, we analyzed the levels of key metabolites in two brain regions using magnetic resonance spectroscopy in children aged 2-11 years. We found significant age-related changes in metabolite levels, suggesting their involvement in structural and functional brain development.
Article
Biochemistry & Molecular Biology
Yasuhiro Date, Chiaki Ishikawa, Makoto Umeda, Yusuke Tarumoto, Megumi Okubo, Yasuaki Tamura, Hiroshi Ono
Summary: This study aimed to evaluate the variability of sugarcane juice metabolome affected by different pretreatment methods and determine optimal conditions for NMR-based metabolomics. The results showed that the pretreatment processes were compatible and the thermal processing provided stability to the metabolome. NMR-based metabolomics allowed for the successful identification of characteristic metabolites in sugarcane juice.
Article
Chemistry, Analytical
Joanna Niziol, Krzysztof Ossolinski, Brian P. Tripet, Valerie Copie, Adrian Arendowski, Tomasz Ruman
Summary: Metabolic profiling of urine samples from kidney cancer patients and healthy volunteers using H-1 NMR and LDI MS identified potential urine biomarkers and significantly different mass spectral features, providing a framework for biomarker discovery in kidney cancer.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Florence Franconi, Laurent Lemaire, Jean-Christophe Gimel, Samuel Bonnet, Patrick Saulnier
Summary: NMR-based diffusion methods are valuable tools for nanomedicine characterization and understanding interactions with the biological environment. They provide insights into diffusion phenomena and measurement of self-diffusion and mutual diffusion coefficients. NMR diffusometry spectroscopic and imaging methods have broad applications in nanomedicine, aiding in elucidating important issues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemical Research Methods
Cristina Licari, Leonardo Tenori, Francesca Di Cesare, Claudio Luchinat, Betti Giusti, Ada Kura, Rosina De Cario, Domenico Inzitari, Benedetta Piccardi, Mascia Nesi, Cristina Sarti, Francesco Arba, Vanessa Palumbo, Patrizia Nencini, Rossella Marcucci, Anna Maria Gori, Elena Sticchi
Summary: Metabolic perturbations and inflammatory mediators play a fundamental role in adverse post-acute ischemic stroke outcomes. This study found associations between specific metabolic features and outcomes such as hemorrhagic transformation, non-response to thrombolytic treatment, and functional outcome. These metabolic changes indicate a state of energy failure, oxidative stress, and systemic inflammation.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Automation & Control Systems
Maria Frizzarin, Giulio Visentin, Alessandro Ferragina, Elena Hayes, Antonio Bevilacqua, Bhaskar Dhariyal, Katarina Domijan, Hussain Khan, Georgiana Ifrim, Thach Le Nguyen, Joe Meagher, Laura Menchetti, Ashish Singh, Suzy Whoriskey, Robert Williamson, Martina Zappaterra, Alessandro Casa
Summary: In April 2022, the Vistamilk SFI Research Centre organized the second edition of the International Workshop on Spectroscopy and Chemometrics - Applications in Food and Agriculture. During the workshop, a data challenge was conducted to develop a prediction model for distinguishing dairy cows' diet based on milk spectral information. The accurate and reliable discriminant model is essential for ensuring product origin for dairy food manufacturers. Various statistical and machine learning approaches were used, along with different pre-processing steps and levels of complexity. This paper aims to describe the statistical methods employed by participants in developing the classification model.
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
(2023)
Review
Agriculture, Dairy & Animal Science
A. Costa, N. W. Sneddon, A. Goi, G. Visentin, L. M. E. Mammi, E. V. Savarino, F. Zingone, A. Formigoni, M. Penasa, M. De Marchi
Summary: Mammalian colostrum, known as liquid gold, is highly valued for its essential nutrients and bioactive compounds. Bovine colostrum (BC) has emerged as an important ingredient in various industries and is increasingly in demand. However, there is limited information available regarding the market size and future developments of BC. Therefore, this review provides an overview of BC production, its pros and cons, quality assessment methods, industry applications, and the current international market for BC.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
M. Franzoi, G. Niero, G. Meoni, L. Tenori, C. Luchinat, M. Penasa, M. Cassandro, M. De Marchi
Summary: This study evaluates mid-infrared spectroscopy (MIRS) as a rapid method for predicting cow milk metabolites determined through proton nuclear magnetic resonance (1H NMR) spectroscopy. The results show that MIRS can accurately predict certain milk metabolites, but its prediction performance for other metabolites is poor. Further research is needed to explore the practical application of this method in the dairy industry.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Oncology
Edda Russo, Leandro Di Gloria, Giulia Nannini, Gaia Meoni, Elena Niccolai, Maria Novella Ringressi, Simone Baldi, Renato Fani, Leonardo Tenori, Antonio Taddei, Matteo Ramazzotti, Amedeo Amedei
Summary: This study comprehensively investigates the microbial spatial variations and their role in CRC progression, identifying potential microbial and metabolic biomarkers and analyzing and comparing metabolites obtained from CRC and AP patients. The results highlight the importance of microbiota communities and oncometabolites in CRC development.
Article
Biochemistry & Molecular Biology
Francesca Di Cesare, Alessia Vignoli, Claudio Luchinat, Leonardo Tenori, Edoardo Saccenti
Summary: This study analyzed the association networks of serum metabolites and found that the metabolite-metabolite association network of colorectal cancer (CRC) patients is distinct from that of patients with polyposis and healthy controls. Energy metabolism-related nodes play a crucial role in the CRC network.
Article
Veterinary Sciences
Giovanni Buonaiuto, Nicolas Lopez-Villalobos, Angela Costa, Giovanni Niero, Lorenzo Degano, Ludovica Maria Eugenia Mammi, Damiano Cavallini, Alberto Palmonari, Andrea Formigoni, Giulio Visentin
Summary: The present study aimed to investigate the association between stayability traits, muscularity, and body condition score (BCS) in Italian Simmental dual-purpose cows. The results showed that cows with a medium BCS and muscularity in early lactation had a higher likelihood of staying in the herd compared to thinner ones. However, cows with high muscularity were less likely to start the third lactation, indicating a potential preference for market cows with good conformation for meat purpose. This study highlights the importance of muscularity and BCS early in life for the stayability of Simmental cows.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Anton Shiriaev, Stefano Brizzolara, Carlo Sorce, Gaia Meoni, Chiara Vergata, Federico Martinelli, Elie Maza, Anis Djari, Julien Pirrello, Beatrice Pezzarossa, Fernando Malorgio, Pietro Tonutti
Summary: This study investigated the effects of enriching tomatoes with selenium during the last stages of fruit development, particularly ripening. Selenium enrichment had no significant effects on ethylene production or color changes in the ripening fruit but influenced the biochemical composition of ripe tomatoes. Selenium decreased beta-carotene content, increased naringenin and chlorogenic acid accumulation, and decreased coumaric acid level. It also affected the volatile organic compound profile, including specific apocarotenoid compounds. RNA-seq analysis showed that selenium treatment mainly impacted gene expression related to hormonal signaling, secondary metabolism, flavonoid biosynthesis, and glycosaminoglycan degradation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Ferdinando Galluzzo, Giulio Visentin, Johannes B. C. H. M. van Kaam, Raffaella Finocchiaro, Stefano Biffani, Angela Costa, Maurizio Marusi, Martino Cassandro
Summary: Gestation length (GL) in Italian Holstein population is controlled by direct and maternal genetic components. The heritability of direct effect is higher than that of maternal effect. Extreme GL selection may have negative consequences on important traits such as milk yield and fertility. It is advisable to select an intermediate GL in Italian Holstein population.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2023)
Article
Agriculture, Dairy & Animal Science
A. Goi, A. Costa, G. Visentin, M. De Marchi
Summary: In this study, mid-infrared spectroscopy was used to successfully predict the concentration of immunoglobulin G (IgG) and traditional components such as protein and fat in colostrum. Mid-infrared spectroscopy can be a rapid and affordable method for large-scale quantification of IgG, protein, lactose, and screening of low-quality samples in colostrum. These findings are important for breeders in defining specific selection strategies and for farmers in management purposes. Additionally, they may have implications for other stakeholders in the animal and human food and pharmaceutical industry where colostrum is an emerging ingredient.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Giovanni Niero, Steffi Anna Thomas, Kassiani Mouratidou, Giulio Visentin, Massimo De Marchi, Mauro Penasa, Martino Cassandro
Summary: The present study evaluated the performance of the radial immunodiffusion (RID) technique for quantifying milk lactoferrin (LF) and investigated the sources of variation in LF concentration in individual milk samples. The RID method showed good repeatability and reproducibility, indicating its suitability as a consistent test for LF quantification. Milk LF was found to be positively associated with somatic cell score and negatively associated with lactose content. Lower LF concentration was observed in milk from healthy and susceptible cows compared to mastitic and chronic cows. Milk LF has the potential to be a useful biomarker for early mastitis detection.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Anton Shiriaev, Stefano Brizzolara, Carlo Sorce, Gaia Meoni, Chiara Vergata, Federico Martinelli, Elie Maza, Anis Djari, Julien Pirrello, Beatrice Pezzarossa, Fernando Malorgio, Pietro Tonutti
Summary: This study investigated the effects of selenium enrichment on tomato ripening and found that selenium had an impact on metabolic processes and the biochemical composition of ripe tomatoes. The changes in metabolites may be due to the influence of selenium treatment on gene expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)