期刊
CARBOHYDRATE POLYMERS
卷 121, 期 -, 页码 132-139出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.12.057
关键词
Hyaluronic acid; Quantum dots; Melphalan; Drug delivery system
资金
- National Natural Science Foundation of China [51473130]
- Innovation Research Fund of Undergraduate Special Project [136620004]
- Research Fund of Innovation Projects for Graduate Students [2014-zy-221]
- National College Students Innovation Programs [20141049720005]
Polymer-drug conjugates have played an important role in improving tumor cell targeting and the selectivity of anticancer drugs. In this study, quantum dots and melphalan were attached to the backbone of hyaluronic acid to synthesize a polymer-drug conjugate. The physicochemical properties of the conjugate were characterized by FT-IR, XRD, H-1 NMR, UV-Vis spectra and DIS. The in vitro drug release profiles and cell evaluation were investigated. The results showed that the conjugate was synthesized and self-assembled into nanoparticles with a diameter of 115 +/- 2.3 nm. The conjugate had a pH-sensitive drug controlled release property. It was an ideal receptor-mediated delivery system and can be internalized into the human breast cancer cell. It had a better inhibition effect on human breast cancer cell and a poorer inhibition effect on normal breast cell than melphalan. These results supported that the conjugate would be a promising candidate for cancer therapy. (C) 2014 Elsevier Ltd. All rights reserved.
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