Article
Biochemistry & Molecular Biology
Kun Wang, Jingchen Sun, Jing Zhao, Yongjiao Gao, Di Yao, Daqing Sun, Mengdie Tai, Yuxi Pan, Yanjie Wang, Baoxin Lu, Feng Zuo
Summary: In this study, a capsular polysaccharide CPS-2 was isolated from Lactobacillus fermentum GBJ and characterized. CPS-2 exhibited immunomodulatory effects and anti-aging properties, making it a potential ingredient in the food or pharmaceutical industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agricultural Engineering
Xianxiang Chen, Shihua Wu, Rong Huang, Xuan Liu, Mingyue Shen, Jianhua Xie
Summary: The underlying mechanisms of the immunomodulatory effect of sulfated modifications of Chinese yam polysaccharide (S-CYP) were studied using RNA sequencing and a co-culture model. The results showed that S-CYP can activate and mature RAW264.7 cells and indirectly affect their immune function by increasing cytokine secretion. These findings provide a theoretical basis for exploring S-CYP as an immunomodulatory agent.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Microbiology
Yaoqin Hong, Jilong Qin, Xavier Bertran Forga, Makrina Totsika
Summary: Capsular polysaccharides protect pathogenic bacteria and have diverse genetic clusters. Through genetic analysis of E. coli sequences, seven new gene clusters were identified, revealing unexpected capsular diversity. The diversity is due to recombination events and plasmid transfer between Enterobacteriaceae species. The study highlights the need to monitor the evolutionary dynamics of capsules in pathogenic E. coli for effective phage therapy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Food Science & Technology
Ruoxin Chen, Jingxiang Xu, Weihao Wu, Yuxi Wen, Suyue Lu, Hesham R. El-Seedi, Chao Zhao
Summary: This review explores the structure-activity relationship of polysaccharides, highlighting the contributions of molecular weight, monosaccharide composition, functional groups, types of glycoside bonds, conformation, and branching degrees to immunostimulatory activity. However, the limited purity and heterogeneity of polysaccharides pose challenges to studying their structure-activity relationships.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lei Yuan, Zheng-Chang Zhong, Yu Liu, Hong Quan, Ya-Zhou Lu, Er-Hao Zhang, Hao Cai, Lian-Qiang Li, Xiao-Zhong Lan
Summary: SPS-1, a galactose- and arabinose-rich polysaccharide from Sambucus adnata, functions as an immunomodulator by activating MAPKs-related proteins, increasing the expression levels of nuclear transcription factors, and enhancing macrophage phagocytosis, ultimately stimulating immune response. This suggests that SPS-1 has the potential to be a drug for immunological diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Linlin Huang, Jing Zhao, Yunlu Wei, Guoyong Yu, Fei Li, Quanhong Li
Summary: CMDP-4b, a pectic polysaccharide extracted from Cucurbita moschata Duch, possesses immunomodulatory activity by inducing nitrous oxide and cytokine secretion, as well as promoting macrophage activity through the NFκB and MAPKs signaling pathways. Toll-like receptor 4 and complement receptor 3 may play a critical role in CMDP-4b-induced macrophage activation.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Biomaterials
Hamilton Kakwere, Rian Harriman, Mauricio Pirir, Crystal Avila, Kristen Chan, Jamal S. Lewis
Summary: This study demonstrates the synthesis of immunologically active polymer-carbohydrate conjugates and nanoparticles using a capsule zwitterionic polysaccharide (CZP) derived from commensal gut bacteria. The purified CZP was modified and conjugated with polymers or antigens using click chemistry reactions, and the resulting conjugates were fabricated into nanoparticles. The conjugates and nanoparticles showed immunological activity by activating toll-like receptor 2 (TLR2) and inducing cytokine production. This work provides a chemical biology strategy for generating immunomodulatory nanomaterials, which have potential applications as vaccines or immunotherapeutics.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemistry & Molecular Biology
Linlin Huang, Jing Zhao, Yunlu Wei, Guoyong Yu, Quanhong Li
Summary: A neutral polysaccharide CMDP-1a was isolated from pumpkin, with a determined structure of alpha-1,4 linked glucopyranosyl residues. This polysaccharide showed potential immunomodulatory effects and could be used as a food immunomodulator.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Bao Yu, Dan Zhang, Yingqin Wu, Wei Tao, Quji Luorong, Juan Luo, Lihong Tan, Huan Chen, Weiguo Cao
Summary: In this study, a novel acidic polysaccharide (HTP-1) was extracted from mature Hawk tea leaves. HTP-1 showed significant immunoregulatory activities by alleviating jejunum injury and improving immune organ indexes, cytokines, and immunoglobulins in immunosuppressed mice. Furthermore, HTP-1 supplementation altered the intestinal microbiota composition and increased the abundances of beneficial bacteria, indicating a regulatory role on gut microbiota and potential as functional foods.
Article
Pharmacology & Pharmacy
Wuxia Zhang, Yihua Hu, Jiaqi He, Dongdong Guo, Jinzhong Zhao, Peng Li
Summary: A novel polysaccharide (LHPW) was extracted from Lycopi Herba and shown to have potential immunomodulatory activity, activating macrophages and promoting splenocyte proliferation in experimental tests. This study sheds light on the immunomodulatory properties of Lycopi Herba through the discovery of a new polysaccharide.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Maxim S. Kokoulin, Elena N. Sigida, Alexandra S. Kuzmich, Ibrahim M. Ibrahim, Yulia P. Fedonenko, Svetlana A. Konnova
Summary: The structure and activity of capsular polysaccharides isolated from Halomonas aquamarina EG27S8QL and Cobetia pacifica KMM3878 were investigated. The polysaccharides were found to be structurally related sulfated galactans. The CPS from H. aquamarina EG27S8QL had not been reported previously, while the CPS from C. pacifica KMM3878 was identical to the previously studied O-polysaccharide. Both CPS exhibited an anti-proliferative effect and suppressed colony formation of DLD-1 and MCF-7 cells in different ways.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Xiaolong Yang, Siqing Wei, Xiaoming Lu, Xuguang Qiao, Jesus Simal-Gandara, Esra Capanoglu, Lukasz Wozniak, Liang Zou, Hui Cao, Jianbo Xiao, Xiaozhen Tang, Ningyang Li
Summary: A neutral ginger polysaccharide fraction (NGP) isolated from ginger was found to have a low molecular weight primarily consisting of glucose, with immunomodulatory activity on RAW264.7 cells. NGP could enhance macrophage proliferation, increase immune substance production, and potentially serve as an immune agent.
Article
Nutrition & Dietetics
Dongshuai Qu, Shuaitao Lian, Hongjie Hu, Wenjing Sun, Hongbin Si
Summary: This study elucidates the physicochemical properties and immunomodulatory activity of two polysaccharides (ACP(t0) and ACP(t2)) from Abrus cantoniensis. The results demonstrate that ACP(t0) and ACP(t2) exhibit immunomodulatory activity by promoting cell proliferation, enhancing phagocytosis, and releasing immune molecules. Moreover, they activate specific signaling pathways to exert immunomodulatory effects. ACP(t2) shows higher immunomodulatory activity than ACP(t0), suggesting its potential application in the food and pharmaceutical industries.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Fengwei Ma, Hongbing Liu, Su Xu, Yongyou Cheng, Qiang Fei, Haijiang Chen
Summary: A water-soluble acidic polysaccharide (LCP-05) was isolated from Leucosceptrum canum Smith with a molecular weight of approximately 8.9 kDa. LCP-05 is composed of Man, Rha, GlcA, GalA, Glc, Gal and Ara. It has been found to significantly induce the production of NO, IL-6, and TNF-alpha in RAW264.7 cells, as well as have a suppressive effect on cell growth and migration of mammary breast cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Applied
Wenjing Lu, Zhifeng Yang, Juan Chen, Di Wang, Yu Zhang
Summary: This review highlights the antiviral mechanisms of sulfated polysaccharides, suggesting that they may interfere with various steps in the virus life cycle or enhance host immune response. Additionally, the antiviral activity of sulfated polysaccharides is influenced by factors such as degree of substitution, substitution position, molecular weight, and spatial conformation, providing insights for the development of novel therapeutic agents.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)