Article
Biology
Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Emi Aizawa, Yoshiko Mizushina, Sachiko Watanabe, Chintogtokh Baatarjav, Takayoshi Matsumura, Masafumi Takahashi
Summary: CAPS is an autoinflammatory syndrome caused by mutations of the NLRP3 gene, and mutated NLRP3 can form cryo-sensitive aggregates to promote inflammasome assembly, with IL-1β release influenced by mutated NLRP3 and Ca2+ playing a crucial role in inflammasome assembly.
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ru Li, Mousumi Beto Mukherjee, Jun Lin
Summary: In this review, the effects of cytokines and chemokines on myeloid-derived suppressor cells in cancer metastasis are summarized. Cytokines and chemokines in the tumor microenvironment alter the functional properties of MDSCs and are involved in their production, infiltration, and immunosuppressive functions. The manipulation of MDSCs by tumors through cytokine and chemokine signaling is discussed, as well as potential treatment strategies targeting these signaling pathways to combat the immunosuppressive activities of MDSCs and improve disease outcomes.
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Julien Stackowicz, Nicolas Gaudenzio, Nadine Serhan, Eva Conde, Ophelie Godon, Thomas Marichal, Philipp Starkl, Bianca Balbino, Axel Roers, Pierre Bruhns, Friederike Jonsson, Philippe Moguelet, Sophie Georgin-Lavialle, Lori Broderick, Hal M. Hoffman, Stephen J. Galli, Laurent L. Reber
Summary: Gain-of-function mutations in NLRP3 gene cause CAPS, with neutrophils potentially being the main cellular drivers of CAPS pathology.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Immunology
Vikas Duhan, Mark J. Smyth
Summary: Cancer immunotherapies are increasingly approved in the clinic, but only a fraction of patients benefit long-term. Understanding the mechanisms of immunotherapeutic resistance is critical for broader utility and benefit of cancer immunotherapy. Tumor infiltrating myeloid cells play a critical role in regulating anti-tumor lymphocyte effector cells in the tumor microenvironment.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Allergy
Katerina Theodoropoulou, Lotte Spel, Lea Zaffalon, Maeva Delacretaz, Michael Hofer, Fabio Martinon
Summary: This study investigates the mutations in NLRP3 gene and its regulation on inflammatory responses in a rare autoinflammatory disease called CAPS. The researchers discovered various splice variants of NLRP3 and found that some of them may regulate NLRP3 activation through alternative splicing. They also observed the importance of different coding exons in the LRR domain for inflammasome function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jie Zhao, Yiting Dong, Yundi Zhang, Jie Wang, Zhijie Wang
Summary: This article systematically reviews the complex functions of tumor-associated myeloid cells (TAMCs) in tumor development and immune response, and summarizes clinical strategies to overcome resistance to immunotherapy and future research prospects.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Haomin Yan, Tomohiro Kawano, Hideaki Kanki, Kumiko Nishiyama, Munehisa Shimamura, Hideki Mochizuki, Tsutomu Sasaki
Summary: In this study, prophylactic anti-Ly6G antibody administration was found to have a protective effect against ischemic stroke by reducing activated neutrophil infiltration and neutrophil extracellular trap formation in the brain parenchyma, as well as suppressing polymorphonuclear myeloid-derived suppressor cell accumulation. This study may provide a novel therapeutic approach for ischemic stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Immunology
Alexander Glover, Zhaoqin Zhang, Claire Shannon-Lowe
Summary: Myeloid derived suppressor cells (MDSCs) are a heterogenous population of myeloid cells derived from monocyte and granulocyte precursors. They are pathologically expanded in conditions of ongoing inflammation where they function to suppress both innate and adaptive immunity. They are associated with inhibition of the anti-tumour immune response in cancer and are universally associated with a poor prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Man Liu, Hongxia Zhang, Lu Zhang, Xin Liu, Simin Zhou, Xiaoyi Wang, Weilong Zhong, Jie Zhang, Bangmao Wang, Jingwen Zhao, Lu Zhou
Summary: The study found that increased expression and activation of RIP3 in livers of autoimmune hepatitis patients and animal models, and inhibition of RIP3 kinase prevented immune-mediated hepatitis by promoting MDSCs infiltration with immunoregulatory properties. This indicates that RIP3 blockade may be a novel avenue for autoimmune hepatitis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Yin Celeste Cheuk, Shihao Xu, Dong Zhu, Yongsheng Luo, Tian Chen, Juntao Chen, Jiawei Li, Yi Shi, Yi Zhang, Ruiming Rong
Summary: The supernatant derived from myeloid-derived suppressor cells (MDSCs) inhibits the transforming growth factor beta 1 (TGF-beta 1)-induced myofibroblastic differentiation of mesenchymal stem cells (MSCs) through IL-15. This finding provides a new perspective for the development of treatment strategies for renal fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Leonardo Oliveira Mendonca, Myrthes Anna Maragna Toledo-Barros, Vinicius Nunes Cordeiro Leal, Mariela Estefany Gislene Vera Roa, Raylane Adrielle Goncalves Cambui, Eliana Toledo, Samar Freschi Barros, Amanda Melato de Oliveira, Maria Cecilia Rivitti-Machado, Isadora Carvalho Medeiros Francescantonio, Anete Sevciovic Grumach, Norma de Oliveira Penido, Fabio Fernandes Morato Castro, Jorge Kalil, Alessandra Pontillo
Summary: This study reports a five-year experience on the use of NLRP3 inflammasome functional assays in the differential diagnosis of Brazilian patients with a clinical suspicion of CAPS. The results show that the NLRP3 functional assay can assist in the clinical diagnosis of CAPS, even in patients with unknown genetic defects.
CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Minjie Luo, Hao Wang, Ke Liu, Meidong Liu, Sipin Tan, Yaxi Zhu, Huali Zhang
Summary: This study demonstrates that blockade of IL-1R1 has a protective effect on liver injury in septic mice. Anakinra treatment and IL-1R1 deficiency inhibit the migration of MDSCs to the liver in sepsis, attenuating the immune suppression of MDSCs on effector T cells. Furthermore, IL-1R1 blockade promotes the switch from pro-inflammatory M1 macrophage to anti-inflammatory M2 phenotype and enhances bacterial clearance in the liver, contributing to the attenuation of liver injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Fengqing Hou, Lianci Peng, Jiali Jiang, Tingting Chen, Dongyi Xu, Qingyuan Huang, Chao Ye, Yuanyi Peng, Dong-Liang Hu, Rendong Fang
Summary: Staphylococcus aureus is an important zoonotic food-borne pathogen that can cause severe infections. A study found that the enterotoxin O of S. aureus can induce interleukin-1 beta secretion in mouse neutrophils, which is dependent on the activation of TLR4/JNK/NLRP3 inflammasome signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Alexander Buia, Sibel Oguz, Annette Lehn, Eva Herrmann, Ernst Hanisch
Summary: The study aimed to investigate whether the use of 3D visualization could reduce postoperative complications in a real-world setting. The results showed no significant difference between the 3D and 2D groups in terms of overall complications and operation time.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Infectious Diseases
Gundolf Schuettfort, Ana Groh, Gerrit Kann, Annette Haberl, Eva Herrmann, Nils Wetzstein, Maria Johanna Gobertina Tetuanui Vehreschild, Christoph Stephan
Summary: After the coverage of PrEP costs by German SHI, there was a tendency for an increased ratio of STIs in people living with HIV, particularly syphilis and infections caused by Chlamydia trachomatis.
Article
Infectious Diseases
Nils Wetzstein, Alena-Pauline Drummer, Annabelle Bockey, Eva Herrmann, Claus Philippe Kuepper-Tetzel, Christiana Graf, Benjamin Koch, Udo Goetsch, Maria J. G. T. Vehreschild, Lorenzo Guglielmetti, Berit Lange, Thomas A. Wichelhaus, Christoph Stephan
Summary: Geographical origin is a predictor for the occurrence of extrapulmonary TB, which is associated with delayed diagnosis, specific virulence factors of MTB, and relevant comorbidities.
Article
Infectious Diseases
Martin Heller, Clara Henrici, Judith Buettner, Sebastian Leube, Isabelle Treske, Petra Pospischil, Michael Doll, Ilka Schanz, Agnes Hallier, Eva Herrmann, Michael Schmidt, Christoph Sarrazin
Summary: This early retrospective cohort study analyzed the reduction of viral load and clinical symptoms in 26 patients with SARS-CoV-2 treated with bamlanivimab or casirivimab/imdevimab. The results showed a faster decline in viral load, milder symptoms, and reduced severity of COVID-19 in the intervention groups.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Aissa Miriam Roehrig, Katja Jakobi, Julia Dietz, Dominique Thomas, Eva Herrmann, Christoph Welsch, Christoph Sarrazin, Josef Pfeilschifter, Stefan Zeuzem, Georgios Grammatikos
Summary: The serum concentration of sphingolipids, especially sphingosine, sphinganine, and their derivatives S1P and SA1P, along with glucosylceramides, can predict the failure of DAA treatment in chronic HCV patients. These sphingolipids could serve as additional biomarkers to guide treatment strategies aiming to eliminate HCV infection.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Clinical Neurology
Sae-Yeon Won, Johannes Walter, Silvia Hernandez-Duran, Obada T. Alhalabi, Bedjan Behmanesh, Joshua D. Bernstock, Marcus Czabanka, Nazife Dinc, Daniel Dubinski, Charlotte Flueh, Thomas M. Freiman, Anne S. Grosch, Eva Herrmann, Young Sill Kang, Juergen Konczalla, Andreas Kramer, Felix Lehmann, Johannes Lemcke, Ruzanna Melkonian, Dorothee Mielke, Lukas Mueller, Florian Ringel, Veit Rohde, Matthias Schneider, Christian Senft, Patrick Schuss, Merih Oznur Turgut, Michael Synowitz, Joana M. Ullmann, Hartmut Vatter, Klaus Zweckberger, Fatma Kilinc, Florian Gessler
Summary: This study aims to validate the ICH and ICH-GS scores in patients with cerebellar hemorrhage and compare the outcomes of surgical management with conservative treatment. The results showed that both ICH and ICH-GS scores have good prognostic accuracy for overall mortality and functional outcomes. Surgical management was beneficial for patients with severe cerebellar hemorrhages, indicated by high ICH scores, while conservative treatment was reasonable for patients with lower ICH scores. Therefore, ICH and ICH-GS scores are useful tools for predicting survival and outcome in cerebellar ICH patients.
Article
Gastroenterology & Hepatology
Johanes Hausmann, Foteini Lefa, Natalie Filmann, Axel Eickhoff, Stefan Zeuzem, Eva Herrmann, Marcel Tantau, Joerg Albert
Summary: In endoscopic retrograde cholangiopancreatography (ERCP), guidewires with an angled tip showed higher success rates compared to those with a straight tip, particularly in treating intrahepatic strictures. There were no differences in success rates between guidewires with standard and enhanced tip flexibility in all indications.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Anastasia Boss, Eva Herrmann, Yves Gramlich, Alexander Klug, Oliver Neun, Sebastian Manegold, Reinhard Hoffmann, Sebastian Fischer
Summary: The Weil osteotomy is commonly performed for chronic metatarsalgia, and screw fixation is historically used for metatarsal head refixation. However, this study suggests that screw fixation is not always necessary. Retrospective analysis of 155 patients with 278 Weil osteotomies demonstrated a lower revision rate in patients without screw fixation. Therefore, regular screw fixation after a Weil osteotomy may not be justified based on the available data.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Olivia Ott, Eva Herrmann, Annabel Schulz, Edelgard Lindhoff-Last
Summary: This prospective non-interventional trial included 82 patients with thromboembolic antiphospholipid syndrome (APS) and assessed the effect of COVID-19 infections and/or COVID-19 vaccinations on antiphospholipid antibodies (aPL). The study found no increase in aPL in the total study population, with slight decreases observed for certain antibodies and slight increases observed only in patients with COVID-19 infection and vaccination. The low recurrence rate of thrombotic events in these patients may be attributed to high vaccination rates and effective anticoagulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Xinji Tan, Georg Jung, Eva Herrmann, Wojciech Derwich, Reinhart Grundmann, Thomas Schmitz-Rixen, Daphne Gray
Summary: Although female patients have a lower prevalence of abdominal aortic aneurysm (AAA), they seem to have a worse treatment outcome compared with male patients. Both maximum aneurysm diameter and aortic size index (ASI) are important indicators of the risk of AAA rupture, among which ASI has been shown capable of equalizing sex-related anatomical differences.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Rebecca Sell, Magalie Meinert, Eva Herrmann, Yves Gramlich, Alexander Klug, Oliver Neun, Reinhard Hoffmann, Sebastian Fischer
Summary: Posttraumatic osteoarthritis may require surgical fusion of the ankle joint if non-surgical therapy is unsuccessful. The decision to perform fusion is based on the patient's pain and disability, radiographic imaging, and surgeon experience, without strict guidelines. This study compared outcomes of tibiotalocalcaneal arthrodesis (TTCA) and tibiotalar arthrodesis (TTA) to highlight the importance of the subtalar joint. The results showed significantly worse clinical scores in the TTCA group compared to the TTA group, indicating the need for careful consideration of generous subtalar joint fusion with planned ankle arthrodesis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Christiana Graf, Inken Wagener, Katharina Grikscheit, Sebastian Hoehl, Annemarie Berger, Nils Wetzstein, Julia Dietz, Georg Dultz, Florian Michael, Natalie Filmann, Eva Herrmann, Peter Tinnemann, Udo Goetsch, Sandra Ciesek
Summary: This study found that olfactory dysfunction is common in patients with both positive and negative COVID-19 tests, but its diagnostic accuracy is not high enough to be used as an early identification tool for COVID-19 infection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Magalie Meinert, Christian Colcuc, Eva Herrmann, Johannes Harbering, Yves Gramlich, Marc Blank, Reinhard Hoffmann, Sebastian Fischer
Summary: Joint destruction necessitates tibiotalocalcaneal arthrodesis (TTCA) in cases of clinical deficits that cannot be controlled conservatively, possibly leading to sepsis. We aimed to compare the underlying etiology of posttraumatic joint destruction and the outcomes after TTCA in patients with a septic or aseptic history. The significantly worse results of S-TTCA compared to A-TTCA show the long and stressful ordeal that patients with a septic history suffer. Further attention must be paid to infection prophylaxis and, if necessary, early infection revision.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Marie O. von Gehren, Stefan Ruettermann, Georgios E. Romanos, Eva Herrmann, Susanne Gerhardt-Szep
Summary: The purpose of this study was to observe the quality of posterior composite restorations after more than 23 years of service. A total of 22 patients with 42 restorations underwent two follow-up examinations. Results showed significantly worse scores for six out of seven criteria at the second follow-up evaluation. The study suggests the need for further research with extended follow-up time and regular assessments.
Article
Anesthesiology
Patrick Meybohm, Elke Schmitt, Suma Choorapoikayil, Lotta Hof, Oliver Old, Markus M. Mueller, Christof Geisen, Erhard Seifried, Olaf Baumhove, Samuel de Leeuw van Weenen, Alexandra Bayer, Patrick Friederich, Brigitte Braeutigam, Jens Friedrich, Matthias Gruenewald, Gunnar Elke, Gerd P. Molter, Diana Narita, Ansgar Raadts, Christoph Haas, Klaus Schwendner, Andrea U. Steinbicker, Dana J. Jenke, Josef Thoma, Viola Weber, Markus Velten, Maria Wittmann, Henry Weigt, Bjoern Lange, Eva Herrmann, Kai Zacharowski
Summary: By implementing Patient Blood Management (PBM) program, there was a significant reduction in red blood cell transfusion and the safety of PBM was demonstrated in a study of over 1 million surgical patients.
BRITISH JOURNAL OF ANAESTHESIA
(2023)