期刊
JOURNAL OF INFECTIOUS DISEASES
卷 214, 期 1, 页码 161-165出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw095
关键词
dilated; cardiomyopathy; Chagas disease; lncRNA; MIAT; biomarker
资金
- Institut National de la Sante et de la Recherche Medicale, Aix-Marseille University (Direction des Relations Internationales)
- USP-COFECUB program
- ARCUS II PACA Bresil program
- Brazilian National Research Council
- Sao Paulo State Research Funding Agency (FAPESP)
- French National Research Agency
- FAPESP
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据