期刊
JOURNAL OF INFECTIOUS DISEASES
卷 215, 期 1, 页码 114-121出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiw506
关键词
CD163; CD14; women; HIV infection; cognition disorders; intesticial fatty acid-binding protein (1-19)
资金
- National Institutes of Health [K24-MH-098759]
- National Institute of Allergy and Infectious Diseases [UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590, K24 AI 108516]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [UO1-HD-32632]
- National Cancer Institute
- National Institute on Drug Abuse
- National Institute on Deafness and Other Communication Disorders
- National Center for Research Resources (UCSF-CTSI grant) [UL1 RR024131]
- National Institute of Mental Health [K01-MH-098798]
Background. Cognitive impairment persists despite suppression of plasma human immunodeficiency virus (HIV) RNA. Monocyte-related immune activation is a likely mechanism. We examined immune activation and cognition in a cohort of HIV-infected and uninfected women from the Women's Interagency HIV Study (WIHS). Methods. Blood levels of activation markers, soluble CD163 (sCD163), soluble CD14 (sCD14), CRP, IL-6, and a gut microbial translocation marker (intestinal fatty acid binding protein (I-FABP)) were measured in 253 women (73% HIV-infected). Markers were compared to concurrent (within +/- one semiannual visit) neuropsychological testing performance. Results. Higher sCD163 levels were associated with worse overall performance and worse verbal learning, verbal memory, executive function, psychomotor speed, and fine motor skills (P <.05 for all comparisons). Higher sCD14 levels were associated with worse verbal learning, verbal memory, executive function, and psychomotor speed (P <.05 for all comparisons). Among women with virological suppression, sCD163 remained associated with overall performance, verbal memory, psychomotor speed, and fine motor skills, and sCD164 remained associated with executive function (P <.05 for all comparisons). CRP, IL-6, and I-FABP were not associated with worse cognitive performance. Conclusions. Monocyte activation was associated with worse cognitive performance, and associations persisted despite viral suppression. Persistent inflammatory mechanisms related to monocytes correlate to clinically pertinent brain outcomes.
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