Article
Biotechnology & Applied Microbiology
Gen Li, Yin Zhang, Jiezhou Wu, Renhao Yang, Qi Sun, Yidong Xu, Bo Wang, Ming Cai, Yang Xu, Chengyu Zhuang, Lei Wang
Summary: This study explores the effects and mechanism of adipose stem cells-derived exosomes (ADSCs-Exos) and ADSCs-Exos modified tissue engineering scaffold on bone defect repair. The results demonstrate that ADSCs-Exos promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and ADSCs-Exos modified scaffold enhances the repair of BMSCs and bone defects both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Antoine Karoichan, Timothee Baudequin, Hadil Al-Jallad, Maryam Tabrizian
Summary: A rapidly gelling, injectable chitosan sponge was proposed as a potential candidate for delivering adipose tissue-derived mesenchymal stem cells, showing high encapsulation efficiency and cell viability. The scaffold also exhibited potential for bone tissue engineering, with the ability to differentiate encapsulated cells into the osteogenic lineage and improve mineralization levels through co-encapsulation of pyrophosphatase.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell & Tissue Engineering
Stefano Negri, Yiyun Wang, Takashi Sono, Qizhi Qin, Ginny Ching-Yun Hsu, Masnsen Cherief, Jiajia Xu, Seungyong Lee, Robert J. Tower, Victoria Yu, Abhi Piplani, Carolyn A. Meyers, Kristen Broderick, Min Lee, Aaron W. James
Summary: Research has shown that anti-DKK1 neutralizing antibodies can enhance the osteogenic differentiation of human adipose-derived stem cells, aiding in bone repair, and demonstrating potential beneficial effects in a mouse model.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Engineering, Biomedical
Yiting Lou, Huiming Wang, Guanchen Ye, Yongzheng Li, Chao Liu, Mengfei Yu, Binbin Ying
Summary: This review discusses the important role of periosteum in bone defect repair and regeneration, as well as the need for developing tissue-engineered periosteum (TEP). The construction strategies for TEP are explored from the perspectives of materials, mechanical properties, cell-based strategies, and combination with growth factors. Current challenges and future perspectives for TEP development are also discussed.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Mei-Ling Ho, Chin-Jung Hsu, Che-Wei Wu, Ling-Hua Chang, Jhen-Wei Chen, Chung-Hwan Chen, Kui-Chou Huang, Je-Ken Chang, Shun-Cheng Wu, Pei-Lin Shao
Summary: This study investigated the effect of adipose-derived stem cell (ADSC)-secreted extracellular vesicles (EVs) on osteoblast function. The results showed that ADSC-EVs can enhance osteoblast proliferation and activity, and may regulate osteoblast function through autophagy or signaling pathways.
Review
Cell Biology
Sadia Farhana, Yew Chun Kai, Ramlah Kadir, Wan Azman Wan Sulaiman, Nor Asyikin Nordin, Nur Azida Mohd Nasir
Summary: In recent years, utilizing adipose tissue and adipose-derived stem cells (ADSCs) has become a promising field of allograft. The therapeutic potential of adipose tissue and ADSCs lies in their molecular secretions, multi-differentiation and self-renewal abilities. However, understanding the existing functional capacity of adipose tissue and ADSCs in allograft is crucial to address the safety concerns due to interactions between tumor microenvironment and ADSCs. Comprehensive immunomodulatory analysis is needed to ensure successful allograft of adipose tissue and ADSCs, avoiding oncological risks.
CELL AND TISSUE RESEARCH
(2023)
Article
Polymer Science
Banafsheh Safari, Marziyeh Aghazadeh, Leila Roshangar, Ayuob Aghanejad, Soodabeh Davaran
Summary: This study reports the fabrication and evaluation of a bioactive hybrid scaffold collagen/P-PCL for bone tissue engineering. The scaffold showed biocompatibility, osteoconductivity, and osteoinductivity, supporting the proliferation and differentiation of AD-MSCs.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Engineering, Biomedical
Jinsong Wang, Guobao Chen, Zhong M. Chen, Fu P. Wang, Bin Xia
Summary: The role of periosteum in the treatment of bone defects has been gradually discovered, but there are still challenges due to limited transplantable periosteum. Biomimetic periosteal scaffolds that mimic the composition and structure of natural periosteum have emerged. This article reviews the current preparation methods of biomimetic periosteal scaffolds based on various biomaterials, providing a systematic perspective for future preparation.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Biophysics
Peng Liu, Tiecheng Qiu, Jiabing Liu, Xiaoxi Long, Xianwei Wang, Hemin Nie, Mengqiang Yu, Chao Ma, Nan Lin, Swee Hin Teoh, Zuyong Wang
Summary: Researchers have developed a biomimetic film with the potential to be used as a synthetic periosteum. This film, made of a blend of poly(epsilon-caprolactone) and microtantalum particles, shows enhanced surface wettability and mechanical strength. It also promotes cell proliferation, alignment, and osteogenic enhancement.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
R. Tevlin, H. desJardins-Park, J. Huber, S. E. DiIorio, M. T. Longaker, D. C. Wan
Summary: Osteoarthritis is a global burden that affects joints and bones. Tissue engineering, specifically adipose-derived stromal cells, shows promise as a treatment option. Advancements in material science allow for improved engraftment of these cells and activation of biophysical signals through designed microstructures.
Article
Medicine, Research & Experimental
Yamini Chandramohan, Kavya Jeganathan, Sanjana Sivanesan, Pavani Koka, Trikkur Madom Seetaraman Amritha, Selvaraj Vimalraj, Anuradha Dhanasekaran
Summary: This study successfully isolated mesenchymal stem cells (MSCs) from human Ovarian Follicular Fluid (OFF) for the first time, and characterized them through various methods. The growth of MSCs with the conditioned medium obtained from a biocomposite scaffold promoted osteoblast differentiation, indicating good culture conditions and applicability.
Article
Biochemistry & Molecular Biology
Yiqiang Chang, Ansong Ping, Chunyu Chang, Volker M. Betz, Lin Cai, Bin Ren
Summary: This study investigated the effects of lactoferrin (LF) on the osteogenic differentiation of adipose-derived stem cells (ADSCs). The results showed that LF could promote the proliferation and osteogenic differentiation of ADSCs. LF concentration of 100 mu g/mL exhibited the most significant osteoinductive effect. LF could be used as an alternative to bone morphogenetic protein-2 (BMP-2) in bone tissue engineering to promote bone repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Danli Zhu, Wanting Bao, Boxuan Wei, Hao Wei, Jinwu Wang, Guangdong Zhou, Xiansong Wang, Shanyu Guo
Summary: In this study, a strategy for the construction of vascularized tissue-engineered adipose tissue was proposed. By integrating a gas-foamed method (soil) and three-dimensional cell spheroids (seeds), adipose tissue regeneration was achieved. The prepared soil significantly enhanced the vascularization of the regenerated tissue, while optimizing the seed cells promoted adipogenesis. This study provides a solution for the regeneration of vascularized adipose tissue and establishes a general research model for the reconstruction of breast defects.
APPLIED MATERIALS TODAY
(2023)
Article
Biochemistry & Molecular Biology
Federica Grilli, Ennio Albanesi, Beatriz Pelacho, Felipe Prosper, Paolo Decuzzi, Daniele Di Mascolo
Summary: Depositing stem cells at the injury site is a clinically relevant strategy for tissue repair and angiogenesis, but insufficient cell engraftment and survival requires the development of new scaffolds. In this study, a microstructured poly(lactic-co-glycolic acid) (PLGA) fabric was investigated as a promising biodegradable scaffold for adipose-derived stem cell (ADSC) tissue integration. The results showed that ADSCs reassembled into spheroidal-like structures on the PLGA fabric, preserving cell viability and promoting a nonlinear actin organization. Moreover, the secretion of specific factors involved in angiogenesis, extracellular matrix remodeling, and stem cell homing was enhanced on the PLGA fabric compared to conventional substrates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lara Milian, Pilar Molina, Maria Oliver-Ferrandiz, Carlos Fernandez-Sellers, Ana Monzo, Rafael Sanchez-Sanchez, Aitana Braza-Boils, Manuel Mata, Esther Zorio
Summary: This study found the feasibility of isolating and characterizing adipose-derived stem cells (ADSCs) from cadaveric samples, and confirmed their ability to differentiate into chondrocytes and osteocytes. This discovery provides potential applications in tissue engineering and research fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Otavio A. Silva, Michelly G. Pella, Ketul C. Popat, Matt J. Kipper, Adley F. Rubira, Alessandro F. Martins, Heveline D. M. Follmann, Rafael Silva
Summary: This study presents a simple and effective method to prepare cell-compatible drug nanocarriers using human hair as a sustainable keratin source. The extracted rod-shaped keratin nanoparticles (KNPs) demonstrated improved properties compared to KNPs prepared using alkaline methods. They exhibited cytocompatibility towards adipose mesenchymal stem cells and healthy cells, and were found to be a suitable carrier for the anticancer drug berberine. The photothermal properties of the KNPs enhanced the drug release and cytotoxicity against colon adenocarcinoma cells.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Engineering, Chemical
Debora P. Facchi, Suelen P. Facchi, Paulo R. Souza, Elton G. Bonafe, Ketul C. Popat, Matt J. Kipper, Alessandro F. Martins
Summary: Ecovio (R) is a hydrophobic and biodegradable synthetic polymer blend that can be electrospun with the addition of Tween 20 and a chloroform/formic acid mixture. The resulting fibers have thin diameters and improved electrical conductivity and viscosity. The addition of Tween 20 also makes the fibers wettable and capable of adsorbing silver ions, enhancing their antimicrobial properties. The biodegradable composite filter made from Ecovio (R)/Tween 20 fibers can effectively remove bacteria from water.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Evandro Bonifacio, Debora P. Facchi, Paulo R. Souza, Johny P. Monteiro, Ketul C. Popat, Matt J. Kipper, Alessandro F. Martins
Summary: This study presents an innovative adsorbent material obtained through dialysis and freezing-thawing cycles, resulting in a solid adsorbent with water insolubility and stability. The adsorbent showed high efficiency in removing dyes from water and exhibited favorable kinetic and equilibrium properties. The adsorption process was spontaneous, endothermic, and governed by hydrophobic interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Yaowei Guo, Jin Liu, Qinglin Tang, Cuicui Li, Yanying Zhang, Yao Wang, Yanxin Wang, Yupeng Bi, Christopher D. Snow, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang
Summary: The article introduces a new technology for the sensitive detection of the anticancer drug irinotecan using lanthanide-loaded nano-aggregates. The technology shows high sensitivity and selectivity, and can be safely used for detection in both cellular and intracellular environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Longlong Li, Jin Liu, Qian Wang, Yao Wang, Wenfei Shen, Jiuxing Wang, Yanxin Wang, Matt J. Kipper, Haijiao Xie, Laurence A. Belfiore, Jianguo Tang
Summary: In this study, a novel water-soluble, visible-light-excitable, fluorescence enhancement sensor ([Ru(PYPZA-t-BuDO3A)(bipy)2]2+) has been synthesized and characterized. It efficiently recognizes Zn2+ ions without interference from other biologically relevant metal ions, anions, amino acids, small biomolecules, or pharmaceutical molecules. The sensor exhibits high sensitivity for Zn2+ ions and can be applied to sense intracellular Zn2+ in live human cells, with excellent membrane permeability and negligible cytotoxicity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Qian Wang, Longlong Li, Qinglin Tang, Jin Liu, Yao Wang, Jiuxing Wang, Matt J. Kipper, Haijiao Xie, Laurence A. Belfiore, Jianguo Tang
Summary: Luminescent materials with tunable emission properties were achieved by complexation between aluminum (III) ions and 3-hydroxyflavone and 5,7-dichloro-8-hydroxyquinoline ligands. Mixing these two complexes resulted in cyan light emission, which exhibited selective sensitivity to different metal ions.
Article
Materials Science, Multidisciplinary
Jessi R. Vlcek, Liszt Y. C. Madruga, Melissa M. Reynolds, Matt J. Kipper
Summary: Cardiovascular implant surfaces and blood-contacting components of extracorporeal blood circuits can cause blood clot formation and hemolysis. Stable surface coatings that inhibit blood coagulation and hemolysis at the blood-material interface are important for research. Polyelectrolyte multilayer surface coatings (PEMs) can modulate blood-material interactions, and modifying these coatings can improve stability and anticoagulant properties.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Physical
Xianhang Yan, Yanxin Wang, Bingyang Li, Zhenzhen Huang, Zhiyuan Gao, Xinhui Mao, Wei Wang, Zhijun Zhu, Matt J. Kipper, Linjun Huang, Jianguo Tang
Summary: This study reports on a fluorescence probe prepared from rare earth elements for the accurate detection and quantification of Cu2+. The probe is loaded on SiO2 nanoparticles to form a fluorescence nanofiber membrane that can accurately detect Cu2+ through fluorescence quenching.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Applied
Paulo R. Souza, Bruno H. Vilsinski, Ariel C. de Oliveira, Sharise B. R. Berton, Liszt Y. C. Madruga, Henri S. Schrekker, Eduardo Radovanovic, Matt J. Kipper, Alessandro F. Martins, Edvani C. Muniz
Summary: Gelatin and chondroitin sulfate polyelectrolyte multilayers with or without ionic liquids were assembled on oxidized poly(ethylene terephthalate) using the layer-by-layer approach. The introduction of ionic liquids resulted in higher wettability and roughness of the PEM coatings. These coatings showed good antibacterial properties, preventing the attachment and growth of microbial cells.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Chemistry, Multidisciplinary
Siqi Niu, Wenbin Yang, Heng Wei, Michail Danilov, Ihor Rusetskyi, Ketul C. Popat, Yao Wang, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang
Summary: A new photovoltaic device using Ti foil/TiO2 nanotubes and MWCNTs as the photoanode and photosensitizer, respectively, was prepared. The TiO2-NTs and cut-MWCNTs were combined by electrophoresis to form a heterostructure, showing enhanced photocurrent response and efficiency in the photovoltaic device.
Article
Chemistry, Physical
Jin Liu, Yaowei Guo, Yupeng Bi, Yao Wang, Yanxin Wang, Matt J. Kipper, Laurence A. Belfiore, Jianguo Tang
Summary: A new strategy based on Ln(3+) (Eu3+/Tb3+) induced-polyelectrolyte aggregates (LIPAs) is proposed to produce ultraviolet switchable and stable multicolor luminescent patterns for information storage and anti-counterfeiting applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Review
Materials Science, Multidisciplinary
Xinhui Mao, Yanxin Wang, Xianhang Yan, Zhenzhen Huang, Zhiyuan Gao, Yuxuan Wang, Linjun Huang, Matt J. Kipper, Jianguo Tang
Summary: Human activities are generating increasing amounts of oily water, making oil/water separation methods crucial. Membranes and nanofibers with superwetting surfaces offer low cost, high efficiency, and environmental friendliness in oil/water separation. This review discusses various types of superwetting membranes, their structural features, manufacturing technology, applications, and outlines the challenges and future opportunities in the field of oil/water separation.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Zhenzhen Huang, Yanxin Wang, Xianhang Yan, Xinhui Mao, Zhiyuan Gao, Matt J. Kipper, Linjun Huang, Jianguo Tang
Summary: In this study, a luminescent lanthanide complex, Eu(tta)3phen, was used to prepare fluorescent nanofiber films. The nanofibers, composed of chitosan and polyethylene oxide containing silica nanoparticles, encapsulated the Eu(tta)3phen. The resulting Na-CS/PEO-SiO2@Eu(tta)3phen fiber film showed high sensitivity and a wide detection range, making it a recyclable sensor for the detection of Cu2+ ions.
Article
Materials Science, Multidisciplinary
Li-yue Sun, De-hao Yu, Liu Yang, Feng-chun Jia, Zhao-ge Juan, Yao Wang, Yan-xin Wang, Matt J. Kipper, Lin-jun Huang, Jian-guo Tang
Summary: This paper introduces the application of graphene oxide (GO) in membrane separation. Compared with graphene, GO has abundant oxygen-containing functional groups and good mechanical properties and hydophilicity, which makes it widely studied. The paper discusses the separation mechanisms, applications, and methods for tuning the properties of GO membranes, as well as the prospects for future development.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Xianhang Yan, Yanxin Wang, Zhenzhen Huang, Zhiyuan Gao, Xinhui Mao, Matt J. Kipper, Linjun Huang, Jianguo Tang
Summary: In this paper, Janus PAN nanofiber membranes (PNM) were prepared by co blending hydrophilic SiO2 nanoparticles, carbon nanotubes (CNTs) doped with PAN (PNM-SiO2 and PNM-CNT, respectively) and then using sequential multilayer electrospinning. The existence of electrostatic mutual gravitational force between SiO2 and CNTs makes the binding between the multilayer membranes exist more firmly. Janus PAN membranes have different wetting properties and can efficiently separate water-in-oil and oil-in-water emulsions with high flux and separation efficiency.
ACS APPLIED NANO MATERIALS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
