Article
Integrative & Complementary Medicine
Ying Li, Qiong Ouyang, Xu Li, Raphael N. N. Alolgal, Yuanming Fan, Yangyang Sun, Hang Gong, Pingxi Xiao, Gaoxiang Ma
Summary: In this study, the lipid-lowering effects of Gynostemma pentaphyllum (GP) were investigated using a meta-analysis, animal experiments, and metabolomic analysis. The results showed that GP can effectively reduce triglyceride levels and improve blood lipid metabolism by regulating the intestinal microbiota and tryptophan metabolism.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Chemistry, Applied
Hong-Xia Zhang, Zhong-Ze Wang, Zhi-Zhi Du
Summary: This study aimed to elucidate the chemical basis for the sweet property produced by Gynostemma pentaphyllum and discovered sixteen new compounds, with fifteen of them having sweetness intensities 10-100 times higher than sucrose. Gypenoside YN 4 was identified as the sweetest compound, while gypenoside YN 12 had the highest concentration. Structure-activity relationship analysis suggested that sweetness intensity was related to side-chain substitutions or the number of glucosyl groups.
Review
Pharmacology & Pharmacy
Ning Dai, Fang-fang Zhao, Min Fang, Feng-lan Pu, Ling-yao Kong, Jian-ping Liu
Summary: This study evaluated the lipid-lowering effect and safety of Gynostemma pentaphyllum (GP) used alone or as adjunctive therapy for dyslipidemia. The findings suggest that GP has a similar effect as lipid-lowering agents in regulating serum lipids, but is inferior to red yeast rice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin Weng, Yun-Yun Lou, Yun-Shan Wang, Ya-Ping Huang, Jian Zhang, Zhi-Qi Yin, Ke Pan
Summary: Gynostemma pentaphyllum has a long history as a food and dietary supplement in China. Research has found that compounds from G. pentaphyllum can serve as PCSK9 inhibitors and play a role in the treatment of hyperlipidemia.
BIOORGANIC CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Weilin Liao, Imran Khan, Guoxin Huang, Shengshuang Chen, Liang Liu, Wai Kit Leong, Xiao Ang Li, Jianlin Wu, W. L. Wendy Hsiao
Summary: Colorectal cancer ranks the third most common cancer type in both men and women, with disturbed gut microbes potentially contributing to its onset and progression. Maintaining a balanced gut microbiota has become a novel pursuit in the medical field, particularly in gastrointestinal disorders. Gynostemma pentaphyllum saponins have shown prebiotic and cancer-preventive properties through modulation of gut microbiota, with the specific bacteria Bifidobacterium animalis demonstrating anticancer and cancer-preventive activities.
Article
Biochemistry & Molecular Biology
Duc Duy Le, Woohyun Kim, Soohwan Lim, Sun Chang Kim, Giltsu Choi
Summary: Ginsenosides, glycosylated dammarene-type triterpenes found in Panax ginseng and Gynostemma pentaphyllum, share common UGT families for biosynthesis despite belonging to different subfamilies, indicating independent evolutionary selection for their synthesis.
Article
Plant Sciences
Yunyi Zhou, Lixiang Yao, Xueyan Huang, Ying Li, Chunli Wang, Qinfen Huang, Liying Yu, Chunliu Pan
Summary: Through physiological response analysis, transcriptomics, and metabolomics, this study reveals the stress response mechanisms and metabolic changes in Gynostemma pentaphyllum under cadmium stress. It is found that G. pentaphyllum enhances antioxidant enzyme activity and accumulation of proline and polysaccharides under cadmium stress. Transcriptomics and metabolomics analysis identify genes and metabolic pathways associated with cadmium stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xuechun Zhang, Shi Li, Zhibin Zhang, Kin Weng Kong, Zhenxing Wang, Xiahong He
Summary: This study found that short-term fermentation with probiotics can enhance the content and bioactivity of active components in Gynostemma pentaphyllum leaves, while prolonged fermentation may lead to a decline in these aspects. Among the four probiotics studied, SWFU D16 fermentation for 2 days showed the best effect, significantly improving the total phenolic and total flavonoid content, antioxidant capacity, and inhibitory ability against α-glucosidase activity.
Article
Biochemistry & Molecular Biology
Yun-Yun Lou, Xian Zheng, Ya-Ping Huang, Long Mu, Xiao-Gai Zhang, Zhi-Wei Zhao, Zhe Song, Jian Zhang, Zhi-Qi Yin, Ke Pan
Summary: This study isolated and structurally characterized novel, minor gypenosides from Gynostemma pentaphyllum, and evaluated their Sirt1 agonist activity. Results showed satisfactory Sirt1 agonist activity in four saponins, indicating the potential for further research on G. pentaphyllum as a source of Sirt1 agonists.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Wei-Ye Cui, Yulian Jin, Hui Liu, Ma-Li Zu, Xin-Fang Zhai, Ce Yang, Yu-Long Gu, Yong Cheng, Xiang-Lan Piao
Summary: Two dammarane-type saponins were isolated from the heat-processed Gynostemma pentaphyllum, showing moderate activity against human lung carcinoma A549 cells. In vitro assays revealed that damulin E and damulin F exhibited moderate activity against various cell lines.
NATURAL PRODUCT RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Chao Su, Nan Li, Ruru Ren, Yingli Wang, Xiaojuan Su, Fangfang Lu, Rong Zong, Lingling Yang, Xueqin Ma
Summary: Gynostemma pentaphyllum, also known as Jiaogulan, is a tea traditionally consumed for its taste and weight loss benefits, but is now recognized for its various bioactive compounds with medicinal properties. Studies have shown that it possesses anti-cancer, anti-atherogenic, anti-dementia, and anti-Parkinson's disease effects, as well as lipid-regulating, neuroprotective, hepatoprotective, and hypoglycemic properties. Ongoing research on its chemical constituents and pharmacological activities has shown promising potential for treating various human diseases.
Article
Chemistry, Medicinal
Jun Wang, Xian-Hua Meng, Wei-Feng Wang, Chun-Yan Sang, Thi-Kim-Quy Ha, Jun-Li Yang
Summary: Three unreported dammarane-type triterpenoids with rare skeletons and one undescribed gypenoside were isolated from Gynostemma pentaphyllum. Their structures and configurations were determined, and their antiproliferative effects against cell lines were tested. Three compounds exhibited moderate cytotoxicity.
Review
Food Science & Technology
Aftab Ahmed, Muhammad Awais Saleem, Farhan Saeed, Muhammad Afzaal, Ali Imran, Muhammad Nadeem, Saadia Ambreen, Muhammad Imran, Muzzamal Hussain, Entessar Al Jbawi
Summary: Gynostemma pentaphyllum, also known as an immortal herb, belongs to the Cucurbitaceae family and is native to China. It has gained attention for its rich phytochemistry, particularly its saponins and sterols. This review provides a comprehensive overview of its taxonomic classification, botanical description, geographical distribution, and in-depth analysis of its therapeutic properties and pharmacological features.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2023)
Article
Genetics & Heredity
Ding Huang, Ruhong Ming, Shiqiang Xu, Jihua Wang, Shaochang Yao, Liangbo Li, Rongshao Huang, Yong Tan
Summary: This study reported a high-quality genome of Gynostemma pentaphyllum and revealed the biosynthetic pathway and potential regulatory network of gypenoside. Through tissue-specific gene co-expression network analysis, four UGTs genes were found to be involved in leaf-specific gypenoside biosynthesis.
Article
Pharmacology & Pharmacy
Jin-Bo Xie, Peng Xie, Mei Guo, Fang-Fang Li, Man-Yu Xiao, Yan-Shuang Qi, Wen-Jing Pei, Hao-Tian Luo, Yu-Long Gu, Xiang-Lan Piao
Summary: Gypenosides of heat-processed Gynostemma pentaphyllum (HGyp) show potential therapeutic effects on high-fat diet-induced glucose metabolic disorders (GMD) by reducing body weight, blood glucose, and improving blood lipid levels. HGyp also exhibits protective effects on liver and kidney health by reducing tissue damage. The AGE-RAGE signaling pathway may be involved in its therapeutic effects.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)