期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 625, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.122055
关键词
Mesalazine/Mesalamine/5-aminosalicylic acid; OPTICORE; Colonic delivery; Scintigraphy; Ulcerative colitis; Samarium
资金
- Tillotts Pharma AG
This study demonstrates that a dual pH and enzymatic triggered release system in combination with an inner alkaline layer can promote mesalazine release at the target site with high accuracy. The three differently coated tablets showed comparable release characteristics in biorelevant dissolution media.
Colonic targeting of orally applied therapeutic drugs remains a challenge. Tablet coatings relying on gastroin-testinal pH and colonic bacterial enzymes as triggers in association with an inner alkaline layer are expected to improve targeting efficiency. Mesalazine release from three differently coated tablets labelled with 1 MBq 153Sm was characterised in a single centre, open-label, parallel group study in nineteen healthy subjects and seven patients with mildly active ulcerative colitis. Two semi-organic and one aqueous-based outer coating with different ratios of enteric polymer and resistant starch were tested. All coatings showed comparable release lagtimes in biorelevant dissolution media and were not affected by neutron-activation of the samarium tracer. Mesalazine pharmacokinetics and gamma scintigraphy were used to characterise drug release, anatomical site of tablet disintegration and gastrointestinal transit. Initial tablet disintegration occurred at the ileo-caecal junction or beyond in 92 % of the subjects. Time to initial tablet disintegration was inversely correlated with maximal plasma concentrations and systemic mesalazine exposure. Although high inter-subject variability precluded detection of differences between solvent types and different enteric polymer to polysaccharide ratios, the dual pH and enzymatic triggered release system in combination with an inner alkaline layer promoted mesalazine release at the target site with high accuracy.
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