Article
Polymer Science
Shehla Mushtaq, Muhammad Asad Abbas, Habib Nasir, Azhar Mahmood, Mudassir Iqbal, Hussnain A. Janjua, Qamar Malik, Nasir M. Ahmad
Summary: The study focuses on mitigating the detrimental effects of algae biofouling on manufacturing processes by developing environmentally friendly active antialgal cationic amphiphilic copolymers. Increasing PDMAEMA concentration enhances the copolymers' antialgal performance, reducing algae adhesion. Copolymers with higher DMAEMA concentration exhibit stronger hydrophilicity and lower adhesion to Dictyosphaerium algae.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Nadiyah Alahmadi, Mahmoud A. Hussein
Summary: The study aims to fabricate hybrid nanocomposite membranes containing cellulose acetate reinforced by pure zinc oxide or mixed metal oxides for biological interest. The chemical structure, thermal stability, and biological activity of the fabricated materials were investigated.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Polymer Science
Elizaveta S. Permyakova, Anton M. Manakhov, Philipp V. Kiryukhantsev-Korneev, Denis V. Leybo, Anton S. Konopatsky, Yulia A. Makarets, Svetlana Yu. Filippovich, Sergey G. Ignatov, Dmitry V. Shtansky
Summary: In this study, ZnO-modified polycaprolactone nanofibers were developed and showed high antibacterial and antifungal activity against Gram-positive and Gram-negative pathogenic bacteria and pathogenic fungi.
Article
Polymer Science
Helena Oliver-Ortega, Shiyu Geng, Francesc Xavier Espinach, Kristiina Oksman, Fabiola Vilaseca
Summary: The study focused on utilizing bacterial cellulose from kombucha tea fermentation as a reinforcing nanofiber network in PMMA matrix, leading to the creation of lightweight, porous nanocomposites with excellent mechanical properties. The nanofibrils in the KBC network had diameters ranging between 20-40 nm and exhibited high crystallinity (>90%). The prepared nanocomposites showed uniform structure, high stiffness, and were homogeneously impregnated with the PMMA matrix, demonstrating the potential of KBC as a template for polymer nanocomposites.
Article
Engineering, Chemical
Charlene Kaye Solomon Haresco, Micah Belle Marie Yap Ang, Bonifacio T. Doma, Shu-Hsien Huang, Kueir-Rarn Lee
Summary: Novel P(DA-SBMA) nanoparticles were synthesized and embedded in thin-film nanocomposite membranes to enhance membrane separation efficiency and hydrophilicity. The optimal TFNP(DA-SBMA)-0.55 membrane exhibited high salt rejections and pure water flux, along with excellent anti-fouling properties against proteins.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Physical
Jonas Blahnik, Sebastian Krickl, Klaus Schmid, Eva Mueller, John Lupton, Werner Kunz
Summary: This article presents a free-radical polymerization method in a mesostructured system without surfactants or other auxiliary agents. The aim is to study the impact of surfactant-free mesostructuring on polymerization kinetics and derived polymers.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Tony Tiainen, Jere K. Mannisto, Heikki Tenhu, Sami Hietala
Summary: Poly(aminoethyl methacrylate) (PAEMA), poly-(ethylene oxide)-block-(aminoethyl methacrylate) (PEO-PAEMA), and their derivatives were studied for their capabilities for CO2 adsorption and release. PGEMA showed the most promising results with a CO2 adsorption capacity of 2.4 mmol/g at room temperature and a desorption temperature of 72 degrees C. Relations between the polymer chemical composition and CO2 adsorption and release characteristics were revealed, providing useful insights for future formulations of CO2 adsorbent polymer materials.
Article
Materials Science, Multidisciplinary
Parand Khadivar, Safoura Khajeniazi, Afzal Karimi
Summary: A biocompatible nanoscaffold was synthesized for wound regeneration, showing good physical, chemical, and biological properties. The scaffold was proven to assist in wound healing, with improved water uptake capacity and adhesive properties.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Engineering, Chemical
Sachin Karki, Moucham Borpatra Gohain, Diksha Yadav, Neha R. Thakare, Radheshyam R. Pawar, Swapnali Hazarika, Pravin G. Ingole
Summary: Novel TFN membranes were developed by incorporating amine-rich synthetic talc (NHST) nanosheets within diethylenetriamine (DETA) and trimesoyl chloride (TMC) monomers over a polydopamine (PDA) coating layer. The in-situ synthesized NHST nanosheet phases were confirmed by various characterization techniques, and the results showed improved permeability and rejection with a small amount of NHST doping in the TFN layer.
Review
Materials Science, Paper & Wood
Izabela Zaborniak, Pawel Chmielarz
Summary: This paper reviews the synthetic routes for functionalization of cellulose membranes by polymer chains with controlled structures. It evaluates prior research on ATRP techniques and compares low ppm ATRP methods with conventional approaches. The paper also highlights the advantages and prospects of using cellulose as a membrane-built substrate.
Article
Engineering, Environmental
Alireza Hosseinzadeh, Ali Bozorg, Parviz Rashidi Ranjbar
Summary: In this study, a novel nanocomposite was developed by functionalizing the synthesized magnetic-graphene oxide with crystalline nanocellulose and zwitterionic polymers to address the challenges of bio-fouling in ultrafiltration membranes. The nanofiller improved the hydrophilicity and roughness of the membranes, resulting in higher water flux, flux recovery ratio, and anti-fouling properties. The hydration layer formed by the zwitterionic groups on the nanocomposite surface reduced the adhesion of biomolecules and microorganisms, providing advanced anti-fouling properties. The nanocomposite membranes also exhibited improved biofouling resistance against Gram-positive/negative bacteria through anti-adhesion or antimicrobial mechanisms.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Materials Science, Paper & Wood
Muhammad Asif Iqbal, Toheed Akhter, Muhammad Faheem, Asif Mahmood, Waheed Al-Masry, Sohail Nadeem, Sadaf Ul Hassan, Chan Ho Park
Summary: We synthesized a thermoresponsive polymer with a narrow molecular weight distribution using organic photo-redox-catalyzed atom transfer radical polymerization (O-ATRP). The O-ATRP was mediated by a photoredox catalyst 1,2,3,5-tetrakis (carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) under visible light irradiation. The polymerization of polymethyl methacrylate (PMMA) chains from a hydroxypropyl cellulose (HPC)-based macroinitiator was characterized using various analytical methods. The resulting PMMA-grafted HPC (PMMA-g-HPC) showed a widened lower critical solution temperature (LCST) window and an inverse pH dependency of the LCST, making it promising for various applications including drug delivery systems.
Article
Polymer Science
Thi Phuong Thu Nguyen, Nadine Barroca-Aubry, Ludovic Costa, Yann Bourdreux, Gilles Doisneau, Philippe Roger
Summary: This study reports for the first time the controlled synthesis of PPFPMA through Cu(0)-mediated RDRP method, investigating influencing factors and finding the optimal conditions to successfully synthesize low dispersity PPFPMA with controlled polymerization features.
Article
Energy & Fuels
Mahtab Hamrahjoo, Saeed Hadad, Elham Dehghani, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: In this study, nanocomposite gel polymer electrolyte films based on poly(poly[ethylene glycol] methyl ether methacrylate)/graphene oxide were prepared using different polymerization methods. The films prepared via conventional free radical polymerization with 0.3 wt.% graphene oxide showed the highest ionic conductivity and excellent interface compatibility. These nanocomposite electrolyte films also exhibited good thermal stability and electrochemical performance.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2022)
Article
Materials Science, Paper & Wood
Sepideh Hamedi, Seyed Abbas Shojaosadati
Summary: Nanocomposite hydrogel plays a crucial role in wound healing, with the addition of ZnO nanoparticles and functionalization of bacterial cellulose enhancing its properties and antibacterial effects. It can also stimulate the proliferation of human fibroblast cells.
Article
Biochemistry & Molecular Biology
Ana C. Q. Silva, Barbara Pereira, Nicole S. Lameirinhas, Paulo C. Costa, Isabel F. Almeida, Patricia Dias-Pereira, Ines Correia-Sa, Helena Oliveira, Armando J. D. Silvestre, Carla Vilela, Carmen S. R. Freire
Summary: The aim of this study is to prepare dissolvable biopolymeric microneedle (MN) patches composed solely of sodium carboxymethylcellulose (CMC) for the transdermal delivery of diclofenac sodium salt (DCF). The MNs showed adequate morphology, thermal stability, and the required mechanical strength for skin insertion. Experiments demonstrated the insertion capability and dissolution of the patches, as well as their noncytotoxicity.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Applied
Rodrigo T. Neto, Sonia A. O. Santos, Joana Oliveira, Armando J. D. Silvestre
Summary: The molecular characteristics of proanthocyanidins, especially mean degree of polymerization (mDP), significantly influence their anti-inflammatory and antioxidant activities. Conventional extraction techniques cannot overcome the compositional variabilities in proanthocyanidin extracts. Eutectic solvents, a new class of solvents, can be customized for specific applications. By adjusting the eutectic solvent's composition, proanthocyanidins with specific mDP values can be obtained regardless of the raw material. The use of a quaternary eutectic solvent system successfully standardized proanthocyanidin extracts' mDP from grape pomace, overcoming the limitations of conventional solvents.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Environmental Sciences
Maria Bartolomeu, Carlos J. P. Monteiro, Milton Fontes, Maria Graca P. M. S. Neves, Maria Amparo F. Faustino, Adelaide Almeida
Summary: This study aimed to evaluate the applicability of photodynamic inactivation (PDI) in real wastewater contexts for microbial inactivation. The results showed that PDI is an effective and promising disinfection method with a bacterial reduction of >3.0 log CFU/mL within the first hour of treatment. However, the physicochemical composition of water matrices should be considered as it can affect PDI efficacy, especially the pH, with acidic conditions showing better PDI performance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nanoscience & Nanotechnology
Tiago Carvalho, Raquel Bartolo, Sonia N. Pedro, Bruno F. A. Valente, Ricardo J. B. Pinto, Carla Vilela, Mohammad-Ali Shahbazi, Helder A. Santos, Carmen S. R. Freire
Summary: Biopolymeric injectable hydrogels have been developed for myocardial regeneration applications, but they usually lack desired functionalities. In this study, gold nanoparticles (AuNPs) were synthesized using lysozyme nanofibrils (LNFs) as nanotemplates and incorporated into gelatin-hyaluronic acid (HA) hydrogels. The resulting nanocomposite hydrogels showed improved properties such as rheological properties, mechanical resilience, antioxidant activity, and electrical conductivity. The presence of AuNPs also allowed the hydrogels to be monitorable through computer tomography. This work demonstrates the excellent potential of LNFs and AuNPs@LNFs for formulating functional injectable biopolymeric nanocomposite hydrogels for myocardial regeneration applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Carlos J. P. Monteiro, Maria G. P. M. S. Neves, Cristina Nativi, Adelaide Almeida, Maria Amparo F. Faustino
Summary: Cellulose is a versatile starting material for developing sustainable materials, and its combination with photoactive dyes enables selective microorganism killing in antimicrobial photodynamic therapy. This review focuses on porphyrinic photosensitizers supported on cellulose materials and their synthetic routes for effective photoinactivation. The efficiency of cellulose-based photoactive dyes for cancer treatment using photodynamic therapy is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sofia N. N. Sarabando, Cristina J. J. Dias, Catia Vieira, Maria Bartolomeu, Maria G. P. M. S. Neves, Adelaide Almeida, Carlos J. P. Monteiro, Maria Amparo F. Faustino
Summary: Sulfonamides are effective antibiotics against infections but misuse leads to antibiotic resistance. Porphyrins and analogs have shown good photosensitizing properties as antimicrobial agents, including against MRSA. This study synthesized and evaluated a new sulfonamide-functionalized meso-arylporphyrin and its Zn(II) complex for antibacterial activity against MRSA, both with and without the co-adjuvant KI. Photodynamic studies demonstrated effective photoinactivation of MRSA by all the porphyrin derivatives, with significantly improved outcomes when combined with KI.
Article
Pharmacology & Pharmacy
Sonia N. Pedro, Ana T. P. C. Gomes, Carla Vilela, Carla Vitorino, Rosa Fernandes, Adelaide Almeida, Maria Helena Amaral, Mara G. Freire, Armando J. D. Silvestre, Carmen S. R. Freire
Summary: A new type of microemulsion based on deep eutectic solvent (DES) has been developed to improve the efficacy of antibiotics in ocular infections. By using betaine-based DES aqueous solutions, the water solubility of the antibiotic chloramphenicol can be increased up to 140-fold. These DES solutions are applied as water phases in stable water-in-oil-in-water (w/o/w) microemulsions, achieving sustained-release and higher permeation through the cornea. Compared to commercialized eye drops, these microemulsions show higher antimicrobial activity and faster action against methicillin-resistant Staphylococcus aureus (MRSA) infections.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Applied
Paloma Lopes, A. Sofia M. Joaquinito, Artur Ribeiro, Nuno M. M. Moura, Ana T. P. Gomes, Susana G. Guerreiro, M. Amparo F. Faustino, Adelaide Almeida, Paula Ferreira, Manuel A. Coimbra, M. Graca P. M. S. Neves, Idalina Goncalves
Summary: This study explores the feasibility of incorporating cationic TMPyP into starch-based films to enhance their physicochemical, mechanical, antimicrobial, and wound healing abilities. The results showed that TMPyP not only gave the films a reddish color but also increased their hydrophobicity and the mobility of starch polymeric chains. The films effectively photoinactivated Escherichia coli and facilitated the wound healing process. Thus, the incorporation of TMPyP into starch-based formulations is a promising strategy for developing water tolerant and photosensitive biomaterials that can act as multitarget antimicrobial medical dressings and carriers of active compounds for effective wound healing.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Tania Almeida, Anna Karamysheva, Bruno F. A. Valente, Jose M. Silva, Marcia Braz, Adelaide Almeida, Armando J. D. Silvestre, Carla Vilela, Carmen S. R. Freire
Summary: It is found that the use of bioactive transparent nanocomposite films can enhance the mechanical properties and water resistance of food packaging. These films also have UV-blocking and antioxidant activities, as well as antibacterial and weight loss delay capabilities.
FOOD HYDROCOLLOIDS
(2023)
Article
Polymer Science
Filipe S. Matos, Sara Fateixa, Niklas von Weymarn, Carmen S. R. Freire, Armando J. D. Silvestre, Carla Vilela
Summary: In this study, sustainable functional fibers with low environmental foot-print and superior properties were manufactured by functionalizing regenerated cellulose fibers with a natural derived phosphorus compound. The modified fibers exhibited phosphorus content up to 1.80% and a uniform and smooth surface morphology. They also showed moderate antioxidant activity, water contact angles below 92 degrees, and good thermal-oxidative stability. The flame-retardant performance of the fibers was excellent, with the fibers ceasing to burn before flaming or glowing, even after several flame applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Biomedical
Sonia N. Pedro, Bruno F. A. Valente, Carla Vilela, Helena Oliveira, Adelaide Almeida, Mara G. Freire, Armando J. D. Silvestre, Carmen S. R. Freire
Summary: A switchable pullulan-based film that can transform into an adhesive hydrogel upon water absorption has been developed for the delivery of photosensitizers. The film exhibits high extensibility and adhesiveness, making it suitable for the treatment of resistant skin infections.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Applied
Sara R. D. Gamelas, Maria Bartolomeu, Thierry J. Gomes, Maria A. F. Faustino, Joao P. C. Tome, Augusto C. Tome, Adelaide Almeida, Ana T. P. C. Gomes, Leandro M. O. Lourenco
Summary: Viruses, especially RNA viruses, have a high mutation rate which leads to their resistance to traditional antivirals. Photodynamic treatment is a potential method that does not promote the development of resistance. In this study, new cationic ZnPcs were synthesized and successfully used for the photodynamic inactivation of a RNA-virus model.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
