Article
Chemistry, Multidisciplinary
Johnson John, Navatha Shree Sharma, Guosheng Tang, Zeyu Luo, Yajuan Su, Shelbie Weihs, S. M. Shatil Shahriar, Guangshun Wang, Alec McCarthy, Justin Dyke, Yu Shrike Zhang, Ali Khademhosseini, Jingwei Xie
Summary: This study introduces a strategy to use nanofiber aerogels combined with the LL-37-mimic peptide W379 for accelerated healing of diabetic wounds, showing great potential for clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Ji-Hwan Ha, Jae Yun Kim, Dahong Kim, Junseong Ahn, Yongrok Jeong, Jiwoo Ko, Soonhyoung Hwang, Sohee Jeon, Young Jung, Jimin Gu, Hyeonseok Han, Jungrak Choi, Gihun Lee, Moonjeong Bok, Su A. Park, Yee Sook Cho, Jun-Ho Jeong, Inkyu Park
Summary: This study develops an electrospun composite micro/nanofiber-based bilayer-dressing patch with a healing-support layer and a protective/monitoring layer. The healing-support layer enhances cell regeneration and biocompatibility for rapid healing. The protective/monitoring layer exhibits excellent antimicrobial properties and visible color changes within the pH range of wound lesions, suitable for advanced wound care. Wounds on BALB/c mice heal rapidly in 12 days, and the wound state can be diagnosed by the color change of the dressing patch. This multifunctional wound dressing patch promotes wound healing and facilitates convenient wound management.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Dermatology
Mehrdad Moosazadeh Moghaddam, Behrouz Farhadie, Reza Mirnejad, Hamid Kooshki
Summary: In this study, an amniotic membrane-based skin scaffold was developed using silk fibroin as a carrier and CM11 antimicrobial peptide. The scaffold was characterized and analyzed for its mechanical properties, biodegradation, peptide release, and cell cytotoxicity. The antimicrobial activity of the scaffold was tested against antibiotic-resistant strains, and its in vivo biocompatibility was evaluated through animal experiments. The scaffold was found to have proper antimicrobial properties and promoted wound healing in a mouse model.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Yukang Liu, Chaofei Li, Zhangbin Feng, Biao Han, Deng-Guang Yu, Ke Wang
Summary: This article briefly reviews the pathogenesis and commonly used dressings of chronic diabetic wounds, and emphasizes on the advantages of electrospun nanofibers in the treatment of diabetic wounds. It also summarizes the reports of different types of nanofiber dressings on diabetic wounds. The article highlights the method of using multi-drug combination therapy in diabetic wounds, providing new ideas for the effective treatment of diabetic wounds.
Article
Engineering, Biomedical
Pragya Singh, Prashant Pandey, Dilip Kumar Arya, Md Meraj Anjum, Subramaniam Poonguzhali, Abhishek Kumar, Ravi Gupta, Vijayakumar Mahalingam Rajamanickam, Sanjay Singh, Sundeep Chaurasia, Ajay Kumar Dantuluri, Sean Mcmahon, Paruvathanahalli Siddalingam Rajinikanth
Summary: The developed electrospun nanofiber yarns loaded with vancomycin and ferulic acid show excellent antimicrobial activity and wound healing potential, making them suitable for surgical wound healing applications.
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Rajib Dey, Riya Mukherjee, Jayanta Haldar
Summary: This report introduces an intrinsically antimicrobial hydrogel (HyDex) that exhibits broad-spectrum antimicrobial activity, hemostatic ability, and rapid wound closure efficacy. The hydrogel demonstrates effective antibacterial and antifungal effects, rapid blood clotting, and reduction in inflammatory responses in various models, showing great potential in addressing resistant bacteria, fungal infections, bleeding, and inflammation.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Ziwei Jiang, Zijun Zheng, Shengxiang Yu, Yanbin Gao, Jun Ma, Lei Huang, Lei Yang
Summary: Nanofiber scaffolds have unique properties that make them a revolutionary drug delivery platform for wound healing, but there are challenges in achieving controlled drug loading and release. This comprehensive study reviews the applications and recent advances in drug-laden nanofiber scaffolds for skin-wound management. Methods for preparation and polymers used in nanofiber production are introduced, along with different drug delivery methods. The article also discusses the application of drug-loaded nanofiber scaffolds for wound healing and stimulus-responsive drug delivery schemes.
Review
Biochemistry & Molecular Biology
Mohammad Ebrahim Astaneh, Narges Fereydouni
Summary: Diabetic wounds pose a significant clinical challenge due to impaired healing and increased risk of complications. Nanofiber-based wound dressings, particularly those containing hyaluronic acid, show promise in promoting wound healing by enhancing skin hydration, controlling inflammation, and facilitating revascularization. However, challenges and limitations, such as reproducibility and proper characterization, exist in the field of nanofiber technology. Future directions involve addressing these issues and optimizing nanofiber formulations for improved efficacy in diabetic wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Hongyu Lv, Meng Zhao, Yiran Li, Kun Li, Shaojuan Chen, Wenwen Zhao, Shaohua Wu, Yantao Han
Summary: This study developed a novel nanofibrous dressing for the treatment of hard-to-heal diabetic wounds. The dressing exhibited multiple biological functions, including anti-inflammation, antioxidation, pro-angiogenesis, and hemostasis.
Review
Pharmacology & Pharmacy
Paolo Pino, Francesca Bosco, Chiara Mollea, Barbara Onida
Summary: Chronic wounds are a global health concern, with increasing incidence due to age and age-related comorbidities. Antimicrobial bionanocomposites, such as nano-ZnO-BNC, offer promising solutions for wound healing with their antimicrobial properties. However, standardized testing procedures and a comprehensive understanding of their antimicrobial mechanism are still lacking.
Article
Engineering, Multidisciplinary
Fan Yu, Atta Ur Rehman Khan, Yaqiang Li, Binan Zhao, Xianrui Xie, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Jun Li, Jianfeng Pan, Xiumei Mo
Summary: In this study, a multifunctional nanofiber reinforced photo-crosslinking hydrogel wound dressing based on natural biomaterials was developed. The wound dressing mimics the structure and components of the native extracellular matrix (ECM). It exhibited excellent antibacterial effect, antioxidant property, and printability through 3D printing. Furthermore, it promoted angiogenesis, re-epithelialization, and wound healing when applied to full-thickness skin defects.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Infectious Diseases
Ali Pormohammad, Nadia K. Monych, Sougata Ghosh, Diana L. Turner, Raymond J. Turner
Summary: Wounds continue to be a serious medical concern, with infectious microbes in biofilm form delaying the healing process. Developing novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm, and wound healing properties are necessary. Nanomaterials show promising applicability for various wound types with their unique properties.
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xiaofang Chen, Yaqin Chen, Bofei Fu, Kunjie Li, Donghong Huang, Chaohui Zheng, Minghuan Liu, Da-Peng Yang
Summary: In this study, CuS nanoparticles were prepared using eggshell membranes as templates and a multifunctional nanofibrous membrane was synthesized. The nanofiber membrane exhibited antibacterial, hemostatic, and wound healing properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Seyyed-Mojtaba Mousavi, Zohre Mousavi Nejad, Seyyed Alireza Hashemi, Marjan Salari, Ahmad Gholami, Seeram Ramakrishna, Wei-Hung Chiang, Chin Wei Lai
Summary: Electrospun dressings have shown promising advancements in wound healing applications by accelerating the healing process and enhancing therapeutic potential. Incorporating various bioactive agents can improve the effectiveness of electrospun dressings, with different commercial products available for selection.
Article
Polymer Science
Gopi Lavanya, Deivanayagam Paradesi, Pushparaj Hemalatha
JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY
(2020)
Article
Polymer Science
Murali Prathap, Kulasekaran Poonkuzhali, Maria Mahimai Berlina, Pushparaj Hemalatha, Deivanayagam Paradesi
HIGH PERFORMANCE POLYMERS
(2020)
Article
Pharmacology & Pharmacy
Kousalya Prabahar, Ubaidulla Udhumansha, Mona Qushawy
Article
Pharmacology & Pharmacy
Omprakash Gadgeppa Bhusnure, Sachin Bhagwat Gholve, Padmaja Sidram Giram, Abhimanu Vilas Gaikwad, Ubaidulla Udumansha, Ganesh Mani, Jang Hyun Tae
Summary: The study developed an effective nanofiber formulation using PVA and PVP polymers to embed and release the anticancer drug 5-FU for treating colon cancer. The drug-loaded nanofibers exhibited excellent drug loading efficiency, controlled release mechanism, and enhanced anticancer performance in vitro cell experiments.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kousalya Prabahar, Ubaidulla Udhumansha, Nehal Elsherbiny, Mona Qushawy
Summary: This study developed a transdermal drug delivery system using a nanostructured lipid carrier to deliver 13-sitosterol for the treatment of androgenic alopecia. The system demonstrated significant enhancement of hair growth in experimental rats and holds potential for effective treatment of androgenic alopecia.
Article
Engineering, Chemical
Brindhamani Ravi, Ganesh Mani, Hemalatha Pushparaj, Hyun Tae Jang, Vijayabaskaran Manickam
Summary: This study presents the successful application of Sida cordata extract in the renewable bio-inspired green synthesis of silver nanoparticles. Characterization techniques were used to analyze the synthesized nanoparticles, which showed potential antimicrobial, antioxidant, and photocatalytic activities.
PARTICULATE SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Chemical
Bhusnure Omprakash Gadgeppa, Bhokare Manjusha Raman, Ganesh Mani, Giram Padmaja Sidram, Sachin Sivajirao Pandit, Jayaprakash Jaybalan, Kamalakkannan Kaliappan, Hemalatha Pushparaj, Jang Hyun Tae
Summary: This study successfully synthesized silver nanoparticles (AgNPs) using Achyranthes japonica root extract, and characterized the phytogenic AgNPs using various physiochemical methods. The results showed that AJ-AgNPs were spherical with an average size of 25 nm, and functional groups such as alcohols, phenols, carboxylic acids, ketones, and amines were detected. The synthesized AJ-AgNPs exhibited excellent antimicrobial activity against both Gram (-) ve and Gram (+) ve bacteria, as well as anti-biofilm, DPPH scavenging, and tyrosinase inhibition activities in a dose-dependent manner.
PARTICULATE SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ubaidulla Uthumansha, Kousalya Prabahar, Dilli Bhai Gajapathy, Mohamed El-Sherbiny, Nehal Elsherbiny, Mona Qushawy
Summary: This study aimed to enhance the oral bioavailability and therapeutic efficacy of the antihypertensive drug telmisartan by preparing oil-entrapped floating alginate beads. The results showed that the prepared beads exhibited high entrapment efficiency, in vitro buoyancy, and prolonged drug release. In vivo evaluation confirmed the extended antihypertensive activity of the telmisartan-loaded beads in animal models. This innovative delivery method has the potential to improve drug solubility, oral bioavailability, and patient compliance.
Article
Chemistry, Medicinal
Kousalya Prabahar, Ubaidulla Uthumansha, Nehal Elsherbiny, Mona Qushawy
Summary: The use of synthetic medication for treating alopecia is limited due to the risk of systemic exposure and related side effects. Recent studies have shown that beta-sitosterol (beta-ST), a natural compound, has potential in promoting hair growth. In this study, cubosomes with dissolving microneedles (CUBs-MND) were developed as a potential advanced dermal delivery system for beta-ST. The results showed that CUBs-MND demonstrated higher skin permeation and hair growth efficacy compared to CUBs alone, suggesting their superiority in the treatment of alopecia.
Proceedings Paper
Materials Science, Multidisciplinary
Jayabalan Jayaprakash, D. Sankari, Pernabas Johnthomas, Devadoss Johnmilton, Chandrasekaran Swaminathan, M. Sathish, Mani Ganesh
Summary: This study reports an eco-friendly, cost effective and biological synthesis of meropenem antibiotic conjugated silver nanoparticles. The nanoparticles exhibit increased antibacterial activity against various bacteria and also show good photocatalytic activity.
MATERIALS TODAY-PROCEEDINGS
(2022)
Review
Pharmacology & Pharmacy
V Sandhiya, U. Ubaidulla
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Biotechnology & Applied Microbiology
Jayaprakash Jayabalan, Ganesh Mani, Nandhini Krishnan, Johnthomas Pernabas, John Milton Devadoss, Hyun Tae Jang
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Rajangam Vinodh, Cadiam Mohan Babu, Aziz Abidov, Muthiahpillai Palanichamy, Wang Seog Cha, Hyun Tae Jang
Article
Biotechnology & Applied Microbiology
Mani Ganesh, Sung Gil Lee, Jayabalan Jayaprakash, Murugan Mohankumar, Hyun Tae Jang
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2019)
