Article
Immunology
Benquan Liu, Jun Jiang, Hua Liang, Ping Xiao, Xiaohong Lai, Jiayi Nie, Wenqiang Yu, Ying Gao, Shihong Wen
Summary: This study revealed the important role of natural killer T (NKT) cells in regulating renal fibrosis. Activation of NKT cells leads to more severe fibrosis, while CD1d deficiency protects mice from renal fibrosis. Targeting NKT cell/IL-4 signaling may be an effective treatment for renal fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Weiming Zhao, Lan Wang, Juntang Yang, Xinyu Chen, Xiaoshu Guo, Kai Xu, Ningdan Wang, Wenyu Zhao, Cong Xia, Hui Lian, Ivan Rosas, Guoying Yu
Summary: MMP19 promotes endothelial-to-mesenchymal transition and endothelial permeability, exacerbating pulmonary fibrosis. MMP19 interacts with ET1 and SDF1 to regulate the development of pulmonary fibrosis. Therefore, MMP19 could be a potential therapeutic target for suppressing pulmonary fibrosis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Environmental Sciences
Qiuyan Zhao, Changfu Hao, Jingjing Wei, Ruoxuan Huang, Chao Li, Wu Yao
Summary: BMSCs were found to significantly reduce lung inflammation, collagen deposition, and the production of fibronectin, primarily through the inhibition of apoptosis and pyroptosis rather than autophagy. This provides a new insight into the treatment of lung fibrosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Hongping Gu, Jinrong Li, Yuehan Ni
Summary: This study investigates the therapeutic effect of sinomenine on renal fibrosis and its mechanism. The results show that sinomenine can improve the progression of renal fibrosis by regulating the expression of miR-204-5p in exosomes from bone marrow mesenchymal stem cells and the PI3K-AKT pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Caijiao Yi, Jian Liu, Wen Deng, Chang Luo, Jinyan Qi, Mei Chen, Heping Xu
Summary: This study investigated the effect of ageing on subretinal fibrosis secondary to choroidal neovascularization and the mechanism of action. The results showed that ageing increased the number of circulating fibrocytes and the profibrotic potential of BM-derived macrophages. Additionally, aged mice had significantly more severe subretinal fibrosis compared to young mice. The transplantation of BM from aged mice significantly increased subretinal fibrosis in young mice.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Cell & Tissue Engineering
Yangge Du, Yunsong Liu, Yongsheng Zhou, Ping Zhang
Summary: In this study, the researchers found that knockdown of CDC20 promoted adipogenic differentiation of bone marrow mesenchymal stromal/stem cells (BMSCs), indicating a potential link between adipogenesis and bone loss disorders such as osteoporosis. The results suggest that CDC20 may be a therapeutic target for fatty bone and osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Engineering, Biomedical
Zhiwen Luo, Yaying Sun, Beijie Qi, Jinrong Lin, Yisheng Chen, Yuzhen Xu, Jiwu Chen
Summary: The study found that bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) can significantly inhibit the fibrogenic process in shoulder capsule fibrosis. BMSC-EVs suppressed abnormal proliferation and high collagen production in fibroblasts, improving shoulder mobility. The let-7a-5p molecule in BMSC-EVs was found to have anti-fibrotic effects by targeting TGFBR1 gene.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jiwei Hou, Jie Ji, Xiang Chen, Honghui Cao, Yi Tan, Yu Cui, Zou Xiang, Xiaodong Han
Summary: The study revealed the interaction between macrophages and fibrosis-associated alveolar epithelial cells, unveiling the mechanism of macrophage polarization and pulmonary fibrosis development, and suggesting Shh as a potential target for treating pulmonary fibrosis.
Article
Chemistry, Multidisciplinary
Tiemei Li, Xiaotao Su, Pinglan Lu, Xinmei Kang, Mengyan Hu, Chunyi Li, Shisi Wang, Danli Lu, Shishi Shen, Huipeng Huang, Yuxin Liu, Xiaohui Deng, Wei Cai, Lei Wei, Zhengqi Lu
Summary: Pneumonia is a common cause of death in patients with acute ischemic stroke (AIS), and antibiotics are not effective in improving the prognosis due to the negative impact on the immune system. However, a recent study found that bone marrow mesenchymal stem cells (BM-MSC) can reduce bacterial load in the lungs of stroke mice, and this is achieved by modulating the activities of pulmonary macrophages. The study also identified that BM-MSC releases migrasomes, which contain the antibacterial peptide dermcidin (DCD) and enhance the phagocytosis of macrophages.
Article
Cell & Tissue Engineering
Jiahui Jin, Qingjian Ou, Zhe Wang, Haibin Tian, Jing-Ying Xu, Furong Gao, Shuqin Hu, Jie Chen, Juan Wang, Jieping Zhang, Lixia Lu, Caixia Jin, Guo-Tong Xu, Jingjun Zhao
Summary: BMSC-derived EVs, carrying miRNAs, have shown similar efficacy to BMSCs in treating skin dysfunction in SSc, by regulating the WNT and TGF beta signaling pathways.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Orthopedics
Hairong Su, Yulan Yang, Wanchun Lv, Xiaoli Li, Binxiu Zhao
Summary: This study revealed that miR-382-secreted by hBMSCs plays an important role in osteogenic differentiation by targeting SLIT2 in MG63 cells. The miR-382-contained hBMSC-secreted sEV also showed potential therapeutic effects in regulating osteogenesis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Sarah Bouali, Roxann Hetu-Arbour, Celia Gardet, Krista M. Heinonen
Summary: Vangl2 is a crucial regulator in the self-renewal and differentiation of HSCs. Deletion of Vangl2 impairs HSC expansion and hematopoietic recovery, indicating its essential role in hematopoiesis regulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Guanghui Zhu, Yu Xia, Ziyue Zhao, Aoyu Li, Hui Li, Tao Xiao
Summary: This study found that BMSCs-derived exosomes can regulate the growth and metastasis of osteosarcoma through XIST. The mechanism involves the binding and down-regulation of miR-655 by XIST, leading to an increase in ACLY levels and activation of beta-catenin signal, thus promoting lipid deposition and the progression of osteosarcoma.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Roxann Hetu-Arbour, Mouna Tlili, Fabio Luiz Bandeira Ferreira, Belma Melda Abidin, Edward O. Kwarteng, Krista M. Heinonen
Summary: This study reveals a new autocrine role of Wnt4 in hematopoietic stem cell self-renewal, indicating that the regulation of Wnt signaling in hematopoiesis may not require Wnt secretion and could be independent of morphogen gradients.
Review
Respiratory System
Kakuhiro Yamaguchi, Hiroshi Iwamoto, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: RAGE receptor plays a homeostatic role in the lung, but its abnormal binding may lead to lung injury and the occurrence of ILD, including IPF. IPF patients have a poor prognosis, with AE-IPF being one of the main causes of death. ILD is frequently observed in patients with lung cancer, and procedures or chemotherapy may trigger AE-ILD, leading to increased mortality.
RESPIRATORY INVESTIGATION
(2022)
Article
Allergy
T. Otani, H. Iwamoto, Y. Horimasu, K. Yamaguchi, S. Sakamoto, T. Masuda, S. Miyamoto, T. Nakashima, K. Fujitaka, H. Hamada, N. Hattori
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Respiratory System
Naokazu Watari, Kakuhiro Yamaguchi, Hiroaki Terada, Kosuke Hamai, Ken Masuda, Yoshifumi Nishimura, Shinjiro Sakamoto, Takeshi Masuda, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Hiroyasu Shoda, Nobuhisa Ishikawa, Kazunori Fujitaka, Kozue Miyazaki, Yoshihiro Miyata, Hironobu Hamada, Kazuo Awai, Noboru Hattori
Summary: CT findings of METex14 skipping-positive NSCLC show that most tumors are large masses located in the upper lobes, often invading surrounding tissue and having internal low-density areas.
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, General & Internal
Noriaki Ito, Takeshi Masuda, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Taku Nakashima, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Kazuaki Chayama, Noboru Hattori
Summary: This case report describes a rheumatoid arthritis patient treated with MTX, who developed varicella pneumonia and meningoencephalitis due to VZV reinfection and EBV reactivation.
Article
Respiratory System
Hiroki Tanahashi, Kakuhiro Yamaguchi, Koji Kurose, Satoshi Nakao, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Toru Oga, Mikio Oka, Noboru Hattori
Summary: This study explored the potential of HMGB1 as a blood marker to predict the development and severity of checkpoint inhibitor pneumonitis (CIP) caused by anti-PD-1/PD-L1 therapy in non-small cell lung cancer (NSCLC) patients.
Article
Infectious Diseases
Keitaro Omori, Hiroki Kitagawa, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Kayoko Tadera, Toshihito Nomura, Norifumi Shigemoto, Gaku Aoki, Noboru Hattori, Hiroki Ohge
Summary: The prevalence of nontuberculous mycobacteria (NTM) infections is increasing worldwide. However, there is limited research on the clinical characteristics of extrapulmonary NTM. In this study, researchers analyzed the species distribution, infected sites, and risk factors of extrapulmonary NTM compared to pulmonary NTM. The results showed that younger age, corticosteroid use, and AIDS were associated with extrapulmonary NTM, and rapid-growing mycobacteria (RGM) were more prevalent in extrapulmonary NTM. The findings provide a better understanding of extrapulmonary NTM.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Chemistry, Medicinal
Jiantao Hu, Biao Hu, Fuming Xu, Mi Wang, Chong Qin, Donna McEachern, Jeanne Stuckey, Shaomeng Wang
Summary: By utilizing precise conformational control, we have developed two potent and highly selective BRD4 degraders, BD-7148 and BD-9136, which can rapidly degrade BRD4 protein in cells at concentrations as low as 1 nM and exhibit >= 1000-fold degradation selectivity over BRD2 or BRD3 protein. Proteomic analysis of >5700 proteins confirmed the high selectivity of these compounds for BRD4 degradation. A single dose of BD-9136 selectively and effectively depletes BRD4 protein in tumor tissues for >48 h. BD-9136 effectively inhibits tumor growth without adverse effects on mice and is more efficacious than the corresponding pan BET inhibitor. This study suggests that selective degradation of BRD4 is a potential strategy for the treatment of human cancers and demonstrates a strategy for the design of highly selective PROTAC degraders.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Taku Nakashima, Keitaro Omori, Masashi Namba, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: This study investigates the potential of soluble B7H3 (sB7H3) as a biomarker to predict prognosis in patients with fibrosing interstitial lung diseases (ILDs). The results show that BALF sB7H3 levels at the time of ILD diagnosis have independent prognostic potential on 5-year survival in patients with fibrosing ILDs.
RESPIRATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Shinichiro Miura, Hiroshi Iwamoto, Keitaro Omori, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Kazunori Fujitaka, Hironobu Hamada, Akihito Yokoyama, Noboru Hattori
Summary: This study aimed to clarify the clinical features of restrictive and non-restrictive preserved ratio impaired spirometry (PRISm). The results suggest that non-restrictive PRISm may be a precursor of chronic obstructive pulmonary disease and requires increased monitoring.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Kentaro Tokumo, Takeshi Masuda, Taku Nakashima, Masashi Namba, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Yoshihiro Miyata, Morihito Okada, Hironobu Hamada, Noboru Hattori
Summary: This study shows that PAI-1 is involved in tolerance to osimertinib through epithelial-mesenchymal transition in drug-tolerant non-small-cell lung cancer cells. Additionally, PAI-1 inhibitors can suppress the proliferation and expression of mesenchymal genes in tolerant cells. Based on these observations, PAI-1 may be a potential therapeutic target for overcoming osimertinib tolerance.
Article
Oncology
Biao Hu, Jiantao Hu
Summary: The study compared the differences between PROTAC ER degrader and SERD. It was found that PROTAC ER degrader ERD-148 can degrade ER alpha, including phosphorylated ER alpha, while SERD fulvestrant has reduced degradation potency on phosphorylated ER alpha. Furthermore, ERD-148 was able to degrade ER alpha in fulvestrant-resistant cells.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Genetics & Heredity
Biao Hu, Tianju Liu, Zhe Wu, Sem H. Phan, Karen Blyth
Summary: P53 can suppress the transcription and translation of C/EBP beta gene, and regulate the translation of LAP and LIP isoforms of C/EBP beta through the expression of eIF4E and eIF4E-BP1; furthermore, the 5'UTR region plays an important role in the differential control of LAP and LIP translation of C/EBP beta.
Article
Chemistry, Medicinal
Zhixiang Chen, Biao Hu, Rohan Kalyan Rej, Dimin Wu, Ranjan Kumar Acharyya, Mingliang Wang, Tianfeng Xu, Jianfeng Lu, Hoda Metwally, Yu Wang, Donna Mceachern, Longchuan Bai, Christina L. Gersch, Meilin Wang, Wenjing Zhang, Qiuxia Li, Bo Wen, Duxin Sun, James M. Rae, Shaomeng Wang
Summary: This study reports the discovery of a new class of potent ERα degraders with high oral bioavailability. The most promising compound, ERD-3111, exhibits potent degradation activity against ERα and effectively reduces the levels of wild-type and mutated ERα proteins in tumor tissues. ERD-3111 achieves tumor regression or complete tumor growth inhibition in different mouse models, making it a promising ERα degrader for the treatment of ER+ breast cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Takahiro Yamada, Taku Nakashima, Takeshi Masuda, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Nobuhiko Kamada, Noboru Hattori
Summary: Increasing evidence suggests a link between intestinal microbiota, including fungi, and diseases in distal organs. This study aimed to investigate the impact of changes in intestinal fungal microbiota on the development of pulmonary fibrosis. Mice with Candida albicans overgrowth in the intestine, induced by oral administration of antibiotics and C. albicans, exhibited accelerated bleomycin-induced pulmonary fibrosis. These mice also showed enhanced Th17-type immune response, which was alleviated by IL-17A-neutralizing antibody treatment. The study highlights the involvement of IL-17A-mediated endothelial-mesenchymal transition in Candida albicans-exacerbated pulmonary fibrosis.
JOURNAL OF PATHOLOGY
(2023)
Article
Medicine, General & Internal
Takashi Oda, Hiroshi Iwamoto, Sachio Takeno, Tomohiro Kawasumi, Kota Takemoto, Manabu Nishida, Nobuyuki Chikuie, Yuichiro Horibe, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Naoko Higaki, Takayuki Taruya, Yasushi Horimasu, Takeshi Masuda, Takao Hamamoto, Taku Nakashima, Takashi Ishino, Tsutomu Ueda, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Summary: This study aimed to investigate the etiology of olfactory dysfunction in patients with asthma and the relationship between fractional exhaled nitric oxide (FeNO) levels. The results showed that chronic rhinosinusitis was the most common etiology of olfactory dysfunction in asthma patients, with eosinophilic chronic rhinosinusitis being associated with high FeNO levels and non-eosinophilic chronic rhinosinusitis being associated with low FeNO levels. Additionally, this study supported the link between upper and lower airway inflammation in asthma patients with olfactory dysfunction.
MEDICINA-LITHUANIA
(2023)