Article
Cell Biology
Bojana Jakic, William J. Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter
Summary: The loss of nuclear orphan receptor NR2F6 enhances antigen-specific CD8(+) memory formation and boosts inflammatory cytokine responses in mice after bacterial infection. The enhanced memory formation is intrinsic to CD8(+) T cells and is established early in the antibacterial immune response, mediated by IFN-gamma. Blocking IFN-gamma normalizes the memory precursor cell formation, indicating potential therapeutic benefits of NR2F6 manipulation for memory CD8(+) T cell functionality.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen
Summary: T-AIM cells are a subset of memory T cells that develop memory features independently of antigen exposure. They exhibit characteristics similar to conventional memory cells, including antigen-specific responses and responsiveness to innate stimuli. T-AIM cells are suggested to provide additional levels of protection against infections and cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Miguel A. B. Mercado, Wuying Du, Priyangi A. Malaviarachchi, Jessica Gann, Lin-Xi Li
Summary: The study revealed that innate IFN-gamma is crucial for preventing systemic dissemination of Chlamydia, while IFN-gamma produced by CD4 T cells is largely redundant at the FRT mucosa.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Lang Jiang, Lu Liu, Miaomiao Zhang, Linxia Zhang, Cuisong Zhu, Qian He, Lilin Ye, Chen Zhao, Zejun Li, Jianqing Xu, Xiaoyan Zhang
Summary: Research has shown that CD8+ lung tissue resident memory T (T-RM) cells play a crucial role in protecting against respiratory viruses. By studying mouse infection models, it was found that lung CD8+ T-RM cells can quickly respond to antigen re-exposure and induce interferon-stimulated genes (ISGs) in the surrounding tissues. The study also revealed that the induction of certain important antiviral ISGs and the suppression of key inflammatory cytokines are dependent on IFN-gamma signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Snehanshu Chowdhury, Anwesha Kar, Debaleena Bhowmik, Anupam Gautam, Debashree Basak, Ishita Sarkar, Puspendu Ghosh, Deborpita Sarkar, Alvina Deka, Paramita Chakraborty, Asima Mukhopadhyay, Shikhar Mehrotra, Soumen Basak, Sandip Paul, Shilpak Chatterjee
Summary: IL-12 stimulation increases intracellular acetyl CoA levels in CD8(+) T cells, allowing them to maintain effector function in nutrient-deprived tumor microenvironments. Inhibition of ATP-citrate lyase, an enzyme involved in the glucose-citrate-acetyl CoA pathway, impairs IFN gamma production and viability of CD8(+) T cells in nutrient-restricted conditions. CD8(+) T cells cultured in high pyruvate-containing media acquire metabolic features of IL-12-stimulated CD8(+) T cells and display improved antitumor potential.
Article
Immunology
Ruoyu Chao, Mikako Nishida, Nahoko Yamashita, Miho Tokumasu, Weiyang Zhao, Ikuru Kudo, Heiichiro Udono
Summary: Metformin enhances IFNγ production by CD8(+) T cells through differential metabolic pathways and nutrient conditions, suggesting its potential application in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Weidong Shen, Xiangdong Wang, Huihui Xiang, Shunsuke Shichi, Hiroki Nakamoto, Saori Kimura, Ko Sugiyama, Akinobu Taketomi, Hidemitsu Kitamura
Summary: This study revealed that IFN-gamma-STAT1-mediated NK2R expression is involved in the induction of antitumor effector CD8(+) T cells in the tumor microenvironment, which contributes to suppressing the tumorigenesis of liver cancer cells in vivo.
Article
Immunology
Zhiqiang Zhu, Yuanyuan Qin, Qi Liang, Wei Xia, Tong Zhang, Wen Wang, Mengmeng Zhang, Taiyi Jiang, Hao Wu, Ye Tian
Summary: The coinfection rate of HBV in HIV patients increases as HIV disease progresses, possibly due to the reduced numbers of HBV-specific IFN-gamma-producing CD8+ T cells. Close monitoring of HBV serum markers from the early stage of HIV infection is necessary.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Taylor Schmit, Kai Guo, Jitendra Kumar Tripathi, Zhihan Wang, Brett McGregor, Mitch Klomp, Ganesh Ambigapathy, Ramkumar Mathur, Junguk Hur, Michael Pichichero, Jay Kolls, M. Nadeem Khan
Summary: This study identifies IFN-gamma-regulated CCR2(+) monocytes as the main driver of lung damage during IAV infection. IFN-gamma regulates the recruitment and inflammatory phenotype of CCR2(+) monocytes. CD8+ T cells are the main source of IFN-gamma in the infected lungs.
Article
Multidisciplinary Sciences
Lion F. K. Uhl, Han Cai, Sophia L. Oram, Jagdish N. Mahale, Andrew J. Maclean, Julie M. Mazet, Theo Piccirilli, Alexander J. He, Doreen Lau, Tim Elliott, Audrey Gerard
Summary: This study found that interferon-gamma (IFN-γ) coordinates the affinity and differentiation of CD8(+) T cells during infection. IFN-γ promotes the expansion of low-affinity T cells, allowing them to compete with high-affinity T cells, while also enhancing the entry of high-affinity T cells into the memory cell pool. IFN-γ is mainly provided by virtual memory T cells, a subset of T cells with memory features but without antigen experience.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Xiaoying Zhang, Mir Ali, Morgan Alexandra Pantuck, Xiaofeng Yang, Chih-Ru Lin, Karim Bahmed, Beata Kosmider, Ying Tian
Summary: This study reveals the importance of CD8 T-cell response and cytokine IFN-gamma in promoting AT2 cell activity during alveolar epithelial repair and regeneration after acute lung injury caused by bacterial pneumonia.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Zhen Zeng, Margaret Veitch, Gabrielle A. Kelly, Zewen K. Tuong, Jazmina G. Cruz, Ian H. Frazer, James W. Wells
Summary: The study revealed the critical role of CD8(+) T cells in SCC regression and showed that neutralization of Interferon-gamma inhibits CD8(+) T cell infiltration into SCC, thus preventing its regression.
Article
Immunology
Neha Sangewar, Suryakant D. Waghela, Jianxiu Yao, Huldah Sang, Jocelyn Bray, Waithaka Mwangi
Summary: This study identified highly cross-reactive BVDV-specific CD8(+) T cells in cattle and novel IFN-gamma-inducing CD8(+) T cell epitopes from different regions of BVDV polyprotein. These conserved epitopes were found to elicit broadly reactive CD8(+) T cell responses against diverse BVDV strains, suggesting their potential use in developing a more effective CD8(+) T cell-based BVDV vaccine.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Shanzhi Huang, Anchun Cheng, Mingshu Wang, Zhongqiong Yin, Juan Huang, Renyong Jia
Summary: This review summarizes the regulatory role of the ubiquitination system in TLR/RLR-mediated innate immunity and how viruses utilize this system to escape immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Qi Li, Simeng Wei, Yue Li, Fengjiao Wu, Xiaoling Qin, Zhongsha Li, Jingyu Li, Chang Chen
Summary: Blocking of PD-L1 promotes CD8+IFN-gamma+ T cell-mediated immune responses, exacerbating inflammation and increasing the burden of atherosclerosis under high-cholesterol diet. However, further studies are needed to explore whether PD-L1 activation could be a novel immunotherapy strategy for atherosclerosis.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Fiamma Salerno, Julian J. Freen-van Heeren, Aurelie Guislain, Benoit P. Nicolet, Monika C. Wolkers
JOURNAL OF IMMUNOLOGY
(2019)
Article
Oncology
Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young, Monika C. Wolkers
Article
Biochemistry & Molecular Biology
Rene Rauschmeier, Charlotte Gustafsson, Annika Reinhardt, Noelia A-Gonzalez, Luigi Tortola, Dilay Cansever, Sethuraman Subramanian, Reshma Taneja, Moritz J. Rossner, Michael H. Sieweke, Melanie Greter, Robert Mansson, Meinrad Busslinger, Taras Kreslavsky
Article
Immunology
Julian J. Freen-van Heeren, Branka Popovic, Aurelie Guislain, Monika C. Wolkers
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Ming Wang, Yalong Yang, Dilay Cansever, Yiming Wang, Crystal Kantores, Sebastien Messiaen, Delphine Moison, Gabriel Livera, Svetoslav Chakarov, Tobias Weinberger, Christopher Stremmel, Monika Fijak, Britta Klein, Christiane Pleuger, Zhexiong Lian, Wentao Ma, Qingzhi Liu, Kathrin Klee, Kristian Handler, Thomas Ulas, Andreas Schlitzer, Joachim L. Schultze, Burkhard Becher, Melanie Greter, Zhaoyuan Liu, Florent Ginhoux, Slava Epelman, Christian Schulz, Andreas Meinhardt, Sudhanshu Bhushan
Summary: Macrophages in the testis and epididymis originate from different stages of cell development and can self-maintain independently of bone marrow hematopoietic cells in a steady state. However, during radiation-induced macrophage ablation or infection, bone marrow-derived cells are recruited to the testis and epididymis, leading to an inflammatory response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Matthieu Rousseau, Conan Jo O'Brien, Eduardo Antequera, Hana Zdimerova, Dilay Cansever, Tracy Canton, Anna Zychlinsky Scharff, Molly A. Ingersoll
Article
Biochemistry & Molecular Biology
Melania Balzarolo, Sander Engels, Anja J. de Jong, Katka Franke, Timo K. van den Berg, Muhammet F. Gulen, Andrea Ablasser, Edith M. Janssen, Bas van Steensel, Monika C. Wolkers
Summary: The methylation of m6A in DNA enhances immunogenicity in murine immune cells, with the response being sequence-specific. This feature of epigenetic alterations in DNA could potentially be utilized for designing immune-modulating therapeutics.
Article
Immunology
Iva Lelios, Sebastian A. Stifter, Virginia Cecconi, Ekaterina Petrova, Mirjam Lutz, Dilay Cansever, Sebastian G. Utz, Burkhard Becher, Maries van den Broek, Melanie Greter
Summary: The research found that monocytes play a critical role in promoting UV-induced cutaneous squamous cell carcinoma, while Langerhans cells and dermal macrophages have negligible contribution to tumor formation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Anouk P. Jurgens, Branka Popovic, Monika C. Wolkers
Summary: T cells play a central role in the adaptive immune system, protecting us from infections. Activation prompts T cells to change gene expression and produce effector molecules rapidly to combat threats. Dormant T cells regulate protein production to survive and prepare for potential re-infections.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Benoit P. Nicolet, Nordin D. Zandhuis, V. Maria Lattanzio, Monika C. Wolkers
Summary: T cell homeostasis, differentiation, and effector function are intricately regulated by the fine-tuning of gene expression, including post-transcriptional mechanisms. Factors such as sequence conservation, GC content, and chemical modifications play a critical role in defining mRNA and protein levels in T cells. Alternative splicing can impact mRNA expression, protein production, and subcellular localization, while sequences and structures serve as binding hubs for miRNAs and RNA-binding proteins in T cells. Overall, post-transcriptional mechanisms play a crucial role in determining cellular fate decisions in T cells.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Cell Biology
Martina Spiljar, Karin Steinbach, Dorothee Rigo, Nicolas Suarez-Zamorano, Ingrid Wagner, Noushin Hadadi, Ilena Vincenti, Nicolas Page, Bogna Klimek, Mary-Aude Rochat, Mario Kreutzfeldt, Claire Chevalier, Ozren Stojanovic, Olivia Bejuy, Didier Colin, Matthias Mack, Dilay Cansever, Melanie Greter, Doron Merkler, Mirko Trajkovski
Summary: Research shows that cold exposure significantly ameliorates active experimental autoimmune encephalomyelitis (EAE) by decreasing MHCII on monocytes and suppressing T cell priming and pathogenicity through the modulation of monocytes. This suggests a beneficial energetic trade-off between cold-induced metabolic adaptations and autoimmunity in immune-mediated diseases.
Article
Immunology
Benoit P. Nicolet, Aurelie Guislain, Monika C. Wolkers
Summary: This study demonstrates that CD29 can be used to enrich for cytotoxic human CD4(+) T cells, which display a cytotoxic gene expression profile similar to CD8(+) T cells and produce proinflammatory cytokines and cytotoxic molecules. The expression of CD29 on CD4(+) T cells can also lead to target cell killing in vitro when transduced with a MART1-specific TCR.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Georg Petkau, Twm J. Mitchell, Krishnendu Chakraborty, Sarah E. Bell, Vanessa D. Angeli, Louise Matheson, David J. Turner, Alexander Saveliev, Ozge Gizlenci, Fiamma Salerno, Peter D. Katsikis, Martin Turner
Summary: RNA binding proteins ZFP36 and ZFP36L1 limit the rate of differentiation and the potency of activated CD8(+) T cells by directly binding mRNA of transcription factors and cytokines, enforcing dependency on costimulation for full T cell activation and effector differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Benoit P. Nicolet, Monika C. Wolkers
Summary: T cells play a crucial role in our defense against infections and malignancies. A study found that mRNA expression is a poor indicator of protein output in T cells, regardless of differentiation or activation status. However, a correlation was found between gene class-specific mRNA expression and protein expression, suggesting the role of gene characteristics in determining gene expression in T cells. The presence of AU-rich elements in the 3'UTR was also associated with mRNA and protein abundance in a T cell activation-dependent, gene class-specific manner.
Meeting Abstract
Immunology
Nordin D. Zandhuis, Benoit P. Nicolet, Monika C. Wolkers
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)