Article
Food Science & Technology
Zhen Zeng, Jinqiu Wang, Xuefei Wen, Yi Wang, Xiang Li, Dayu Liu, Fang Geng
Summary: In this study, the effects of three drying techniques on the morphology and texture of edible fruiting bodies of D. indusiata (EFD) were systematically assessed. Metabolomic analysis revealed significant changes in the abundance of metabolites in EFD samples dried using different techniques. Freeze drying preserved the microstructure of EFD samples and improved their appearance, texture, and rehydration properties. Vacuum drying and hot air drying influenced the abundance of taste-related compounds and enhanced the umami of EFD. The browning of hot air dried EFD was caused by Maillard reactions, oxidative degradation of ascorbic acid, and phenylalanine metabolic pathway.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Yong Lai, Qi Fang, Xiurong Guo, Hui Lei, Quan Zhou, Nannan Wu, Can Song
Summary: The gut microbiota, an important organ, plays a vital role in the health of the host. Prebiotics, such as polysaccharides from mushrooms like Dictyophora indusiata, can regulate the gut microbiota and promote the production of short-chain fatty acids, thus improving gut health.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2023)
Article
Polymer Science
Yu Kang, Zhi Liu, Yingyun Long, Baolong Wang, Xu Yang, Di Sha, Kai Shi, Xiangling Ji, Bai Li, Yonggang Liu
Summary: A two-step method was used to synthesize N,N,N-trimethyl chitosan (TMC) from chitosan, with molecular weight ranging from 29 to 136 kg/mol and quaternization degree from 70% to 82%. Size exclusion chromatography (SEC) coupled with multiangle laser light scattering was employed to analyze the molecular weight and chain conformation, showing a significant increase in chain flexibility upon N-methylation, possibly due to the breakage of intramolecular hydrogen bonds between chitosan repeating units.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Abdollah Hematian Sourki, Mohammad Ali Hesarinejad
Summary: In this research, the properties of a dilute barley beta-glucan (BBG) solution in the presence of different factors were evaluated. The models of Higiro and Tanglertpaibul-Rao were found to be more efficient in determining the intrinsic viscosity of BBG at different temperatures, pH levels, and the presence of salts and sugars. The flexibility index and activation energy of BBG indicated its high flexibility in different environmental conditions, making it a recommended natural thickener for food-related fluids.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2023)
Article
Chemistry, Applied
Zhaomin Zheng, Qilin Huang, Yu Kang, Yonggang Liu, Wei Luo
Summary: The study investigated the influence of molecular size and chain conformation of water-soluble yeast beta-glucan on its interaction with Dectin-1, revealing that higher molecular weight beta-glucan exhibited a spherical conformation while smaller molecular weight beta-glucan showed a stiff chain conformation. The interaction between beta-glucan and Dectin-1 was found to be easier for spherical beta-glucan with longer side chains.
CARBOHYDRATE POLYMERS
(2021)
Article
Nutrition & Dietetics
Marcus Schmidt, Elisabeth Sciurba, Sharline Nikolay, Alexandra Huesken, Inga Smit
Summary: This study investigates the health promoting properties of different molar masses of beta-glucan (BG) extracted from barley varieties. The results show that high molar mass BG has better health benefits, including cholesterol reduction and increased viscosity.
Article
Engineering, Environmental
Amin Piri, Hyeong Rae Kim, Dae Hoon Park, Jungho Hwang
Summary: Airborne virus susceptibility is a major cause of severe respiratory diseases worldwide, emphasizing the need to develop rapid and accurate monitoring and diagnostic approaches for emerging infections. The study found that using a sampling solution of PBS+AA can effectively reduce oxidative damage to viral RNA and protein, thereby increasing virus survivability during sampling.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Wenjin Zhang, Xiaojia Zhang, Qiuxian Bai, Le Liang, Sheng Wang, Lanping Guo
Summary: Polysaccharides are biomolecules that are widely present in nature and have unique nutritional and pharmacological value. The structural diversity of polysaccharides provides a basis for their diverse biological functions, but also poses challenges for their research. This review proposes a downscaled strategy and corresponding technologies based on the receptor-active centre to simplify polysaccharide research. The historical origins, principle verification, and potential future applications of polysaccharide receptor-active centres are discussed.
Article
Engineering, Environmental
Tamika E. van't Hoff, Yuliia Orlova, Rebecca E. Harmon, Piet D. Iedema
Summary: Biopolymers and biopolymer networks formed through autoxidation contain a wide variety of monomeric building blocks, making both modeling and experimental validation challenging. A new model combining automated reaction network generation and random graph modeling is developed to predict global polymer properties. This model was applied to the polymerization of ethyl linoleate and methyl linoleate in linseed oil paint binder, and the predicted mass spectrum of finite connected components was validated with experimental data.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Leon V. T. Bork, Paul Haase, Sascha Rohn, Clemens Kanzler
Summary: This study investigates the reaction between norfuraneol and different carbonyl compounds, as well as the underlying mechanisms. The results show that aldol reactions lead to the formation of carbohydrate-based oligomers, and redox reactions result in an increase in double bonds.
Article
Chemistry, Applied
Leon Bork, Paul T. Haase, Sascha Rohn, Clemens Kanzler
Summary: Chemical reactions of reducing sugars and amino compounds result in the formation of heterogeneous, high molecular weight colorants (melanoidins) with unknown structures. Model experiments using reactive intermediates were conducted to understand the formation mechanisms of colored reaction products. Norfuraneol, a reactive methylene compound, was incubated individually or combined with glyoxal, glycolaldehyde, and acetaldehyde at elevated temperatures. Photometric, chromatographic, and mass spectrometric methods were employed to analyze the colored reaction products and investigate the reactivity of different carbonyls. Aqueous solutions of norfuraneol and glyoxal showed the highest color formation among the model reaction systems, and it was observed that the initial reactants and their degradation products were incorporated into the colorants. The colored oligomers identified in this study were composed of carbohydrate-based intermediates of the Maillard reaction and termed as melanoidin precursors or pre-melanoidins.
Article
Genetics & Heredity
Mengli Zhao, Huitong Zhou, Yuzhu Luo, Jiqing Wang, Jiang Hu, Xiu Liu, Shaobin Li, Kaiwen Zhang, Huimin Zhen, Jon G. H. Hickford
Summary: The KRTAP1-2 gene in goats has been identified and found to have multiple sequence variants that are associated with raw cashmere fiber weight. However, these variants do not affect fiber diameter and length.
Article
Biochemistry & Molecular Biology
Daniele Peterle, Elena S. Klimtchuk, Thomas E. Wales, Florian Georgescauld, Lawreen H. Connors, John R. Engen, Olga Gursky
Summary: This study identifies the N32T substitution in the CRD1 of lambda 6 LC as a driver of amyloid formation, which increases the amyloidogenic propensity of the CDR1 loop and accelerates amyloid growth. The destabilizing effects of N32T propagate across the molecule and impact regions up to 30 angstrom away from the substitution site, suggesting long-range effects of a conservative point substitution in a dynamic surface loop relevant to Ig function. Comparisons between patient-derived and engineered proteins indicate that interactions between N32T and other substitution sites contribute to amyloidosis, highlighting the critical role of CDR1 in amyloid formation by lambda 6 LCs.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Chunmiao Yu, Yesheng Wang, Ruiping Wu, Bingling Li
Summary: In this paper, a reciprocal strategy is proposed that utilizes solid-state nanopores for precise characterization of nucleic acid assembly and utilizes the formed assembly as an amplifier for molecular sensing with highly distinguished and anti-interference signal. The formation of branched assembly structures (BAS) of G-tailed hairpin hybridization chain reaction (HCR) concatemers in a homogeneous solution is demonstrated. These BASs can be controlled to the optimal size to avoid pore blockage and produce a current 14 times higher than conventional double-stranded chains, which serve as an anti-interference signal for small targets.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Jessica S. Y. Ooi, Cher Ryn Lim, Chai Xian Hua, Jeck Fei Ng, Siu Yee New
Summary: This study investigates the effect of DNA hairpins on the stabilization of gold nanoparticles against salt-induced aggregation in label-free colorimetric biosensors. Results showed that longer hairpin stems generally provide better stabilization, and hairpins with toeholds beyond a certain length did not improve stabilization. The stability trend of the hairpins with a homopolymeric toehold was similar to that of ssDNA. Variants with a high proportion of adenine as terminal bases showed stronger stabilization, and the introduction of cytosine or guanine as preceding bases also enhanced stabilization. However, variants with guanine or thymine showed less protection against salt-induced aggregation, especially guanine-rich hairpins that could form G-quadruplexes. These findings can guide researchers in designing suitable DNA hairpins for label-free AuNP-based biosensors.
Review
Food Science & Technology
Gopalsamy Rajiv Gandhi, Varghese Edwin Hillary, Poovathumkal James Antony, Linda L. D. Zhong, Devarajan Yogesh, Neenthamadathil Mohandas Krishnakumar, Stanislaus Antony Ceasar, Ren-You Gan
Summary: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome characterized by dysfunction of pancreatic beta-cells due to genetic and environmental factors. Essential oils derived from dietary plants have been found to have anti-diabetic effects by modulating specific signaling pathways and inflammatory mediators involved in insulin resistance.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Jiani Yang, Ting Gu, Yongtong Lu, Yuejia Xu, Ren-You Gan, Siew Bee Ng, Quancai Sun, Ye Peng
Summary: Osmanthus fragrans, a traditional fragrant plant cultivated in China for over 2,500 years, has gained increasing attention due to its unique aroma and potential health benefits. This review summarizes the aroma and functional components of O. fragrans, discusses their biosynthetic mechanism, and highlights the beneficial functions and related molecular mechanism of O. fragrans extract. Potential applications and future perspectives are also summarized and discussed. Based on current research, O. fragrans extracts and components have great potential to be developed into value-added functional ingredients with preventive effects on certain chronic diseases. However, efficient, large-scale, and commercially viable extraction methods are crucial, along with more clinical studies to explore its beneficial functions and guide its development into functional food products.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Chen Liu, Ren-You Gan, Daiwen Chen, Liang Zheng, Siew Bee Ng, Ivonne M. C. M. Rietjens
Summary: Green tea catechins (GTCs) have various beneficial effects, but their bioavailability is generally low. The majority of ingested GTCs are degraded by gut microbiota, forming low-molecular-weight metabolites. This process improves the bioavailability and enriches the biological activities of GTCs.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Lejaniya Abdul Kalam Saleena, Pui Liew Phing, Ren-You Gan, Anas Al-Nabulsi, Tareq Osaili, Afaf Kamal-Eldin, Mutamed Ayyash
Summary: Fermented dairy products like yogurt and kefir are popular in the MENA region for their unique flavor and potential health benefits. However, traditional production methods lack consistency, making standardization and quality assurance challenging. Despite this, these products are believed to have significant health benefits due to traditional processing methods.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Food Science & Technology
Ming-Yue Li, Yi Liu, Kin Weng Kong, Fang Geng, Hong-Yan Liu, Ren-You Gan
Summary: In this study, different cultivars of broccoli seeds and sprouts were investigated for their metabolites, antioxidant properties, total phenolic content (TPC), and total flavonoid content (TFC). The sprouts of Lv Hua (LH), You Xiu (YX), and Bi Lv (BL) had significant differences in metabolites compared to their respective seeds. The linoleic acid metabolism pathway was found to be significant in all three cultivars. Overall, this study provides scientific support for the selection of broccoli cultivars for germination and product development.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Shahida Anusha Siddiqui, Muhammad Qudrat Ullah Farooqi, Shuva Bhowmik, Zahra Zahra, M. M. Chayan Mahmud, Elham Assadpour, Ren-You Gan, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: Microfluidics and nanofluidics techniques show great potential in encapsulating bioactive compounds in various industries. They offer advantages such as improved stability, bioavailability, and solubility of bioactives, along with controlled release and protection against degradation. However, further studies are needed to fully explore the potential efficacy of these techniques in food processing and encapsulation.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Huan Guo, Yin-Jian Zheng, Ding-Tao Wu, Xu Du, Hong Gao, Mutamed Ayyash, De-Guang Zeng, Hua-Bin Li, Hong-Yan Liu, Ren-You Gan
Summary: China is a major producer of citrus fruits, and Sichuan is one of the major citrus planting bases with a large citrus planting area. However, there is limited information on the functional, nutritional, and qualitative characteristics of different citrus varieties in Sichuan. This study systematically investigated and analyzed 10 typical citrus varieties cultivated in Sichuan, and found significant differences among the varieties in terms of quality attributes, juice properties, mineral elements, and health-promoting nutritional and functional components. The results provide valuable information for the cultivation and selection of nutritious citrus fruits.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Applied
Abdelmoneim H. Ali, Salah A. Kalifa, Ren-You Gan, Nagendra Shah, Mutamed Ayyash
Summary: The fatty acid and amino acid composition of ripened and unripened cheeses produced from different milk sources were investigated in this study. Major fatty acids detected in the cheeses were myristic, palmitic, stearic, and oleic. Each cheese type had a distinctive amino acid profile. These findings have important implications for the dairy industry and food composition analysis.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Food Science & Technology
Ruo-Gu Xiong, Jiahui Li, Jin Cheng, Si-Xia Wu, Si-Yu Huang, Dan-Dan Zhou, Adila Saimaiti, Ao Shang, Guo-Yi Tang, Hua -Bin Li, Ren-You Gan, Yibin Feng
Summary: This paper summarizes the effects of contaminants and food additives on mental health, highlighting that some contaminants and additives may contribute to the occurrence of anxiety, depression, schizophrenia, and attention deficit hyperactivity disorder. Additionally, it discusses the preventive and therapeutic effects of certain dietary components against these mental disorders.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Food Science & Technology
Si-Xia Wu, Ruo-Gu Xiong, Jin Cheng, Xiao-Yu Xu, Guo-Yi Tang, Si-Yu Huang, Dan-Dan Zhou, Adila Saimaiti, Ren-You Gan, Hua-Bin Li
Summary: In this study, kombucha beverages were prepared using golden-flower tea and honeysuckle-flower tea as raw materials. The antioxidant activities, total phenolic contents, concentrations of bioactive components, and sensory scores of the kombucha beverages were assessed. The results showed that both kombucha beverages had strong antioxidant activities and high sensory analysis scores. Fermentation with golden-flower tea residues significantly increased the antioxidant activity and total phenolic contents, while fermentation with honeysuckle tea residues had a minor effect. The concentrations of bioactive compounds could be increased by fermentation with golden-flower tea residues, but fermentation with honeysuckle-flower tea residues had limited effects. The sensory scores of golden-flower tea kombucha and honeysuckle-flower tea kombucha were not significantly affected by fermentation with or without tea residues, and golden-flower tea kombucha had higher sensory scores.
Review
Food Science & Technology
Weicheng Li, Qiong Wu, Lai-yu Kwok, Heping Zhang, Renyou Gan, Zhihong Sun
Summary: This review summarizes the research progress of the population and functional genomics of lactic acid bacteria (LAB). It elucidates the formation mechanism and driving forces of LAB characteristics, highlights the application of LAB genome in food safety and properties, and provides suggestions for improving resource exploitation and application.
Article
Energy & Fuels
Pengfei Yao, Xiaohua Jiang
Summary: This paper analyzes harmonic distortion caused by the narrow pulse problem in matrix converters and proposes an improved switching pattern based on the basic five vector switching pattern. The improved pattern solves the narrow pulse problem by adding an additional zero vector and adjusting the sequence of the four active vectors to minimize switching times. Simulation and experimental results show that the proposed six vector switching pattern reduces low-frequency harmonics, decreases average switching frequency, attenuates sampling frequency harmonics, improves the THD of the output current, and has benefits in both normal and unbalanced input voltage conditions.
CSEE JOURNAL OF POWER AND ENERGY SYSTEMS
(2023)
Article
Engineering, Biomedical
Chunyan Fang, Yaodong You, Fan Luo, Zheng Li, Yifeng Shen, Fangyue Wang, Jingyi Zhang, Ren-You Gan, Yulong Ye
Summary: In this study, a novel drug delivery system (ICA-SNPs) was developed using natural silk fibroin nanoparticles to load icariin (ICA). The system effectively delivered drugs to spermatogonium, enhancing the anti-infertility properties of ICA and mitigating spermatogenesis dysfunction induced by BPA.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Mohammad Tarique, Abdelmoneim H. Ali, Jaleel Kizhakkayil, Ren-You Gan, Shao-Quan Liu, Afaf Kamal-Eldin, Mutamed Ayyash
Summary: The objective of this research was to explore the functional qualities of two EPSs produced by recently discovered LAB (Lactobacillus delbrueckii (EPS-LB3) and Lacticaseibacillus rhamnosus (EPS-MLB3)) that have potential probiotic benefits. The study found that these EPSs have antioxidant, antimicrobial, antibiofilm, and antiproliferative activities, as well as positive effects on the gut microbiome.
FOOD HYDROCOLLOIDS FOR HEALTH
(2023)
Review
Agriculture, Dairy & Animal Science
Andy Wai Kan Yeung, Natalia Ksepka, Maima Matin, Dongdong Wang, Eliana B. Souto, Jivko Stoyanov, Javier Echeverria, Devesh Tewari, Jaroslaw Olav Horbanczuk, Massimo Lucarini, Alessandra Durazzo, Joanna Marchewka, Vasil Pirgozliev, Ren-You Gan, Nikolay T. Tzvetkov, Kamil Wysocki, Farhan Bin Matin, Olena Litvinova, Anupam Bishayee, Hari Prasad Devkota, Amr El-Demerdash, Mladen Brncic, Antonello Santini, Olaf. K. Horbanczuk, Michel-Edwar Mickael, Michal Lawinski, Niranjan Das, Bodrun Naher Siddiquea, Dalibor Hrg, Atanas G. Atanasov
Summary: This study provides a quantitative literature analysis on the influence of diet on non-alcoholic fatty liver disease (NAFLD). The analysis reveals that China and the United States are significant contributors to this field, and key dietary compounds such as resveratrol and polyphenols are frequently mentioned and cited, showing potential benefits for NAFLD in both human and animal studies.
ANIMAL SCIENCE PAPERS AND REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
