Review
Immunology
Ricarda Cortes-Vieyra, Octavio Silva-Garcia, Anel Gomez-Garcia, Sergio Gutierrez-Castellanos, Cleto Alvarez-Aguilar, Victor M. Baizabal-Aguirre
Summary: Understanding the regulation of GSK3 beta activity in inflammatory responses caused by pathogenic microorganisms is crucial for controlling the intensity of inflammation. Recent studies have shown that regulating GSK3 beta activity can reduce the detrimental effects of the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Hui Yue, Yan Li, Mingying Yang, Chuanbin Mao
Summary: T7 phage, with its unique advantages, can be genetically engineered to display foreign peptides or proteins on its capsid for specific targeting, making it promising in various biomedical applications such as imaging, therapeutics, drug and gene delivery, and detection tools.
Article
Biochemistry & Molecular Biology
Saadlee Shehreen, Nils Birkholz, Peter C. Fineran, Chris M. Brown
Summary: Many bacteria use CRISPR-Cas systems to defend against invasive mobile genetic elements, and in response, these genetic elements have developed strategies to resist CRISPR-Cas. This study identified and analyzed Aca and AcrIIA1 homologs in bacterial genomes and demonstrated the widespread conservation of Aca proteins in repressing acr expression.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Microbiology
Hai Xu, Xi Bao, Weiming Hong, Anping Wang, Kaimin Wang, Hongyan Dong, Jibo Hou, Roshini Govinden, Bihua Deng, Hafizah Y. Y. Chenia
Summary: Deletion of gene 17.5 from phage T7 delays lysis time and enlarges burst size, but these characteristics recover to normal levels during serial passage.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nicholas A. Swanson, Ravi K. Lokareddy, Fenglin Li, Chun-Feng David Hou, Sebastian Leptihn, Mikhail Pavlenok, Michael Niederweis, Ruth A. Pumroy, Vera Y. Moiseenkova-Bell, Gino Cingolani
Summary: This study reconstructed the DNA-ejectosome components of phage T7 and solved the structure, revealing the formation of a DNA tube by gp15, an outer membrane pore by gp14, and an extension into the host cytoplasm by gp16. The reconstituted gp15:gp16 complex lacks channel-forming activity, suggesting transient formation of a pore for DNA passage during genome ejection.
Review
Gastroenterology & Hepatology
Han Shuwen, Ding Kefeng
Summary: This review presents the interactions between phages and bacteria in the human intestinal tract, as well as their roles in disease pathogenesis and treatment.
Article
Biochemical Research Methods
John M. Pryor, Vladimir Potapov, Katharina Bilotti, Nilisha Pokhrel, Gregory J. S. Lohman
Summary: This article describes a study on constructing large DNA targets using Golden Gate assembly (GGA) method. Through optimization, they successfully assembled over 50 DNA fragments in a single reaction and applied it to genome construction, obtaining infectious phage particles.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jose Roberto Rodrigues, Scott W. Roy, Ravinder N. M. Sehgal
Summary: Avian haemosporidian parasites can cause malaria-like symptoms and threaten bird species, and recently, new RNA viruses associated with these parasites have been discovered. Analysis of transcriptome data revealed the presence of two novel RNA viruses associated with different genera of avian haemosporidians.
Article
Microbiology
Ning Duan, Mark Radosevich, Jie Zhuang, Jennifer. M. M. DeBruyn, Margaret Staton, Sean. M. M. Schaeffer
Summary: Soil viral infection can impact soil microbial structure and functions, which are vital to global biogeochemical cycling. In long-term conservation agricultural management, viral diversity, community structure, and the correlation with bacteria are influenced by nitrogen fertilization.
Article
Agriculture, Multidisciplinary
Shu-Yun Cheng, Tzu-Han Lin, Po-Ting Chen
Summary: In this study, a powerful T7 expression system was constructed in Escherichia coli Nissle 1917 (EcN) to generate a recombinant protein expression host. By integrating multiple gene expression cassettes and a multiple phage attachment sites (IMPACT) system, more robust and stable gene expression was achieved.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Virology
Mianzhi Wang, Heng Zhu, Jingyi Wei, Li Jiang, Lei Jiang, Ziyi Liu, Ruichao Li, Zhiqiang Wang
Summary: As antimicrobial resistance (AMR) continues to increase, phage therapy has re-emerged as an attractive alternative. In this study, two lytic T4-like and T7-like phages infecting Escherichia coli are selected and the genetic determinants involved in phage susceptibility and resistance are identified. The results of this study provide important insights into the genetic determinants involved in phage infection and can be used to improve phage therapy outcomes in fighting antimicrobial resistance.
Article
Computer Science, Interdisciplinary Applications
Maria Victoria Diaz-Galian, Miguel A. Vega-Rodriguez, Felipe Molina
Summary: Phage therapy is a strategy used to lyse bacteria that cause harm to health. This article introduces an R package called PhageCocktail that automatically designs efficient phage cocktails.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Jun Xi, Yingying Li, Huibin Cheng, Yichao Wang
Summary: This study identified the antigenic epitopes of the acidic chain A2 in glycinin and obtained the epitopes that were destroyed in two common processing methods. It is of great significance to develop application products for rapid detection of de-allergenicity effect of processed food and prevent the occurrence of soybean allergenic diseases.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Andrology
Rachel Guiton, Joel R. Drevet
Summary: Infertility affects one out of six couples worldwide, with male infertility often caused by congenital or acquired factors, including pathogen infections. A systematic review of studies found that viral, bacterial, and parasitic infections can significantly impact the male genital tract, leading to infertility through organ damage, loss of function, or direct damage to sperm cells. These infections can also be transmitted to women and offspring, highlighting the importance of detection, treatment, and prevention measures.
BASIC AND CLINICAL ANDROLOGY
(2023)
Article
Biochemical Research Methods
Chutikarn Chitboonthavisuk, Chun Huai Luo, Phil Huss, Mikayla Fernholz, Srivatsan Raman
Summary: The study demonstrates the construction of a dynamic, controllable infectivity switch in bacteriophage T7 using synthetic transcription repressors, showing that the engineered phage is viable without loss of fitness.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)