期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 112, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2022.109204
关键词
Amomum longiligulare polysaccharide 1; Poly (lactic -co -glycolic acid); Immunomodulatory activity
资金
- Hainan Province Science and Technology Special Fund [KYQD(ZR)1825]
- National Natural Science Foundation of China
- Scientific Research Staring Foundation of Hainan University
- [ZDYF2022XDNY141]
- [32160808]
This study found that ALPP extracted from Amomum longiligulare T.L. Wu fruits has a promoting effect on the activation of macrophages, as well as the proliferation and maturation of T lymphocytes and dendritic cells.
Amomum longiligulare polysaccharide 1 (ALP1) was extracted from Amomum longiligulare T.L. Wu fruits and the poly (lactic-co-glycolic acid) nanoparticle enveloping ALP1 (ALPP) showed a good promoting effect on the activation of macrophages in our previous study. To further understand the immunomodulatory property of ALPP, the effect of ALPP on T lymphocytes and dendritic cells was investigated in the present study. The proliferation rates of chicken T lymphocytes and chicken bone marrow dendritic cells (chBM-DCs) that were treated with ALP1 or ALPP were determined by using MTT method. Meanwhile, the relative mRNA levels of cytokines from T lymphocytes and surface molecules of chBM-DCs were determined by using qRT-PCR method. In addition, the drug uptake capacity of chBM-DCs was also tested. As a result, the promoting effect on the proliferation of T lymphocytes and the Th1-type immune response of ALPP was better than that of ALP1. In addition, ALPP was much more effectively swallowed by chBM-DCs so that its promoting effect on the proliferation and maturation of chBM-DCs was higher than that of ALP1. To conclude, ALPP had a stronger immunomodulatory activity than ALP1, and showed the potential to become a new type of immune booster.
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