期刊
CARBOHYDRATE POLYMERS
卷 133, 期 -, 页码 31-38出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.06.102
关键词
Honokiol; Hydroxypropyl-beta-cyclodextrin; Pectin; Nanoparticle; HepG2
资金
- Natural Science Foundation Project of CQ CSTC [cstc2012jjA10021]
- National Research Foundation for the Doctoral Program of Higher Education of China [20125503120003]
- Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJ120307]
- Chongqing Board of Health Project [2013-2-060]
- Students' Research and Innovation Experimental Project of Chongqing Medical University [201244, 201229, 201217, 201432]
Self-assembled pectin nanoparticles was prepared and evaluated for delivering the hydrophobic drug, honokiol (HK), to HepG2 cells. These hydrophobic drug-loaded nanoparticles were developed without using any surfactant and organic solvent. Hydroxypropyl-beta-cyclodextrin (HCD) was used to fabricate an inclusion complex with HK (HKHCD) to increase the solubility of the drug and thus facilitate its encapsulation and dispersion in the pectin nanoparticles. Investigation of the in vitro release indicated that the drug-loaded nanoparticles exhibited a higher drug release rate than free honokiol and an effective sustained-release. Cytotoxicity, cell apoptosis and cellular uptake studies further confirmed that the pectin nanoparticles with galactose residues generated higher cytotoxicity than free honokiol on HepG2 cells which highly expressed asialoglycoprotein receptors (ASGR). Nevertheless, these findings were not observed in ASGR-negative A549 cells under similar condition. Therefore, pectin nanoparticles demonstrated a specific active targeting ability to ASGR-positive HepG2 cells and could be used as a potential drug carrier for treatment of liver-related tumors.(C) 2015 Elsevier Ltd. All rights reserved.
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