期刊
JOURNAL OF IMMUNOLOGY
卷 196, 期 6, 页码 2439-2443出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1501958
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资金
- German National Academic Foundation (Studienstiftung des Deutschen Volkes)
- Deutsche Forschungsgemeinschaft [SFB704]
Protective immunity against intracellular pathogens involves the induction of robust CTL responses. Vaccination with protein Ags establishes such responses only when combined with immune-stimulatory adjuvants. In this study, we compared different adjuvants and identified triphosphate RNA (3pRNA) as especially effective at inducing CTL responses. 3pRNA sensing required IPS-1/MAVS signaling and induced type I IFN in plasmacytoid dendritic cells and macrophages, with the latter being more important for the adjuvant effect. Type I IFN acted on CD11c(+) cells, especially on CD8 alpha(+) Batf3-dependent dendritic cells. Vaccination with OVA in combination with 3pRNA protected mice from a subsequent OVA-encoding adenovirus infection in a CD8(+) cell-dependent manner and more efficiently than other adjuvants. In summary, 3pRNA is a superior adjuvant for CTL activation and might be useful to facilitate antiviral immunization strategies.
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