Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type–Specific Manner

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

(2015) Yunhao Tan et al.   IMMUNITY

Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2

(2015) Kenji Funami et al.   JOURNAL OF IMMUNOLOGY

CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation

(2015) Dionne C.G. Klein et al.   TRAFFIC

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

(2015) Misako Matsumoto et al.   Nature Communications

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

The Clathrin-Mediated Endocytic Pathway Participates in dsRNA-Induced IFN-  Production

(2014) K. Itoh et al.   JOURNAL OF IMMUNOLOGY

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer

(2013) Tsukasa Seya et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Raftlin: a New Biomarker in Human Sepsis

(2013) Wonhwa Lee et al.   INFLAMMATION

The Small GTPase Arf6 Is Essential for the Tram/Trif Pathway in TLR4 Signaling

(2013) Tim Van Acker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling

(2013) Y. Enokizono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA

(2013) Megumi Tatematsu et al.   Nature Communications

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Inhibition of clathrin/dynamin-dependent internalization interferes with LPS-mediated TRAM–TRIF-dependent signaling pathway

(2012) Yanyan Wang et al.   CELLULAR IMMUNOLOGY

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Production of mouse pups from germline transmission-failed knockout chimeras

(2012) Yoshitaka Fujihara et al.   TRANSGENIC RESEARCH

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation

(2011) Ayako Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What the Myddosome structure tells us about the initiation of innate immunity

(2011) Nicholas J. Gay et al.   TRENDS IN IMMUNOLOGY

Localisation and trafficking of Toll-like receptors: an important mode of regulation

(2010) Anne F McGettrick et al.   CURRENT OPINION IN IMMUNOLOGY

The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

(2010) Harald Husebye et al.   IMMUNITY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses

(2009) Kazuko Saeki et al.   JOURNAL OF IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY