Article
Immunology
Jinjin Cao, Shaoming Wang, Congmin Wei, Hongru Lin, Chen Zhang, Yehui Gao, Zixian Xu, Zhou Cheng, Wan-chun Sun, Hong-bing Wang
Summary: In this study, Agrimophol (AGR) was found to inhibit RANKL-induced osteoclastogenesis through various mechanisms, suggesting its potential as a therapeutic agent against bone lysis diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Ma, Ao-yuan Fan, Zheng Liu, Li-qing Yang, Jun-ming Huang, Zhi-ying Pang, Feng Yin
Summary: Our study compared the effects of icariin and its metabolites on osteoclastogenesis and identified baohuoside I as the most effective compound. Baohuoside I inhibited osteoclast differentiation and bone resorptive activity in a dose-dependent manner. Mechanistically, it achieved this by attenuating the activation of the MAPK and NF-kB pathways and reducing the expression of uPAR. Overall, our study demonstrated that baohuoside I can inhibit osteoclast differentiation and protect against bone loss in postmenopausal osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yin Cheng, Haixia Liu, Jing Li, Yujie Ma, Changheng Song, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang
Summary: Monascin was found to inhibit osteoclastogenesis in RANKL-induced RAW264.7 cells by suppressing MAPKs signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Virology
Chen Li, Wen-Feng He, Long-Xi Li, Jing Chen, Guo-Qing Yang, Hong-Tao Chang, Hui-Min Liu
Summary: ISG15 plays a crucial role in the host antiviral response, as demonstrated by its knockout leading to increased susceptibility to PRV infection and loss of antiviral protection. ISG15 deficiency results in reduced expression of IFN beta and relevant ISGs, and excessive production of proinflammatory cytokines may contribute to pathological damage.
Review
Pharmacology & Pharmacy
Zechao Qu, Bo Zhang, Lingbo Kong, Yining Gong, Mingzhe Feng, Xiangcheng Gao, Dong Wang, Liang Yan
Summary: This paper provides an overview of the molecular mechanisms of osteoclasts in osteolysis-related diseases and the potential of natural plant derivatives and compounds for treating these diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fangxue Zhang, Xiaowei Huang, Yuhan Qi, Zhi Qian, Shuo Ni, Zeyuan Zhong, Xu Zhang, Dejian Li, Baoqing Yu
Summary: The study demonstrated that Juglanin could inhibit osteoclast differentiation by suppressing NFATc1 activity. Further animal experiments showed that Juglanin attenuated bone loss in mice with removed ovaries by suppressing osteoclast function. Overall, Juglanin may play a vital role in preventing postmenopausal osteoporosis by inhibiting the RANKL-induced NF-kappa B signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
John W. Kennedy, P. Monica Tsimbouri, Paul Campsie, Shatakshi Sood, Peter G. Childs, Stuart Reid, Peter S. Young, Dominic R. M. Meek, Carl S. Goodyear, Matthew J. Dalby
Summary: In this study, nanovibrational stimulation was used to reduce osteoclast formation and activity in human mononuclear CD14(+) blood cells, enhance osteogenesis, and reduce osteoclastogenesis in a co-culture of primary human bone marrow stromal cells and bone marrow hematopoietic cells. Akt was identified as a potential mediator, known to be involved in bone differentiation and reduced osteoclast activity. The nanovibrational bioreactor has potential to provide humanized 3D models for drug screening after further validation.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Mingming Zhang, Ming Chen, Yi Li, Man Rao, Duanyang Wang, Zhongqi Wang, Licheng Zhang, Pengbin Yin, Peifu Tang
Summary: Recent evidence has revealed the important role of OPG/RANKL/RANK signaling axis in both bone and muscle tissue, but its effects on muscle atrophy are not well understood. This study found that denervated Opg knockout mice showed improved functional recovery and delayed muscle atrophy. OPG deficiency also led to milder activation of the ubiquitin-proteasome pathway in denervated muscle. Transcriptome sequencing revealed changes in gene expression in denervated muscle from Opg knockout mice, and in vitro experiments showed enhanced differentiation ability of satellite cells from Opg knockout mice.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qi He, Junzheng Yang, Delong Chen, Yejia Li, Dawei Gong, Hui Ge, Zihao Wang, Haibin Wang, Peng Chen
Summary: This study demonstrates for the first time that 12-Deoxyphorbol-13-hexadecanoate (DHD) can inhibit bone resorption associated with osteoporosis through multiple mechanisms, including suppressing osteoclastogenesis, inhibiting signaling pathways, and scavenging reactive oxygen species. Preclinical studies show that DHD can protect bone from loss caused by ovariectomy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuanjiu Lei, Camila Guerra Martinez, Sylvia Torres-Odio, Samantha L. Bell, Christine E. Birdwell, Joshua D. Bryant, Carl W. Tong, Robert O. Watson, Laura Ciaccia West, A. Phillip West
Summary: In the mutator mouse model with mitochondrial DNA instability, aberrant activation of the IFN-I immune axis leads to immunometabolic dysfunction, shortened lifespan, and accelerated aging. Elevated IFN-I signaling suppresses activation of NRF2, increasing oxidative stress and proinflammatory responses, resulting in metabolic dysfunction.
Article
Pharmacology & Pharmacy
Chang-hong Li, Zi-rui Lu, Zhen-da Zhao, Xin-yu Wang, Hui-jie Leng, Yan Niu, Mo-pei Wang
Summary: Nitazoxanide (NTZ) has shown potential in inhibiting osteoclastogenesis and bone loss by modulating the STAT3-NFATc1 signaling pathway. The study found that NTZ suppressed osteoclast formation and activity through inhibition of STAT3 phosphorylation and reduction of NFATc1 expression. NTZ could be a potential alternative treatment for bone destruction-related diseases like osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Yang, Yunhan Ma, Shengnan Yu, Zeyang Lin, Changxiu Yan, Yinan Wang, Qian Yuan, Zhe Meng, Guoliang Yan, Zhengxin Wu, Huamei Tang, Zhihai Peng, Jiyi Huang, Guohong Zhuang
Summary: Acute rejection of transplanted hearts involves oxidative programmed cell death mediated by the immune system. This study found that the newly discovered form of cell death called ferroptosis plays a role in heart transplantation. The deficiency of TIPE2 gene inhibits ferroptosis and reduces heart graft injury. Additionally, TIPE2 deficiency decreases IFN-gamma production in T cells, further restraining ferroptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Huimin Hu, Xiaodong Wang, Yansheng Huang, Baorong He, Jinwen Zhu, Kai Sun, Chaoyang Deng, Yunshan Guo, Dingjun Hao, Bin Jian
Summary: The natural compound obacunone found in citrus fruits can inhibit osteoclast differentiation through modulating the Integrin-FAK-Src pathway, suggesting its potential as a therapeutic candidate for the treatment and prevention of bone diseases such as osteoporosis.
Article
Chemistry, Medicinal
Hai-Wei Chen, Chi-Fen Chen, Pei-Rong Lee, Shuenn-Jium Yiin, Jia-Yun Liang, Jue-Liang Hsu, Chi- Chang, Chi-Liang Chern
Summary: 2,5-dihydroxyacetophenone (DHAP), a phenolic compound in Ganoderma bambusicola, inhibits osteoclastogenesis by inhibiting the NFATc1 signaling pathway.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Ki-Shuk Shim, Dong-Ryun Gu, Youn-Hwan Hwang, Hyun Yang, Jin-Ah Ryuk, Hyunil Ha
Summary: The water extract of Fritillariae thunbergii bulbus (WEFT) has inhibitory effects on osteoclast differentiation and ovariectomy-induced osteoporosis, preventing trabecular loss and fat accumulation.