Article
Biochemistry & Molecular Biology
ChoEen Kim, DucDat Le, Mina Lee
Summary: Species of Podocarpus are traditionally used for various treatments, and diterpenoids isolated from P. macrophyllus show potential anti-inflammatory effects against inflammatory bowel disease.
Article
Biochemistry & Molecular Biology
Fei Li, Xu Jiao, Jing Zhao, Xiaojun Liao, Yunlu Wei, Quanhong Li
Summary: YL-11 EPS has shown the ability to inhibit colon cancer cell proliferation, with in vivo studies confirming its anti-cancer effects and in vitro experiments demonstrating its involvement in regulating mitochondrial pathways and PI3K/AKT signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Shumei Wang, Yi Shan, Shuang Zhang, Lanwei Zhang, Yuehua Jiao, Dijia Xue, Lili Zhang, Huaxi Yi
Summary: In this study, it was found that whole peptidoglycan (WPG) from L. paracasei subsp. paracasei X12, obtained from traditional cheese in northwestern China, inhibited proliferation and induced apoptosis in HT-29 cells in a dose-dependent manner. The induction of apoptosis by WPG was associated with mitochondrial dysfunction and ROS accumulation, as well as the activation of Caspase 3 and alterations in the expression of proapoptotic and antiapoptotic genes. These findings suggest that WPG could potentially be used as a natural agent for cancer treatment.
Article
Cell Biology
Dasa Cizkova, Milan Cizek, Marcela Maloveska, Marta Kmetova, Vladimir Kmet, Dobroslava Bujnakova
Summary: The findings suggest that cell-free L. casei 21L10 supernatant may have potential in attenuating LPS-induced inflammation, inhibiting proliferation, and promoting apoptosis/necrosis. While this study provides insight into using L. casei exoproducts as anti-inflammatory or anti-proliferative agents for gut diseases, further data is required to confirm their efficacy.
Article
Environmental Sciences
Larissa Vivan Cestonaro, Ricieli Pacheco Crestani, Fernanda Mocelin Conte, Yasmin Vendruscolo Piton, Felipe Schmitz, Fernanda Silva Ferreira, Angela T. S. Wyse, Solange Cristina Garcia, Marcelo Dutra Arbo
Summary: This study evaluated the immunomodulatory effect of imidacloprid on macrophages. The results showed that imidacloprid has a concentration-dependent cytotoxic effect on macrophages and affects the cells' inflammatory response and mitochondrial depolarization. These findings suggest that imidacloprid has immunomodulatory effects and mitochondria may regulate innate immune responses in imidacloprid-induced cytotoxicity.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Microbiology
Monique Michels, Gabriel Fernandes Alves Jesus, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Emily Corneo, Paulo Feuser, Daniel Gelain, Felipe Dal-Pizzol
Summary: The discovery of the potential of paraprobiotics to exert different immunological benefits suggests the need for further studies to determine their potential and mechanisms of action in modulating the immune system. This study investigated the immune response of macrophage cell lines, stimulated with lipopolysaccharide, to several microbial-associated molecular patterns (MAMPS) at different doses. The results showed that MAMPS at different doses had varying effects on immune response, and paraprobiotics may contribute to improving intestinal homeostasis, immunomodulation, and host metabolism.
CURRENT MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Su-Jung Hwang, Ye-Seul Song, Hyo-Jong Lee
Summary: Phaseolin, a component of Kushen, has been found to exhibit beneficial effects against inflammation by inhibiting the production of NO and reducing the expression of pro-inflammatory mediators. It also regulates MMP activity, cell adhesion, and leukocyte recruitment, along with inhibiting the nuclear translocation of NF-κB. These findings suggest that phaseolin could be a potential therapeutic candidate for managing inflammation.
Article
Immunology
Raul G. Barletta, John P. Bannantine, Judith R. Stabel, Ezhumalai Muthukrishnan, Dirk K. Anderson, Enakshy Dutta, Vamsi Manthena, Mostafa Hanafy, Denise K. Zinniel
Summary: This study developed a model cell culture system to screen MAP mutants with vaccine potential for apoptosis. The results showed that deletion mutants of MAP strains induced more cell death, consistent with previous experiments on bovine macrophages. These deletion mutants may be good vaccine candidates.
Article
Biotechnology & Applied Microbiology
Hee-Su Jung, Na-Kyoung Lee, Hyun-Dong Paik
Summary: This study aimed to investigate inhibitors of inflammatory reactions. The results showed that heat-killed Lact. sakei CNS001WB and Lact. pentosus WB693 significantly reduced the production of nitric oxide and suppressed the expression of proinflammatory cytokines. Additionally, these strains inhibited the activation of NF-κB and MAPK pathways, and also inhibited the production of reactive oxygen species (ROS). Therefore, it can be concluded that heat-killed Lact. sakei CNS001WB and Lact. pentosus WB693 have anti-inflammatory potential.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biotechnology & Applied Microbiology
Ji Yeon Lee, Ju-Hui Kang, Ye-Rin Jung, Chang-Ho Kang
Summary: This study found that Lactobacillus strains MG4247, MG4272, and MG4577 can alleviate allergic symptoms by modulating cytokines secretion. These strains showed good tolerance and adhesion, and did not exhibit any cytotoxicity in safety evaluation.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Nutrition & Dietetics
Estibaliz Huarte, Concepcion Cid, Amaya Azqueta, Maria-Paz De Pena
Summary: The (poly)phenols from green pepper did not exhibit genoprotective properties against oxidatively generated damage in HT-29 cells at simulated physiological concentrations, regardless of the application of a culinary treatment (griddling). Additionally, high concentrations of (poly)phenolic extracts showed a pro-oxidant effect, even at non-cytotoxic concentrations.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Multidisciplinary Sciences
Phoomjai Sornsenee, Moragot Chatatikun, Watcharapong Mitsuwan, Kantapich Kongpol, Nateelak Kooltheat, Sasirat Sohbenalee, Supawita Pruksaphanrat, Amron Mudpan, Chonticha Romyasamit
Summary: This study evaluated the in vitro antimicrobial effects, antioxidant activity, and anti-inflammatory potential of 10 lyophilized cell-free supernatants of Lactobacillus isolates. The results demonstrated the potential antibacterial and antioxidant properties of the isolates, showing significant inhibition of pathogens and biofilm eradication.
Article
Chemistry, Applied
Shuxin Jiang, Huanan Yin, Xiaohui Qi, Weiguo Song, Weiwei Shi, Jiaojiao Mou, Jie Yang
Summary: Fucosylated chondroitin sulfate from Stichopus chloronotus has immune activation effects on RAW 264.7 macrophages, promoting cell activity and cytokine production. This potentially promising immunomodulator may improve macrophage function through NF-kappa B pathway.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Carina Ade, Xiaomin Qian, Edit Brodszkij, Paula De Dios Andres, Jarvi Spanjers, Isabella N. Westensee, Brigitte Stadler
Summary: This study compared the interaction ability of two structural scaffolds for artificial organelles with macrophage-like cells. It was found that assemblies containing DOPE lipids or GALA could escape lysosomes, providing a fundamental understanding for the development of intracellular nanoreactors.
Article
Plant Sciences
Yuanru Zheng, Chunyang Tian, Chunlin Fan, Nishan Xu, Junjie Xiao, Xiaoyang Zhao, Zibin Lu, Huihui Cao, Junshan Liu, Linzhong Yu
Summary: This study found that Sheng-Mai Yin has significant anti-inflammatory effects, potentially achieved through inhibiting the NF-kappa B and STAT3 signal pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Wanglong Gou, Liang Yue, Xin-yi Tang, Yan-yan Wu, Xue Cai, Menglei Shuai, Zelei Miao, Yuanqing Fu, Hao Chen, Zengliang Jiang, Jiali Wang, Yunyi Tian, Congmei Xiao, Nan Xiang, Zhen Wu, Yu-ming Chen, Tiannan Guo, Ju-Sheng Zheng
Summary: This study identified proteomic biomarkers for incident T2D among Chinese populations and found seven proteins associated with T2D. The research also indicated a potential synergistic interaction between dietary factors such as red meat intake and these biomarkers in exaggerating the risk of T2D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Yixing Yu, Manli Zong, Lifeng Lao, Jianzhu Wen, Daodong Pan, Zhen Wu
Summary: This paper summarizes the adhesion properties of cell surface proteins derived from Lactobacillus strains in recent studies and provides valuable information on the effect of quorum sensing on the adhesion property of Lactobacillus strains in the gastrointestinal environment.
Article
Biochemistry & Molecular Biology
Hai Xu, Lifeng Lao, Chunyu Ji, Qianqian Lu, Yuxing Guo, Daodong Pan, Zhen Wu
Summary: In this study, the LPxTG-motif protein derived from L.reuteri was found to enhance the adhesion characteristics and intestinal survival rate of L.reuteri, as well as promote the signaling molecule production in Lactobacillus strains. Additionally, the LPxTG-motif protein exhibited anti-inflammatory activity by inhibiting the expressions of inflammatory cytokines TNF-alpha and IL-1 beta through MAPK signaling cascades. These findings provide insights into the multifunctional role of LPxTG-motif surface protein derived from L.reuteri in the gastrointestinal tract environment.
MOLECULAR IMMUNOLOGY
(2022)
Article
Food Science & Technology
Qiang Xia, Changyu Zhou, Zhen Wu, Daodong Pan, Jinxuan Cao
Summary: Processomics is a method that combines chemical fingerprinting and kinetic modeling for quality evaluation in food processing and preservation. Currently, it mainly focuses on volatile compounds, resulting in biases. This study proposes the integration of other omics technology platforms to provide a comprehensive analysis of variations in chemical fingerprinting, and the establishment of kinetic mechanistic models to indicate quality-related reactions. Additionally, sensomics can be introduced as a special dimension for quality assessment.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Microbiology
Jianzhu Wen, Yixing Yu, Mengqi Chen, Lei Cui, Qiang Xia, Xiaoqun Zeng, Yuxing Guo, Daodong Pan, Zhen Wu
Summary: This study investigated the tolerance, adhesion ability, and biofilm formation of a Lactobacillus strain in a coculture system using various methods. The results showed that the coculture system promoted the release of signal molecules and protected the viability of Lactobacillus acidophilus in the gastrointestinal environment. Additionally, an amino acid-derived metabolite was found to enhance cell communication and increase the tolerance ability of L. acidophilus.
MICROBIOLOGY SPECTRUM
(2022)
Article
Food Science & Technology
Qianqian Lu, Yingqi Guo, Guo Yang, Lei Cui, Zhen Wu, Xiaoqun Zeng, Daodong Pan, Zhendong Cai
Summary: LTA molecules derived from different Lactobacillus strains exhibit heterogeneity and contribute to the distinguishable adhesion properties of Lactobacillus strains. These LTAs can alleviate inflammatory responses and block certain inflammatory pathways, making them potential alternative therapeutics for ulcerative colitis treatment.
Article
Nutrition & Dietetics
Zhendong Cai, Guowei Zhong, Qianqian Liu, Xingqiao Yang, Xiaoxia Zhang, Song Zhou, Xiaoqun Zeng, Zhen Wu, Daodong Pan
Summary: This study constructed a two-tube hexaplex PCR method for accurate molecular authentication of twelve meat species. The method showed specificity, sensitivity, and reproducibility, and was suitable for food inspection. It was successfully applied to detect meat frauds in commercial meat products.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Fengxuan Lang, Jianzhu Wen, Zhen Wu, Daodong Pan, Linjun Wang
Summary: Lactic acid bacteria fermentation is a simple and safe method of food preservation. Using probiotics in yoghurt can improve the flavor, texture, and health benefits of dairy products. This study found that the mixed culture condition enhanced the texture properties of yoghurt, and L. plantarum A3 fermented yoghurt accumulated additional components that led to significant sensory differences. These results suggest that L. plantarum A3 is a potential probiotic strain that enhances the sensory and nutritional properties of fermented milk.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biotechnology & Applied Microbiology
Chaoran Xia, Xiaoqun Zeng, Liuyang Peng, Daodong Pan, Zhen Wu, Yuxing Guo, Zhendong Cai
Summary: This study investigated the role of UGPase in the freeze-drying survival rate of Staphylococcus carnosus. Overexpression of UGPase increased its activity but decreased the survival rate. The expression levels of genes involved in carbohydrate and amino acid metabolism were significantly altered, affecting the physiological characteristics and survival rate of S. carnosus.
ANNALS OF MICROBIOLOGY
(2022)
Review
Food Science & Technology
Xiankang Fan, Xiefei Li, Lihui Du, Jianhao Li, Jue Xu, Zihang Shi, Chunwei Li, Maoling Tu, Xiaoqun Zeng, Zhen Wu, Daodong Pan
Summary: This paper reviews the effects, mechanisms, and research methods of using natural plant-based homogenates (NPBH) as additives to improve the quality of yogurt. NPBH promotes the growth of lactic acid bacteria, affects the texture and flavor of yogurt, and enhances its nutritional value. Future research could focus on adding Chinese herbs with various health benefits to yogurt, and investigating the clinical implications of NPBH yogurt.
Article
Nutrition & Dietetics
Yan Cheng, Sha Wang, Shilong Ju, Song Zhou, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Guowei Zhong, Zhendong Cai
Summary: A multiplex PCR method has been developed for the molecular authentication of seven different species of meat. The method is highly accurate and reproducible, making it suitable for various meat samples. This technology is of great significance for addressing the issue of meat adulteration.
Article
Nutrition & Dietetics
Jue Xu, Yingyan Chen, Xiankang Fan, Zihang Shi, Mingzhen Liu, Xiaoqun Zeng, Zhen Wu, Daodong Pan
Summary: This study screened LAB with antioxidant capacity, prepared corn fermented milk with antioxidant capacity, and extracted two new peptides with antioxidant capacity. The research provides new ideas and basis for the development of functional dairy products.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Xiaofeng Ji, Tao Deng, Yingping Xiao, Canghong Jin, Wentao Lyu, Zhen Wu, Wen Wang, Xiaoli Wang, Qinfang He, Hua Yang
Summary: Emerging Alternaria and Fusarium mycotoxins in tomatoes and derived tomato products pose potential health risks to humans. This study developed a method for simultaneous quantification of these mycotoxins in tomatoes and their products. The results showed that mycotoxins were detected in various tomato products, with the highest contamination levels found in tomato powders. Children may have higher dietary exposure to these mycotoxins compared to adults. The presence of these mycotoxins in derived tomato products may be a health concern, especially for children and those consuming a high amount of these products.
Article
Agriculture, Multidisciplinary
Weimei Kong, Junai Gan, Mi Su, Binyi Xiong, Xiaoxiao Jiang, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Yangying Sun, Daodong Pan, Qing Liu, Nan Ling, Yuxing Guo
Summary: This study investigated the functional domains of the S-layer protein in Lactobacillus acidophilus CICC 6074, identifying the C-terminal domain as the binding region and the cell wall-anchored receptor as teichoic acid. N-terminal truncations of the protein were found to self-assemble into liposomes and were responsible for cell adhesion.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Lingyu Kong, Yuze Huang, Xiaoqun Zeng, Congyan Ye, Zhen Wu, Yuxing Guo, Daodong Pan
Summary: Galactosyltransferase (GalT) is an important enzyme in EPS synthesis, improving freeze-drying resistance in lactic acid bacteria. The study shows that GalT regulates membrane transport system, sugar metabolism, and quorum sensing to enhance EPS biosynthesis.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
