Article
Microbiology
Koichi Toyoda, Masayuki Inui
Summary: When transitioning from exponential to stationary growth phases, bacterial metabolism shifts from aerobic respiration to fermentation in response to limited oxygen availability. The ldhA gene in Corynebacterium glutamicum encodes l-lactate dehydrogenase, responsible for l-lactate production, and is controlled by transcription regulators SugR, LldR, and GlxR. GlxR has been shown to act as a transcriptional activator of ldhA, affecting both its promoter activity and l-lactate production.
Article
Medicine, General & Internal
Chujun Li, Jinfang Liu, Lu Jiang, Jun Xu, Anjing Ren, Yu Lin, Gang Yao
Summary: The study aimed to investigate the value of MIA and LDH in the prognosis of acral malignant melanoma. The results showed that MIA was an independent risk factor for acral malignant melanoma patients, while there was no association between LDH and melanoma stage and risk.
Article
Multidisciplinary Sciences
Pavithra Viswanath, Georgios Batsios, Joydeep Mukherjee, Anne Marie Gillespie, Peder E. Z. Larson, H. Artee Luchman, Joanna J. Phillips, Joseph F. Costello, Russell O. Pieper, Sabrina M. Ronen
Summary: Telomerase expression and the alternative lengthening of telomeres pathway are correlated with metabolic signatures detectable by metabolic imaging in primary brain tumors, suggesting they can be used to non-invasively monitor telomere maintenance in brain tumors. The authors have identified metabolic biomarkers of TERT and ALT status that can improve tumor diagnosis and treatment response monitoring.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Jing Wu, Yan Chen, Yingying Lin, Fenghua Lan, Zhaolei Cui
Summary: A unique lactate dehydrogenase isoenzyme, LDH-C4, is found in mammalian mature testis and spermatozoa. It plays a critical role in sperm motility, capacitation, and fertilization by being closely related to spermatic energy metabolism. Defects in its catalytic activity are key to pathophysiological abnormalities underlying infertility. Recent studies have also identified LDH-C4 as a cancer-testis antigen due to its aberrant transcription in a broad spectrum of human neoplasms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Renata Poteska, Kambiz Rahbar, Axel Semjonow, Andres Jan Schrader, Martin Boegemann, Katrin Schlack
Summary: This study found that dynamic changes of ALP (non-rise) and LDH (normalization) during treatment with Enzalutamide may be associated with clinical benefit, better progression-free survival (PFS), and overall survival (OS) in patients with bone metastatic castration-resistant prostate cancer (bmCRPC) who do not show a sufficient initial decline in PSA.
Article
Multidisciplinary Sciences
Amanda A. van Vliet, Ella Peters, Denise Vodegel, Danielle Steenmans, Monica Raimo, Susan Gibbs, Tanja D. de Gruijl, Adil D. Duru, Jan Spanholtz, Anna-Maria Georgoudaki
Summary: UCB CD34(+) progenitor cell-derived NK cells showed efficient cytotoxicity against melanoma cells, and this performance was consistent among different UCB donors and correlated with the levels of IFNg, TNF, perforin and granzyme B. Perforin and granzyme B levels predicted NK cell cytotoxic capacity. The involvement of multiple activating receptors, especially TRAIL, was identified as the mode of action for the synergistic cytotoxic NK cell activity.
Article
Multidisciplinary Sciences
Greg M. Allen, Nicholas W. Frankel, Nishith R. Reddy, Hersh K. Bhargava, Maia A. Yoshida, Sierra R. Stark, Megan Purl, Jungmin Lee, Jacqueline L. Yee, Wei Yu, Aileen W. Li, K. Christopher Garcia, Hana El-Samad, Kole T. Roybal, Matthew H. Spitzer, Wendell A. Lim
Summary: In this study, we engineered circuits in CAR T cells to locally induce production of the cytokine IL-2 using tumor-specific synNotch receptors. These circuits enhance CAR T cell infiltration and clearance of immunosuppressive tumors, without causing systemic toxicity. The most effective IL-2 induction circuit acts in an autocrine and TCR- or CAR-independent manner, bypassing key tumor suppression mechanisms.
Article
Food Science & Technology
Sholeh Feizi, Shari Javadiyan, Clare M. Cooksley, Gohar Shaghayegh, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde
Summary: The safety of previously fabricated green synthetized colloidal silver (GSCS) on primary human nasal epithelial cells was evaluated, showing that it has no toxic effects and does not significantly impact the structure and function of the epithelial barrier.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Wei Peng, Jin Chen, Yanping Xiao, Guangjian Su, Yan Chen, Zhaolei Cui
Summary: The upregulation of LDHC/LDH-C4 expression in LUAD is associated with clinical characteristics and prognosis. LDHC has potential clinical applications in the diagnosis of LUAD, serving as a biomarker for diagnosis, efficacy evaluation, and recurrence monitoring.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sofie H. Tolmeijer, Rutger H. T. Koornstra, Jan Willem B. de Groot, Maartje J. Geerlings, Dirk H. van Rens, Marye J. Boers-Sonderen, Jack A. Schalken, Winald R. Gerritsen, Marjolijn J. L. Ligtenberg, Niven Mehra
Summary: For patients with metastatic melanoma, rapid BRAF mutation assessment is crucial, with ctDNA proving to be a reliable alternative to tissue-based testing. Monitoring disease progression and treatment response through ctDNA levels is superior to other blood-based biomarkers, showing promise for diagnostic and monitoring purposes.
Article
Biochemistry & Molecular Biology
Iwona Nowak, Anna A. Brozyna, Marzena Zablocka, Sebastian Student, Malgorzata Durbas, Beata Bugara, Hanna Rokita
Summary: The study showed decreased expression of MCPIP1 in melanoma tumors, with a positive correlation between high ribonuclease expression and melanoma-specific survival of patients. Ectopic expression of MCPIP1 in melanoma cells led to a broad range of alterations in the transcriptome, proteome, and intracellular signaling, indicating MCPIP1-dependent cell cycle arrest and inhibition of Akt/mTOR signaling. Additionally, MCPIP1 overexpression downregulated miRNA-193a-3p expression in melanoma cells, with most effects dependent on the ribonucleolytic activity of the protein. The data suggests a potential tumor suppressor role and positive prognostic marker in melanoma.
MOLECULAR CARCINOGENESIS
(2021)
Article
Endocrinology & Metabolism
Yuni Hisbiyah, Anang Endaryanto, Bagus Setyoboedi, Nur Rochmah, Muhammad Faizi, Katherine Fedora
Summary: This study finds that low selenium levels are associated with autoimmune thyroid disease (AITD) in children with Down syndrome. The levels of selenoprotein-P (SePP) and glutathione peroxidase-3 (GPx3) are correlated with AITD. Therefore, it is recommended to increase selenium levels through the consumption of selenium-rich foods to reduce the risks of AITD and thyroid dysfunction in children with Down syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Ines Pires da Silva, Tasnia Ahmed, Jennifer L. McQuade, Caroline A. Nebhan, John J. Park, Judith M. Versluis, Patricio Serra-Bellver, Yasir Khan, Tim Slattery, Honey K. Oberoi, Selma Ugurel, Lauren E. Haydu, Rudolf Herbst, Jochen Utikal, Claudia Pfoehler, Patrick Terheyden, Michael Weichenthal, Ralf Gutzmer, Peter Mohr, Rajat Rai, Jessica L. Smith, Richard A. Scolyer, Ana M. Arance, Lisa Pickering, James Larkin, Paul Lorigan, Christian U. Blank, Dirk Schadendorf, Michael A. Davies, Matteo S. Carlino, Douglas B. Johnson, Georgina V. Long, Serigne N. Lo, Alexander M. Menzies
Summary: This study aimed to build multivariable predictive models for response and survival outcomes in metastatic melanoma patients treated with immunotherapy. By analyzing clinical characteristics and baseline blood parameters, the final models for predicting treatment response, progression-free survival, and overall survival were developed and nomogram calculators were created.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Yongchao Zhang, Bozhi Liu, Sergei Kotenko, Wei Li
Summary: This meta-analysis examined the prognostic role of neutrophil-to-lymphocyte ratio (NLR) and serum lactate dehydrogenase (LDH) levels in melanoma patients treated with immune checkpoint inhibitors (ICIs). The results showed that high pretreatment NLR and LDH levels were associated with poor overall survival (OS) and progression-free survival (PFS). NLR and LDH levels have the potential to be used as early prognostic biomarkers in melanoma patients treated with ICIs.
Article
Immunology
Nicole J. Toney, Margaret E. Gatti -Mays, Nicholas P. Tschernia, Julius Strauss, James L. Gulley, Jeffrey Schlom, Renee N. Donahue
Summary: The immunocytokine NHS-IL12 delivers IL-12 to the tumor microenvironment and shows promising effect on immune activation at different dosing regimens. Higher doses of NHS-IL12 and more frequent treatments resulted in greater immune activation, as indicated by increased levels of pro-inflammatory analytes, frequencies of immune cells, and favorable clinical response. These findings provide guidance for future clinical studies of NHS-IL12 as monotherapy or in combination therapies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
