Article
Medicine, Research & Experimental
Eric M. Anderson, Michael Luu, Diana J. Lu, Eric M. Chung, Christopher Gay, Kevin S. Scher, Alain C. Mita, Jon Mallen-St Clair, Allen S. Ho, Zachary S. Zumsteg
Summary: The study confirms that lymphovascular invasion and histologic grade are the strongest predictors of neck lymph node metastasis in cN0 patients with pharynx and larynx cancer. Neck dissection is still necessary for cN0 patients to identify the risk of lymph node metastasis even in the modern era.
Article
Dermatology
Lukas Kofler, Katrin Kofler, Claudia Schulz, Helmut Breuninger, Hans-Martin Haefner
Summary: This study analyzed the role of Sentinel lymph node biopsy (SLNB) in assessing lymph node status and survival in high-risk squamous cell carcinoma patients. The results showed that although SLNB is suitable for determining lymph node status, it did not provide any benefit regarding further metastasis or tumor-specific survival.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Review
Otorhinolaryngology
Sophie S. Jang, Morgan E. Davis, David R. Vera, Stephen Y. Lai, Theresa W. Guo
Summary: Sentinel lymph node biopsy has potential clinical utility in the treatment of early stage oral cavity squamous cell carcinoma, but its application should be evaluated in conjunction with factors such as depth of invasion, nodal mapping, and histopathology methods.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Christian Doll, Simon Bigus, Elena Hofmann, Friedrich Mrosk, Claudius Steffen, Felix Thiele, Jan Voss, Kilian Kreutzer, Holger Amthauer, Max Heiland, Steffen Koerdt
Summary: The potential of sentinel lymph node biopsy (SLNB) in patients with recurrent or secondary oral squamous cell carcinoma (OSCC) without clinical signs of lymph node metastases (cN0) was evaluated in this retrospective study. Results showed a detection rate of 88.2% for sentinel lymph nodes, with two cases showing positive SLN. The SLNB had a negative predictive value of 86.7% and a sensitivity of 50.0% as a neck staging procedure.
Article
Medicine, General & Internal
Christian Doll, Claudius Steffen, Holger Amthauer, Nadine Thieme, Thomas Elgeti, Kai Huang, Kilian Kreutzer, Steffen Koerdt, Max Heiland, Benedicta Beck-Broichsitter
Summary: Management of neck in early-stage, clinically node-negative oral squamous cell carcinoma (OSCC) patients remains controversial. This study demonstrated that SLNB using Tc-99m-tilmanocept in a two-day protocol is a reliable and safe staging method for such patients, with no local or nodal recurrences observed in the follow-up period.
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
Brenna E. Swift, Melissa Tigert, Andra Nica, Al Covens, Danielle Vicus, Carlos Parra-Herran, Rachel Kupets, Raymond Osborne, Lilian T. Gien
Summary: This study assessed the accuracy of intraoperative pathologic examination in vulva cancer patients and evaluated patient outcomes. The results showed that intraoperative assessment of sentinel lymph nodes can accurately determine the need for lymphadenectomy and does not compromise patient outcomes.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Roman Ludwig, Jean-Marc Hoffmann, Bertrand Pouymayou, Martina Broglie Dappen, Gregoire Morand, Matthias Guckenberger, Vincent Gregoire, Panagiotis Balermpas, Jan Unkelbach
Summary: This study investigated the lymphatic progression patterns in head and neck squamous cell carcinomas (HNSCC) and analyzed the risk of metastases in different lymph node levels (LNL) based on the involvement of upstream LNLs, T-category, HPV status, and other risk factors. The findings provide valuable insights for the personalization of CTV-N definition in the future.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Otorhinolaryngology
Dongbin Ahn, Gil Joon Lee, Jin Ho Sohn
Summary: Percutaneous US-FNAB/CNB offers significant benefits in terms of time and cost over DLB for the diagnosis of LHSCC, with no major complications occurring.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Laurence Bauwens, Aline Baltres, Danny-Joe Fiani, Philippe Zrounba, Guillaume Buiret, Bertrand Fleury, Nazim Benzerdjeb, Vincent Gregoire
Summary: The study aimed to compare the prevalence and distribution of neck node metastases in HPV+ and HPV- oropharyngeal squamous cell carcinoma patients, showing a higher rate of metastases in the HPV+ group.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Jonathan A. Harounian, Nicole Molin, Thomas J. Galloway, Drew Ridge Facs, Jessica Bauman, Jeffrey Farma, Sanjay Reddy, Miriam N. Lango
Summary: This study found that Merkel cell carcinoma patients with lymphovascular invasion (LVI) and positive sentinel lymph node (SLN) had worse prognostic outcomes. Sentinel lymph node biopsy assists in risk stratification and radiation treatment planning in MCC.
Article
Otorhinolaryngology
Leandro Luongo Matos, Renato Castro Capuzzo, Paola Andrea Galbiatti Pedruzzi, Terence Farias, Jose Wilson Mourao de Farias, Carlos Takahiro Chone, Hugo Fontan Kohler, Jose Guilherme Vartanian, Fernando Luiz Dias, Eduardo Vieira Couto, Fabio Roberto Pinto, Andre Lopes Carvalho, Luiz Paulo Kowalski
Summary: In a real-world scenario, sentinel lymph node biopsy is shown to be accurate and safe for patients with early lip and oral cavity squamous cell carcinoma, with similar results to elective neck dissection.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Andrea Costantino, Claudio Sampieri, Francesca Pirola, Da Hee Kim, Kyuin Lee, Young Min Park, Armando De Virgilio, Se-Heon Kim
Summary: This retrospective cohort study aimed to determine if positive and close surgical margins are associated with worse prognosis in patients who underwent transoral robotic surgery after neoadjuvant chemotherapy. The results showed that positive margins were not independently predictive of tumor control and survival. A threshold of 1.25 mm was identified as the most appropriate to define close margins, but no difference was measured between close and wide negative margins.
Article
Pharmacology & Pharmacy
I Jankovic, P. Kovacevic, D. Jankovic, G. Stevanovic, S. Momcilovic
Summary: The study examined the lymphatic drainage patterns in relation to primary tumor localization in high-risk cutaneous head and neck squamous cell carcinoma (HNSCC). Results of sentinel lymph node (SLN) biopsy showed regularities of metastasis, providing insights for constructing a lymphatic drainage map and predicting potential metastatic sites.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Giri Krishnan, Nynke S. van den Berg, Naoki Nishio, Georgina Juniper, Jaqueline Pei, Quan Zhou, Guolan Lu, Yu-Jin Lee, Kimberly Ramos, Andrei H. Iagaru, Fred M. Baik, Alexander D. Colevas, Brock A. Martin, Eben L. Rosenthal
Summary: The study showed that intravenous infusion of a tumor-targeted tracer could accurately identify sentinel and metastatic lymph nodes, potentially improving the practice of SLNB surgery.
Article
Surgery
Elise A. J. de Savornin Lohman, T. J. J. de Bitter, G. Hannink, M. F. T. Wietsma, E. Vink-Borger, I. D. Nagtegaal, T. J. Hugh, A. J. Gill, N. Bhimani, M. Seyed Ahadi, R. S. van der Post, Philip R. de Reuver
Summary: The study aimed to develop and validate a clinical prediction model for overall survival in patients with nonmetastatic, resected gallbladder cancer (GBC). Data from a Dutch cohort was used for development and an Australian cohort for external validation. The proposed model demonstrated superior discriminatory capacity compared to the AJCC staging system and can be a useful tool for physicians and patients.
Article
Orthopedics
Martijn F. L. Kuijpers, Gerjon Hannink, Liza N. van Steenbergen, B. Wim Schreurs
Summary: In young patients in the Netherlands, there has been a significant change in the method of fixation between primary and revision THA, especially in acetabular revisions. There is no significant difference in short-term survival between revision procedures that changed or did not change in method of fixation.
Article
Oncology
Yvonne Koop, Arco J. Teske, Iris Wanders, Hanneke Meijer, J. H. A. M. (Hans) Kaanders, Olivier C. Manintveld, H. Carlijne Hassing, Hester Vermeulen, Angela H. E. M. Maas, Dick-Johan van Spronsen, Femke Atsma, Saloua El Messaoudi
Summary: This study evaluated current perspectives on cardio-oncology and found that professionals have limited awareness and knowledge of cardio-oncology guidelines, leading to insufficient treatment for cardio-oncology patients. There is a strong need for additional training and practical guidelines in this field.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Health Care Sciences & Services
Evelien B. B. van Well, Stan R. W. Wijn, Gerjon Hannink, Janneke P. C. Grutters, Maroeska M. M. Rovers
Summary: Numerous studies have shown that arthroscopic partial meniscectomy (APM) is not (cost-) effective in patients with symptoms attributed to a degenerative meniscus tear. The study found that not performing APM to treat degenerative meniscus tears in the Netherlands can significantly reduce healthcare expenditures by €54 million. Therefore, it is recommended to further reduce the use of APM for this condition.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2023)
Review
Orthopedics
S. R. W. Wijn, G. Hannink, H. Osteras, M. A. Risberg, E. M. Roos, K. B. Hare, V. A. van de Graaf, R. W. Poolman, H. -W. Ahn, J. -K. Seon, M. Englund, M. M. Rovers
Summary: The objective of this study was to identify subgroups of patients with MRI-confirmed degenerative meniscus tears who may benefit from APM compared to non-surgical or sham treatment. The results showed a small improvement in knee pain for the APM group compared to the non-surgical or sham group at 24 months follow-up. However, there were no significant differences in overall knee function and health-related quality of life between the two groups. No relevant subgroup of patients who benefitted from APM was identified.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Review
Oncology
Juan P. Rodrigo, Mario Sanchez-Canteli, Asterios Triantafyllou, Remco de Bree, Antti A. Maekitie, Alessandro Franchi, Henrik Hellquist, Nabil F. Saba, Goeran Stenman, Robert P. Takes, Cristina Valero, Nina Zidar, Alfio Ferlito
Summary: Neutrophil-to-lymphocyte ratio (NLR) has been associated with prognosis in various cancers, including head and neck cancer. However, its prognostic value in oropharyngeal carcinomas (OPSCC), especially in relation to HPV status, is limited. This meta-analysis shows that an elevated pretreatment NLR is associated with worse outcomes in OPSCC, specifically in HPV-positive cases. NLR could serve as an affordable prognostic marker in HPV-positive OPSCC.
Review
Biochemistry & Molecular Biology
Carlos M. Chiesa-Estomba, Miguel Mayo-Yanez, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Robert P. Takes, Remco de Bree, Gyorgy B. Halmos, Nabil F. Saba, Sandra Nuyts, Alfio Ferlito
Summary: Radiomics is a promising tool for the diagnosis, treatment, and follow-up of patients with hypopharyngeal squamous cell carcinoma (HPSCC). Further large-scale prospective studies are needed to validate its effectiveness in this patient population.
Article
Oncology
Johannes H. A. . M. Kaanders, Johan Bussink, Erik H. J. G. Aarntzen, Petra Braam, Heidi Rutten, Richard W. M. van der Maazen, Marcel Verheij, Sven van den Bosch
Summary: PET imaging with [18F]FDG-PET has proven value in the management of malignant diseases, and has potential for individualized radiotherapy dose prescription. This review discusses the current status, progress, and future expectations of [18F]FDG-PET in individualized radiotherapy for various tumor types.
SEMINARS IN RADIATION ONCOLOGY
(2023)
Article
Economics
Mirre Scholte, Jan Heidkamp, Gerjon Hannink, Janneke P. C. Grutters, Maroeska M. Rovers
Summary: This study examines the use of care pathway analysis to identify unmet needs for innovative solutions in disease contexts. The analysis focuses on oncologic surgery and reveals the highest percentages of inadequate margins in oral cavity cancer, glioblastoma, and pancreatic cancer. The study suggests that care pathway analysis can provide valuable insights for stakeholders involved in prioritizing areas in need of innovation.
Article
Surgery
Sanne Lof, Linda Claassen, Gerjon Hannink, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando Burdio, Giovanni Butturini, Giovanni Capretti, Riccardo Casadei, Safi Dokmak, Bjorn Edwin, Alessandro Esposito, Jean M. Fabre, Giovanni Ferrari, Asmund A. Fretland, Fadhel S. Fteriche, Giuseppe K. Fusai, Alessandro Giardino, Bas Groot Koerkamp, Mathieu D'Hondt, Asif Jah, Sivesh K. Kamarajah, Emanuele F. Kauffmann, Tobias Keck, Stijn van Laarhoven, Alberto Manzoni, Marco V. Marino, Ravi Marudanayagam, Izaak Q. Molenaar, Patrick Pessaux, Edoardo Rosso, Roberto Salvia, Zahir Soonawalla, Regis Souche, Steven White, Frans van Workum, Alessandro Zerbi, Camiel Rosman, Martijn W. J. Stommel, Mohammed Abu Hilal, Marc G. Besselink
Summary: Understanding the learning curve of MIDP is important in reducing patient harm. This multicenter study analyzed data from 26 European centers to evaluate the length of the learning curve. The findings suggest that 85 procedures are needed to achieve optimal outcomes, while earlier mastery can be achieved for conversion rate, operation time, and intraoperative blood loss.
Article
Oncology
Margot A. Stone, Birgit I. Lissenberg-Witte, Remco de Bree, Jose A. Hardillo, Femke Lamers, Johannes A. Langendijk, C. Rene Leemans, Robert P. Takes, Femke Jansen, Irma M. Verdonck-de Leeuw
Summary: This study investigated changes in sexuality and sexual dysfunction in head and neck cancer patients in the first two years after treatment, specifically looking at the impact of different treatments. Results showed that patients treated with chemoradiation experienced a deterioration in sexuality and sexual dysfunction, with differences observed between men and women. Men reported changes in erectile function, orgasm, satisfaction with intercourse, and overall satisfaction, while women reported changes in desire, arousal, and orgasm. These findings provide important information for improving sexual care for head and neck cancer patients.
Article
Oncology
Caroline M. Speksnijder, Lucia Ortiz-Comino, Anton F. J. de Haan, Carolina Fernandez-Lao, Remco de Bree, Matthias A. W. Merkx
Summary: This study aimed to identify factors related to swallowing function up to 5 years after oral cancer treatment. It was found that patients who are older at diagnosis, women, and patients who regularly consume alcohol before their treatment may have poorer swallow functioning after oral cancer treatment. Patients that fit these criteria should have their swallowing evaluated during clinical follow-ups and sent to swallowing therapy when needed. Attention to optimizing tongue function is crucial during therapy to maintain an optimal swallowing function.
Review
Biochemistry & Molecular Biology
Karthik Nagaraja Rao, Prathamesh S. Pai, Prajwal Dange, Luiz P. Kowalski, Primoz Strojan, Antti A. Makitie, Orlando Guntinas-Lichius, K. Thomas Robbins, Juan P. Rodrigo, Avraham Eisbruch, Robert P. Takes, Remco de Bree, Andres Coca-Pelaz, Cesare Piazza, Carlos Chiesa-Estomba, Fernando Lopez, Nabil F. Saba, Alessandra Rinaldo, Alfio Ferlito
Summary: The management of cT3 laryngeal cancers remains controversial, and there is a lack of studies showing which treatment has better survival outcomes. This study compared total laryngectomy, concurrent chemoradiation, and radiation therapy alone in T3 laryngeal cancers and found that TL and CRT had similar overall survival outcomes, which were better than RT alone.
Article
Surgery
Sander Ubels, Moniek H. P. Verstegen, Bastiaan R. Klarenbeek, Stefan Bouwense, Mark I. van Berge Henegouwen, Freek Daams, Marc J. van Det, Ewen A. Griffiths, Jan Willem Haveman, Joos Heisterkamp, Grard Nieuwenhuijzen, Fatih Polat, Jeroen Schouten, Peter D. Siersema, Pritam Singh, Bas Wijnhoven, Gerjon Hannink, Frans van Workum, Camiel Rosman
Summary: This retrospective cohort study aimed to assess the effectiveness of different treatment strategies for anastomotic leak after oesophagectomy. The study found that less invasive primary treatment resulted in fewer complications. Therefore, less invasive primary treatment may lead to better clinical outcomes, but further studies are needed to confirm these findings.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Orthopedics
Stan R. W. Wijn, Gerjon Hannink, Jonas B. Thorlund, Raine Sihvonen, Martin Englund, Maroeska M. Rovers
Summary: This study compared patients undergoing arthroscopic partial meniscectomy (APM) in randomized controlled trials (RCTs) and prospective cohort studies. Although there were minimal differences in knee pain, overall knee function, and quality of life between the two groups, differences in age and disease severity were observed.
