Article
Oncology
Rebecca L. Siegel, Nikita Sandeep Wagle, Andrea Cercek, Robert A. Smith, Ahmedin Jemal
Summary: Colorectal cancer is the second leading cause of cancer death in the United States. The incidence of CRC has slowed down, but it is shifting to a younger age, advanced stage, and left colon/rectum. Mortality from CRC has declined overall, but increased in individuals younger than 50 years and Native Americans younger than 65 years. Uncovering the reasons for rising incidence and improving access to screening and treatment are crucial in combating CRC.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Oncology
Mimi Ton, Nathaniel F. Watson, Arthur Sillah, Rachel C. Malen, Julia D. Labadie, Adriana M. Reedy, Stacey A. Cohen, Andrea N. Burnett-Hartman, Polly A. Newcomb, Amanda I. Phipps
Summary: The study found that colorectal cancer patients, especially those with rectal cancer, are more likely to experience sleep issues, such as changes in sleep patterns after diagnosis. This suggests that sleep-focused survivorship care may need to be adapted based on colorectal cancer site to provide appropriate support for patients.
Article
Gastroenterology & Hepatology
Joshua Demb, Lin Liu, Caitlin C. Murphy, Chyke A. Doubeni, Maria Elena Martinez, Samir Gupta
Summary: The incidence of young-onset colorectal cancer (YCRC) is increasing, and there may be an association between iron-deficiency anaemia (IDA), haematochezia, and YCRC in US Veterans aged 18-49. By comparing individuals with IDA or haematochezia to those without, the cumulative incidence and risk of YCRC can be assessed.
Article
Oncology
Linnea Uebel, Indy Kromodikoro, Nils Nyhlin, Michiel van Nieuwenhoven
Summary: This study evaluated the performance of the Swedish Standardized Course of Care for colorectal cancer (SCC-CRC) in diagnosing colorectal cancer. The results showed that the CRC yield from SCC-CRC was slightly higher compared to other European fast tracks. Some entry criteria did not provide any benefit in assessing CRC risk, while the fecal immunochemical test (FIT) showed high diagnostic efficacy.
Article
Gastroenterology & Hepatology
Caitlin C. Murphy, Piera M. Cirillo, Nickilou Y. Krigbaum, Amit G. Singal, MinJae Lee, Timothy Zaki, Ezra Burstein, Barbara A. Cohn
Summary: The study found that maternal obesity may increase the risk of CRC in offspring, especially those under the age of 50. Discordant growth in early and late pregnancy weight gain rates may also increase the risk. Higher birth weight is also associated with a higher risk of CRC.
Article
Medicine, General & Internal
Yingshuang Zhu, Yeting Hu, Xiangxing Kong, Qian Xiao, Zhizhong Pan, Zhaoxu Zheng, Ye Wei, Wang Ziqiang, Da Wang, Jiaqi Chen, Kun Chen, Shu Zheng, Meilin Wang, Xifeng Wu, Kefeng Ding
Summary: The National Colorectal Cancer Cohort (NCRCC) study aims to assess risk factors and biomarkers related to colorectal cancer, using data from screening and patient cohorts. The study collects demographic, lifestyle, clinical information, survivorship endpoints, and various biospecimens, with the goal of conducting studies to optimize evidence-based guidelines for colorectal cancer.
Article
Medicine, General & Internal
Kevin B. Laupland, Felicity Edwards, Luis Furuya-Kanamori, David L. Paterson, Patrick N. A. Harris
Summary: This study investigated the risk of colorectal cancer-associated bloodstream infections in Queensland, Australia. The researchers found that individuals with bloodstream infections had a 16-fold increased risk of being diagnosed with colorectal cancer. The organisms associated with the highest risk of colorectal cancer included Clostridium species and Bacteroides species.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Oncology
Linda A. Liang, Ying-Ju Tseng, Luana F. Tanaka, Stefanie J. Klug
Summary: Increasing survival rates for colorectal cancer (CRC) means more survivors are developing second primary cancer (SPC), particularly in younger populations. This study estimated the incidence and risk factors of SPC in CRC survivors. The study found that CRC survivors had a higher risk of developing other cancers compared to the general population, with increased risks in the digestive and urinary systems, as well as reproductive organs. Younger individuals (<50 years) had a significantly higher incidence of SPC, with primary tumor characteristics such as right-sided cancer and smaller tumor size associated with increased risk. Treatment and risk of SPC differed between colon cancer and rectal cancer. The findings suggest the need for targeted surveillance for CRC survivors.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Hidetaka Itoh, Hidehiro Kaneko, Akira Okada, Yuichiro Yano, Kojiro Morita, Hikari Seki, Hiroyuki Kiriyama, Tatsuya Kamon, Katsuhito Fujiu, Satoshi Matsuoka, Sunao Nakamura, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Akira Nishiyama, Koichi Node, Hideo Yasunaga, Issei Komuro
Summary: The study found that as fasting plasma glucose levels increased, the risk of colorectal cancer also increased. Monitoring FPG levels could help identify individuals at high risk for future colorectal cancer.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Tin Tin Su, Felix Oluyemi Adekunjo, Desiree Schliemann, Christopher R. Cardwell, Mila Nu Nu Htay, Maznah Dahlui, Siew Yim Loh, Victoria L. Champion, Michael Donnelly
Summary: This study aimed to culturally adapt and validate the CHBMS-CRC-M scale to assess perceptions and beliefs about CRC screening in Malaysia. Results demonstrated that the scale was culturally acceptable and achieved good face validity among the three main ethnic groups in Malaysia.
Article
Multidisciplinary Sciences
Mesnad Alyabsi, Majed Ramadan, Mohammed Algarni, Kanan Alshammari, Abdul Rahman Jazieh
Summary: A study in Saudi Arabia found that unmarried CRC patients were more likely to be diagnosed at a late stage and had a higher risk of death due to CRC compared to married patients. Future interventions should focus on early cancer screening and survivorship programs for the unmarried population to improve cancer outcomes.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ranmali Ranasinghe, Michael Mathai, Anthony Zulli
Summary: Colorectal cancer is a malignancy in the GI tract with limited treatment options despite extensive research. This article summarizes the features of colorectal cancer and presents strategies for improving its management.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Gastroenterology & Hepatology
Hanseul Kim, Marla Lipsyc-Sharf, Xiaoyu Zong, Xiaoyan Wang, Jinhee Hur, Mingyang Song, Molin Wang, Stephanie A. Smith-Warner, Charles Fuchs, Shuji Ogino, Kana Wu, Andrew T. Chan, Yin Cao, Kimmie Ng, Edward L. Giovannucci
Summary: The results of the study show that higher total vitamin D intake is associated with decreased risks of early-onset colorectal cancer (CRC) and precursors in women. The inverse association was more evident for dietary sources of vitamin D compared to supplemental vitamin D intake.
Article
Gastroenterology & Hepatology
Nikos Papadimitriou, Emmanouil Bouras, Piet A. Van den Brandt, David C. Muller, Areti Papadopoulou, Alicia K. Heath, Elena Critselis, Marc J. Gunter, Paolo Vineis, Pietro Ferrari, Elisabete Weiderpass, Heiner Boeing, Nadia Bastide, Melissa A. Merritt, David S. Lopez, Manuela M. Bergmann, Aurora Perez-Cornago, Matthias Schulze, Guri Skeie, Bernard Srour, Anne Kirstine Eriksen, Stina Boden, Ingegerd Johansson, Therese Haugdahl Nost, Marco Lukic, Fulvio Ricceri, Ulrika Ericson, Jose Maria Huerta, Christina C. Dahm, Claudia Agnoli, Pilar Exezarreta Amiano, Anne Tjonneland, Aurelio Barricarte Gurrea, Bas Bueno-De-Mesquita, Eva Ardanaz, Jonna Berntsson, Maria-Jose Sanchez, Rosario Tumino, Salvatore Panico, Verena Katzke, Paula Jakszyn, Giovanna Masala, Jeroen W. G. Derksen, J. Ramon Quiros, Gianluca Severi, Amanda J. Cross, Ellio Riboli, Ioanna Tzoulaki, Konstantinos K. Tsilidis
Summary: This study examined the association between dietary exposures and colorectal cancer (CRC) risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Netherlands Cohort Study (NLCS). The results showed a positive association between the intake of alcohol, liquor/spirits, soft drinks, and pork and CRC risk, while the intake of milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein were inversely associated with CRC risk.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kota Arima, Rong Zhong, Tomotaka Ugai, Melissa Zhao, Koichiro Haruki, Naohiko Akimoto, Mai Chan Lau, Kazuo Okadome, Raaj S. Mehta, Juha P. Vayrynen, Junko Kishikawa, Tyler S. Twombly, Shanshan Shi, Kenji Fujiyoshi, Keisuke Kosumi, Yoko Ogata, Hideo Baba, Fenglei Wang, Kana Wu, Mingyang Song, Xuehong Zhang, Charles S. Fuchs, Cynthia L. Sears, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Wendy S. Garrett, Curtis Huttenhower, Andrew T. Chan, Jonathan A. Nowak, Marios Giannakis, Shuji Ogino
Summary: This study found that a Western-style diet is associated with a higher incidence of colorectal cancer containing abundant pks(+) E coli, providing further support for a potential link between diet, the intestinal microbiota, and colorectal carcinogenesis.
Article
Oncology
Daniela Mariosa, Karl Smith-Byrne, Tom G. Richardson, Pietro Ferrari, Marc J. Gunter, Nikos Papadimitriou, Neil Murphy, Sofia Christakoudi, Konstantinos K. Tsilidis, Elio Riboli, David Muller, Mark P. Purdue, Stephen J. Chanock, Rayjean J. Hung, Christopher Amos, Tracy A. O'Mara, Pilar Amiano, Fabrizio Pasanisi, Miguel Rodriguez-Barranco, Vittorio Krogh, Anne Tjonneland, Jytte Halkjaer, Aurora Perez-Cornago, Maria-Dolores Chirlaque, Guri Skeie, Charlotta Rylander, Kristin Benjaminsen Borch, Dagfinn Aune, Alicia K. Heath, Heather A. Ward, Matthias Schulze, Catalina Bonet, Elisabete Weiderpass, George Davey Smith, Paul Brennan, Mattias Johansson
Summary: It is unclear if body weight in early life affects cancer risk independently of adult body weight. Both Mendelian randomization and longitudinal analyses suggest that larger early life body size is associated with higher risk of endometrial and kidney cancer, but these associations are attenuated after accounting for adult body size. Early life body mass index does not consistently associate with other investigated cancers.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Niki Dimou, Wemimo Omiyale, Carine Biessy, Vivian Viallon, Rudolf Kaaks, Tracy A. O'Mara, Elom K. Aglago, Eva Ardanaz, Manuela M. Bergmann, Nicola P. Bondonno, Tonje Braaten, Sandra M. Colorado-Yohar, Marta Crous-Bou, Christina C. Dahm, Renee T. Fortner, Inger T. Gram, Sophia Harlid, Alicia K. Heath, Annika Idahl, Marina Kvaskoff, Therese H. Nost, Kim Overvad, Domenico Palli, Aurora Perez-Cornago, Carlotta Sacerdote, Maria-Jose Sanchez, Matthias B. Schulze, Gianluca Severi, Vittorio Simeon, Giovanna Tagliabue, Anne Tjonneland, Therese Truong, Rosario Tumino, Mattias Johansson, Elisabete Weiderpass, Neil Murphy, Marc J. Gunter, Ben Lacey, Naomi E. Allen, Laure Dossus
Summary: This study investigates the association between smoking and endometrial cancer risk through observational and Mendelian randomization analyses. The observational analysis finds an inverse association between smoking and endometrial cancer risk, but this is not supported by the Mendelian randomization analysis. Further research is needed to understand the potential confounders and mechanisms underlying the observed associations between smoking and endometrial cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Medicine, General & Internal
Matilde Bandeira, Federica Di Cianni, Diana Marinello, Laurent Arnaud, Sara Cannizzo, Claudio Carta, Alain Cornet, Sara M. Barril, Inita Bulina, Alessandro Ferraris, Joao Fonseca, Andrea Gaglioti, Marteen Limper, Valentina Lorenzoni, Judith Majnik, Marco Matucci-Cerinic, Ilaria Palla, Simona Rednic, Matthias Schneider, Vanessa Smith, Alberto Sulli, Klaus Sondergaard, Simone Ticciati, Angela Tincani, Giuseppe Turchetti, Rosaria Talarico, Maurizio Cutolo, Marta Mosca, Domenica Taruscio
Summary: This study provides an overview of existing registries for rCTDs through an online survey and database search, aiming to establish a unified data collection approach in Europe.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
G. Andreozzi, V. Lorenzoni, I. Bargellini, R. Cioni, G. Turchetti
Summary: This study aimed to evaluate the cost-utility of drug-eluting microspheres (DEM) transarterial chemoembolization (TACE) compared to conventional (C)-TACE in patients with hepatocellular carcinoma from the perspective of a Local Healthcare Authority in Italy. The results showed that although DEM-TACE had higher costs compared to C-TACE, it had a positive impact on quality-adjusted life years (QALY). Probabilistic sensitivity analysis indicated that using median costs, DEM-TACE was always cost-effective, while using mean costs, it was preferable only 24.7% of the time.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Surgery
Luca Morelli, Niccolo Furbetta, Matteo Palmeri, Simone Guadagni, Gregorio Di Franco, Desiree Gianardi, Rosa Cervelli, Valentina Lorenzoni, Annalisa Comandatore, Cristina Carpenito, Giulio Di Candio, Alfred Cuschieri
Summary: This study analyzed the outcomes of the first 50 consecutive robotic pancreatoduodenectomy (R-PD) performed by an experienced surgeon using the da Vinci Xi system. The results showed that performing the surgery in a high-volume center with prior experience in pancreatic surgery and robotic assisted surgery significantly reduces the learning curve and achieves a low risk of conversion to open surgery in the first 50 operations.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Public, Environmental & Occupational Health
Deependra Singh, Jerome Vignat, Valentina Lorenzoni, Marzieh Eslahi, Ophira Ginsburg, Beatrice Lauby-Secretan, Marc Arbyn, Partha Basu, Freddie Bray, Salvatore Vaccarella
Summary: Tracking progress and providing evidence are essential for countries to achieve the WHO's goal of eliminating cervical cancer. This study assessed global inequalities in cervical cancer incidence and mortality based on the GLOBOCAN 2020 estimates, considering geographical and socioeconomic factors.
LANCET GLOBAL HEALTH
(2023)
Article
Oncology
Cody Z. Watling, Rebecca K. Kelly, Neil Murphy, Marc Gunter, Carmen Piernas, Kathryn E. Bradbury, Julie A. Schmidt, Timothy J. Key, Aurora Perez-Cornago
Summary: Higher intakes of whole grains and fiber are associated with lower risk of colorectal cancer, especially in individuals with high production of short-chain fatty acids (SCFA). The study found that consuming more whole grain starch and non-free sugar was inversely associated with colorectal cancer risk. However, this protective effect of whole grain intake may vary depending on an individual's genetic predisposition for SCFA production.
Article
Oncology
Danny R. R. Youlden, Eva Steliarova-Foucher, Andrea Gini, Neimar De Paula Silva, Joanne F. F. Aitken
Summary: Survivors of childhood cancer face an increased risk of long-term health problems due to treatment side effects. Using data from the Australian Childhood Cancer Registry (ACCR), a total of 17,468 prevalent cases of childhood cancer survivors aged 0-14 at diagnosis between 1983 and 2018 were identified. The number of 5-year prevalent cases also showed an 80% increase, from 1979 in 1988 to 3566 in 2018. Both short- and long-term prevalence estimates are crucial for monitoring childhood cancer survivorship and planning for their specific needs.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Public, Environmental & Occupational Health
Ganfeng Luo, Yanting Zhang, Jaione Etxeberria, Melina Arnold, Xiuyu Cai, Yuantao Hao, Huachun Zou
Summary: The future incidence of lung cancer is predicted to decrease among males and increase among females in most countries. The peak of female lung cancer incidence is expected to occur after the 2020s in European, Eastern Asian, and Oceanian countries. The highest ASRs are projected to occur among males in Belarus and among females in Denmark in 2035.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Oncology
Niki Dimou, Andre E. Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K. Aglago, Emmanouil Bouras, Peter T. Campbell, Graham Casey, Steven Gallinger, Stephen B. Gruber, Mark A. Jenkins, Yi Lin, Victor Moreno, Edward Ruiz-Narvaez, Mariana C. Stern, Yu Tian, Kostas K. Tsilidis, Volker Arndt, Elizabeth L. Barry, James W. Baurley, Sonja I. Berndt, Stephane Bezieau, Stephanie A. Bien, D. Timothy Bishop, Hermann Brenner, Arif Budiarto, Robert Carreras-Torres, Tjeng Wawan Cenggoro, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Xuechen Chen, David V. Conti, Christopher H. Dampier, Matthew Devall, David A. Drew, Jane C. Figueiredo, Graham G. Giles, Andrea Gsur, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Kristina Jordahl, Eric Kawaguchi, Temitope O. Keku, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John Morrison, Polly A. Newcomb, Christina C. Newton, Mireia Obon-Santacana, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Peter C. Scacheri, Robert E. Schoen, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Cornelia M. Ulrich, Caroline Y. Um, Franzel J. B. van Duijnhoven, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Emily White, Alicja Wolk, Michael O. Woods, Conghui Qu, Anshul Kundaje, Li Hsu, W. James Gauderman, Marc J. Gunter, Ulrike Peters
Summary: Diabetes is a risk factor for colorectal cancer, but the mechanisms and genetic variants affecting this relationship are still unclear. Through genome-wide gene-environment interaction analysis, it was found that variations in insulin signaling gene (SLC30A8) and immune function gene (LRCH1) may modify the association between diabetes and colorectal cancer risk.
BRITISH JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Andrea Gini, Murielle Colombet, Neimar de Paula Silva, Otto Visser, Danny Youlden, Isabelle Soerjomataram, Charles A. Stiller, Eva Steliarova-Foucher
Summary: Estimating the number of childhood cancer survivors is crucial for cancer control, and a new method using a Markov model and aggregated data was proposed. The study found that the POCCS model provided consistent estimates compared to traditional methods, offering relevant information for planning follow-up care for childhood cancer survivors.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)